1.Development of the multi-target-directed acetylcholinesterase inhibitors based on tacrine
Minzhong YE ; Zhiyi CHENG ; Rongbiao PI
Chinese Pharmacological Bulletin 2003;0(12):-
Acetylcholinesterase is an important target for anti-Alzheimer's disease now.Much attention has been paid to the development of tacrine dimeric or hybrid compounds.The design strategy is transforming merely interacting with the two binding sites of acetylcholinesterase to get more activity and selectivity into the multi-target-directed function for the treatment of Alzheimer's disease. Herein,the tacrine dimeric or hybrid compounds development and the prospect for the treatment of AD have been reviewed.
2.Comparison between different calculation methods of limbs joints function.
Qing-Mu CHEN ; Wei LI ; Ye-Qiong WANG
Journal of Forensic Medicine 2011;27(4):256-259
OBJECTIVE:
To analyze and compare different methods for assessment of the limbs joints function and to discuss the rationality of the methods.
METHODS:
Eight hundred and six cases were collected from the Fujian Minzhong Forensic Appraisal Center from 2007 to 2010. These cases included injuries of large limbs joints with or without peripheral nerve injury. The loss of joint function was calculated according to the simple joint mobility method or the table method introduced in the book "Forensic Clinical Judicial Authentication Practice". The results of disability evaluation with different methods were analyzed and compared between different joints and injury patterns.
RESULTS:
In 642 cases of simple joint injuries without peripheral nerve injury, the results of disability evaluation based on simple joint mobility were the same as that based on the table. In 118 cases of joint injuries with peripheral nerve injury, all of them could be classified as disability, 33 cases (28.00%) had higher degree based on the table method than based on the simple joint mobility method. While 21 cases (17.80%) did not be evaluated as disabled based on the simple joint mobility method.
CONCLUSION
The evaluation for loss of limb function would be easier, more scientific and reasonable by the direct table method than the simple joint mobility method.
Accidents, Traffic
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Adult
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Arm Injuries/physiopathology*
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Disability Evaluation
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Extremities
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Female
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Forensic Medicine/methods*
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Humans
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Joints/physiopathology*
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Leg Injuries/physiopathology*
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Male
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Peripheral Nerve Injuries/physiopathology*
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Range of Motion, Articular/physiology*
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Trauma Severity Indices