No abstract available.
Misoprostol*

Labour induced effect of misoprostol in comparing with oxytoxin on the ending 3rd trimestre of pregnancy was studied in 180 subjects at the Central Hospital of Gynecology and Obstetrics from January 1997 to January 2003. In 89.89% of misoprostol applicants and 67.78% of oxytoxine applicant success were reached. Labour induced meantime of misoprostol applicants 6.25  2.07 hours, oxitoxine 4.31  2.29 hours. Vaginal tract delivery in 88.3% of misoprostol applicant group and 70% of oxytoxine. Caesarian section 27.78% in misoprostol group, lower than oxytoxine group 44.44%.
Misoprostol ; Oxytocin ; Pharmaceutical Preparations

A randomised controlled clinical trial was performed on 180 pregnant women with indications for labour induction who were divided into 2 groups. Groups 1: each pregnant woman received 50 μg intravaginal misoprostol every 4h (total 250 μg). Group 2: intravenous oxyticin to induce the labour. The successful rate of misoprotol group was 89,89%, higher than oxytocin group- 70%. The interval from induction to vaginal delivery was longer in misoprostol group (8,47± 2,85h verus 6,45± 2,64h)
Labor, Induced ; misoprostol ; Oxytocin ;

90 cases of pregnancy termination by vaccum at the 6th –12th week of gestation, using misoprostol vaginal insertion with cervix prepared 3 hours before this operation were performed at the Central Hospital of Gynecology and Obstetrics from December 2003 to February 2004. The subjects had received intravaginal 400mg Misoprostol 3h befor the vacuum aspiration of the fetus. Results showed the success rate of 96.67%, the mean dilatation of cervix reached 8.1  0.92mm.
Pregnancy Trimester, First ; Misoprostol ; Pregnancy

From Dec. 2003 to Feb 2004, 90 women of 6-12 week pregnancy received 100 μg intra vaginal misoprostol 3 hours before intervention at central Hospital of Ggn. and Obst. 96,67% had got success, with the mean cervical dilatation of 8,1± 0,92mm. Side effect manifested in 2,2% of patients
Misoprostol ; pregnancy ; Labor Stage, First

The study was carried out at Hung Vuong Hospital in 1998 to compare vaginal misoprostol with extra-amniotic balloon to induce abortion in second trimester. Patients were received either 800mcg misoprostol vaginally (n=87) or 500ml of 0.9% NaCl solution inserted into extra-amniotic cavity (n= 93) for induced abortion. Vaginal misoprostol was repeated 24-hourly for maximum of three times. The abortion rates were 98.9% and 96.8% for misoprostol and balloon group, respectively. A second attempt was need in approximate one third of patients in misoprostol group and 10% in balloon group. Side effects of misoprostol were mild and transient. Vaginal misoprostol is as effective as balloon for induced abortion in second trimester. Misoprostol is cheap and easily stored and used. Vaginal misoprostol could be considered as an alternative to balloon for induced abortion
Abortion, Therapeutic ; Misoprostol ; Abortion, Induced

A retrospective study of 200 Kovacs has been applied in 2nd trimester abortion in 1997 and other 200 by MSP in 1998. -MSP could be efficacy in 2nd trimester abortion as Kovacs.-In first 48h, the natural abortion by MSP and Kovacs is the same.-The propotion of MSP abortion is higher than Kovacs, hospitalized stay length of MSP is shorter than Kovacs.-No infection in MSP trials
Misoprostol ; Pregnancy Trimester, Second ; Pregnancy ; Abortion, Induced

OBJECTIVE: The aim of this study was to compare the efficacy and safety of oral prostaglandin (PG) E1, misoprostol, and vaginal PGE2, dinoprostone pessary, in the induction of labor at term. METHODS: From March 2004 to March 2006, we retrospectively analyzed 175 women who underwent labor induction at term with an unfavorable cervix (the Bishop score=4). Women in the misoprostol group (n=72) received 100 microgram oral misoprostol and the second dose could be repeated every 6 hours if the Bishop score remained at 4 or less. Women in the dinoprostone group (n=103) received 10 mg vaginal dinoprostone pessary. Intravenous oxytocin, if necessary, was administrated 6 hours after the last dose of oral misoprostol or removal of the dinoprostone pessary. RESULTS: Mode of delivery and indications for cesarean delivery were similar in the two groups. The interval from PG administration to active phase of labor (median [range], 9.6 [3.0~37.2] hr vs. 12.0 [1.8~41.7] hr, p<0.05) and vaginal delivery (median [range], 12.7 [3.2~38.4] hr vs. 15.5 [3.3~ 37.1] hr, p<0.05) were shorter in the misoprostol group than the dinoprostone group. However, delivery within 12 hours and within 24 hours after PG administration was similar in the two groups. Uterine hyperstimulation syndrome occurred in 5 (6.9%) women in the misoprostol group and in none in the dinoprostone group (p<0.05). The neonatal outcome was not different between the two groups. CONCLUSION: Overall, oral misoprostol is as effective as vaginal dinoprostone pessary for induction of labor at term, but it is associated with shorter labor induction time and higher risk of uterine hyperstimulation syndrome.
Cervix Uteri ; Dinoprostone* ; Female ; Humans ; Misoprostol* ; Oxytocin ; Pessaries* ; Retrospective Studies

OBJECTIVE: The purpose of this study was to compare the efficacy of intravaginal misoprostol and that of intravenous sulprostone for termination of second-trimester pregnancy. METHODS: Fouty-six patients were randomly assigned to misoprostol and sulprostone group, and the misoprostol group was further divided into two groups according to gestational age. In the misoprostol group, the patients at or before 20 weeks of gestation received 400 microgram of intravaginal misoprostol every 4 hours until labor pain was established, 200 microgram every 6 hours after 20 weeks of gestation. In the sulprostone group, intravenous sulprostone was infused at the speed of 100 microgram/hr regardless of gestational age. RESULTS: At or before 20 weeks of gestation, the mean time from induction to completion of termination was shorter, and the success rate within 24 hours was higher in the misoprostol group than in the sulprostone group (9.0 vs. 20.2 hours; 86% vs 50%). After 20 weeks, the mean induction time was longer at misoprostol group than sulprostol group but, there was no significant difference in success rate within 24 hours (14.7 vs. 7.1 hours; 83% vs. 86%). There was no significant difference in the prevalence of complication between two groups. CONCLUSION: Misoprostol is superior to sulprostone for termination of pregnancy at or before 20 weeks of gestation, but both have almost equal effectiveness after 20 weeks of gestation. Considering less cost and complication, the efficacy of misoprostol should be further investigated for termination of second-trimester pregnancy.
Female ; Gestational Age ; Humans ; Labor Pain ; Misoprostol* ; Pregnancy* ; Prevalence

OBJECTIVE: To evaluate the effectiveness of single preoperative dose of misoprostol to reduce intraoperative hemorrhage during laparoscopic myomectomy. METHODS: We reviewed retrospectively the medical records of 148 patients who underwent laparoscopic myomectomy in Gangnam CHA Medical Center between January 2007 and December 2009 by single surgeon. Among them, 46 patients used preoperative transrectal misoprostol. One hundred two patients underwent laparoscopic myomectomy in conventional method without any preoperative agents. RESULTS: The two groups were similar in baseline characteristics. There was no significant difference in mean blood loss (misoprostol group: 203.3+/-181.8 mL vs. no agent group: 207.7+/-144.5 mL), operation time (misoprostol group: 113.3+/-28.2 min vs. no agent group: 113.4+/-31.5 min), and hemoglobin change (misoprostol group: 2.0+/-1.0 g/dL vs. no agent group: 1.9+/-1.0 g/dL). Two patients needed transfusion in misoprostol group whereas none in control group, but there was no statistical significance. CONCLUSION: A single preoperative dose of transrectal misoprostol cannot reduce bleeding during laparoscopic myomectomy.
Hemoglobins ; Hemorrhage ; Humans ; Medical Records ; Misoprostol ; Retrospective Studies