A 62-year-old man with a flat early esophageal cancer was referred for endoscopic treatment. White light imaging revealed a pale red lesion, whereas linked color imaging (LCI) and blue laser imaging (BLI) yielded purple and brown images, respectively. Iodine staining demonstrated a large unstained area with a homogenous but very weak pink-color sign. This area appeared more clearly as purple and green on LCI and BLI, respectively; however, a different colored portion was observed at the 4 o'clock position inside the iodine-unstained area. Histopathology findings of the resected specimen revealed squamous intraepithelial neoplasia at the 4 o'clock position and an esophageal squamous cell carcinoma in the remaining iodine-unstained area. LCI and BLI combined with iodine staining produce characteristic images that overcomes the pink-color sign, reflecting the histological features of a flat esophageal neoplasm. This new method is useful for detailed evaluation of early flat squamous cell neoplasms.
Carcinoma, Squamous Cell ; Epithelial Cells ; Esophageal Neoplasms ; Humans ; Iodine ; Methods ; Middle Aged ; Neoplasms, Squamous Cell

Objective: This study aimed to elucidate the sense of self-usefulness among patients with advanced cancer receiving chemotherapy in ambulatory care. Methods: Semi-structured interviews were conducted with 20 patients regarding their desire to contribute to others, their everyday lives, and changes in their roles. The text was subjected to qualitative content analysis. Result: Five themes as the sense of self-usefulness finally emerged: “contribution to others,” “approval from oneself and others,” “value given to existence,” “maintenance of independence,” and “integration of life.” Conclusion: The findings suggest that the sense of self-usefulness among patients with advanced cancer who are undergoing chemotherapy is complex. It involves concerns about their independence being threatened and their awareness of the limited time remaining, alongside the looming specter of death amid the worsening and progression of their disease.