1.A case of Waldenström's macroglobulinemia treated using clarithromycin and prednisolone.
Masashi OHE ; Satoshi HASHINO ; Haruki SHIDA ; Tetsuya HORITA ; Mitsuru SUGIURA
Translational and Clinical Pharmacology 2017;25(3):134-137
We report a case of Waldenström's macroglobulinemia (WM) treated using clarithromycin (CAM) and prednisolone (PSL). An 84-year-old woman was admitted to our hospital for bleeding after a tooth extraction and hematuria. Computed tomography showed multiple ill-defined nodules in the omentum (omental cake). Although the cause of the omental cake remained unclear, the patient was diagnosed with WM, based on the detection of M-protein of immunoglobulin (Ig) M in serum and lymphoplasmacytes in bone marrow. The bleeding tendency in the patient may have been due to acquired hemophilia and/or hyper IgM-induced platelet dysfunction. The patient was treated using CAM (800 mg/day) and PSL (10 mg/day). As a result, IgM levels gradually decreased. Because the omental cake contracted along with improvement in IgM, it was thought to be lymphoplasmacytic lymphoma-like lymphoma. This case shows that treatment using CAM and PSL may be effective in some cases of WM.
Aged, 80 and over
;
Blood Platelets
;
Bone Marrow
;
Clarithromycin*
;
Female
;
Hematuria
;
Hemophilia A
;
Hemorrhage
;
Humans
;
Immunoglobulin M
;
Immunoglobulins
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Lymphoma
;
Omentum
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Prednisolone*
;
Tooth Extraction
;
Waldenstrom Macroglobulinemia*