1.Osteochondritis Dissecans of the Capitellum Humeri: Analysis of C. T. Findings
Kwon Ick HA ; Sung Ho HAHN ; Minyoung CHUNG ; Bo Kyu YANG ; Chang Woo KIM
The Journal of the Korean Orthopaedic Association 1994;29(2):526-533
We have compared the computed tomographic(C. T.) findings with those of conventional roentgenogram(simple AP and lateral radiograms) in 18 cases of osteochondritis dissecans of the capitellum humeri available for review. Among the 18 cases, 2 cases of them had a lesion of osteochondritis dissecans on C. T. which, however, had not been found on conventional rentgenograms. Fro the 5 cases, which had not clearly found on conventional rentgenograms, 2 loose body on conventional view, 3 cases had different numbers and locations of loose body on C. T. films. On the bases of our findings, we recommend that C. T. is necessary in early detection and the determination of anatomical location and status of osteochondritis dissecans of capitellum.
Osteochondritis Dissecans
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Osteochondritis
2.Untact Visit Service Development Based on an Application Reflecting the Circumstances during COVID-19: Focusing on Utilization in the Pediatric Intensive Care Units
Dahae WOO ; Hanui YU ; Hyo Jin KIM ; Minyoung CHOI ; Dong Hee KIM
Journal of Korean Academy of Nursing 2021;51(5):573-584
Purpose:
This study aimed to develop an untact visit service based on an application that can be utilized in the pediatric intensive care unit (PICU) during COVID-19.
Methods:
This study adopted the double diamond process of service design comprising the discovery, defining, and development stages.
Results:
We developed an untact visit service based on an application that considered the child’s status, schedule, photo, and video messages, and so on. Moreover, we derived a service flow regarding the required roles and the type of flow shown between each stakeholder.
Conclusion
Considering the ongoing pandemic, the untact visit service is designed to increase rapport and participation of parents, share the child’s information in real-time, and provide one-stop service without increasing healthcare providers’ work. It will be a useful visit service that can be applied and evaluated in various hospital settings and the PICU.
3.Stress Coping Strategies and Quality of Life in Patients with Schizophrenia.
Mijeong LIM ; Minyoung SIM ; Sungun CHAE ; Won Hye LEE ; Joonho NA ; Daeho KIM
Journal of Korean Neuropsychiatric Association 2015;54(2):181-187
OBJECTIVES: The aims of this study were to investigate the pattern of stress coping strategies and the effects of stress coping strategies on quality of life in patients with schizophrenia. METHODS: Stress coping strategies and quality of life were examined using Ways of Coping Checklist and Schizophrenia Quality of Life Scale for 98 patients with schizophrenia. Stress coping strategies were composed of problem-focused coping, social support seeking, emotion-focused coping, and wishful thinking. Among these, problem-focused coping and social support seeking were active coping strategies while emotion-focused coping and wishful thinking were passive coping strategies. Positive and Negative Syndrome Scale (PANSS) and Beck's Depression Inventory (BDI) were also administered. RESULTS: Active coping scores were higher than passive coping scores in patients with schizophrenia. Quality of life was higher in the active coping group compared to the passive coping group. Active coping usage was a significant predictor of higher quality of life even after controlling for gender, age, PANSS, and BDI scores. CONCLUSION: Patients with schizophrenia used more active coping strategies than passive coping strategies, which showed significant association with higher quality of life. A treatment program to provide education on use of active coping strategies in a proper and flexible way might contribute to enhanced quality of life in patients with schizophrenia.
Adaptation, Psychological
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Checklist
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Depression
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Education
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Humans
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Quality of Life*
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Schizophrenia*
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Stress, Psychological
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Thinking
4.Functional Role of Parkin against Oxidative Stress in Neural Cells.
Minyoung HWANG ; Ja Myong LEE ; Younghwa KIM ; Dongho GEUM
Endocrinology and Metabolism 2014;29(1):62-69
BACKGROUND: Parkinson disease (PD) is caused by selective cell death of dopaminergic neurons in the substantia nigra. An early onset form of PD, autosomal recessive juvenile parkinsonism has been associated with a mutation in the parkin gene. The function of parkin is known to remove misfolding proteins and protect cell death. We aimed to investigate the role of parkin against oxidative stress in neuronal cells. METHODS: Parkin knockout embryonic stem cells (PKO ES cells) were differentiated into neurons by adherent monolayer culture method. Oxidative stress was induced by the treatment of 1-methyl-4-phenylpyridinium (MPP+) in neurons derived from wild type and PKO ES cells, and cell viability was examined by MTT assay. After exposure to MPP+, Tuj1-positive cell population was compared between PKO and wild type cells by fluorescence activated cell sorter (FACS) analysis. The activated caspase3 protein level was also measured by Western blot analysis, FACS and immunocytochemistry. RESULTS: There was no difference in the efficiency of neuronal differentiation between wild type and PKO ES cells. After exposure to MPP+, no significant differences were found in cell viability and Tuj1-positive cell population between the two groups determined by MTT assay and FACS analysis, respectively. The activated caspase3 protein levels examined by Western blot analysis, FACS and immunocytochemistry were not changed in PKO cells compared with those of wild type cells after MPP+ treatment. CONCLUSION: These results suggest that PKO neuronal cells including dopaminergic neurons are not sensitive to caspase3-dependent cell death pathway during the response against MPP+-induced oxidative stress.
1-Methyl-4-phenylpyridinium
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Blotting, Western
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Cell Death
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Cell Survival
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Dopaminergic Neurons
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Embryonic Stem Cells
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Fluorescence
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Immunohistochemistry
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Neurons
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Oxidative Stress*
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Parkinson Disease
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Parkinsonian Disorders
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Substantia Nigra
5.The Effect of Recombinant Human Growth Hormone Therapy in Patients with Completed Stroke: A Pilot Trial.
Junyoung SONG ; Kicheol PARK ; Hakil LEE ; Minyoung KIM
Annals of Rehabilitation Medicine 2012;36(4):447-457
OBJECTIVE: To evaluate the safety and potential efficacy of "recombinant human growth hormone (rhGH)" on the functional recovery of completed stroke patients. METHOD: Completed stroke patients were recruited. All participants were randomly assigned to the GH group (rhGH injection and rehabilitative therapy) or the control group (only rehabilitative therapy). Above all, they were closely monitored for safety. Further, for the efficacy measurement, Korean Modified Barthel Index (K-MBI), Manual Muscle strength Test (MMT), and Fugl-Meyer assessment (FMA) were assessed to determine the changes of functional recovery during 6-months of the study period. Along with it, diffusion tensor image was taken as the baseline, and a followed-up study to observe the changes in diffusion tensor tractography (DTT), during the period, and one patient in the GH group was also examined with functional MRI (fMRI). Index of fatigue on 5 point scale for the study period was also assessed. RESULTS: Twenty-two patients were enrolled, and 15 completed the study and were included in the analysis. No harmful adverse events were observed in the GH group. By comparison between the groups, the GH group showed more improvement in K-MBI than the control group (p<0.05). DTT showed less decrement of fibers in the GH group than in the control group, without statistical significance. fMRI showed an increment in the activated area. Patients in the GH group expressed no fatigue at all, during the study period (p=0.00). CONCLUSION: The administration of rhGH in long term resulted in the improvement in K-MBI, and subjectively less tiredness during the injection period.
Diffusion
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Fatigue
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Growth Hormone
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Human Growth Hormone
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Humans
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Insulin-Like Growth Factor I
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Magnetic Resonance Imaging
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Muscle Strength
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Stroke
6.Inter-rater Reliability of the K-GMFM-88 and the GMPM for Children with Cerebral Palsy.
Annals of Rehabilitation Medicine 2012;36(2):233-239
OBJECTIVE: To examine inter-rater reliability of the Korean version Gross Motor Function Measure (K-GMFM-88) and the Gross Motor Performance Measure (GMPM) based on the video clips. METHOD: We considered a sample of 39 children (28 boys and 11 girls; the mean age=3.50+/-1.23 years) with cerebral palsy (CP). Two pediatric physical therapists assessed the children based on video recordings. RESULTS: For the K-GMFM-88, the intraclass correlation coefficient (ICC3, 1) ranged from .978 to .995, and Spearman's correlation coefficient ranged from .916 to .997. For the GMPM, ICC3, 1 ranged from .863 to .929, and Spearman's correlation coefficient ranged from .812 to .885. With the gross motor function classification system classified according to the functional level (GMFCS I-II vs. III-V), the ICCs were .982 and .994 for the K-GMFM-88 total score and .815 and .913 for the GMPM total score. There were good or high correlations between the subscales of the two measures (r=.762-.884). CONCLUSION: The K-GMFM-88 and GMPM are reliable tools for assessing the motor function of children with CP. These two methods are highly correlated, which adds more reliability on them. Thus, it is advisable to use K-GMFM-88 and GMPM for children with CP to assess gross motor function.
Cerebral Palsy
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Child
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Humans
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Physical Therapists
7.Peripheral Blood Mononuclear Cells and Growth Factor Therapy for Cerebral Palsy.
Journal of Korean Medical Science 2018;33(21):e176-
No abstract available.
Cerebral Palsy*
8.Multivariate Analysis of Relationship between Childhood Trauma and Psychotic Symptoms in Patients with Schizophrenia.
Sungun CHAE ; Minyoung SIM ; Mijeong LIM ; Joonho NA ; Daeho KIM
Psychiatry Investigation 2015;12(3):397-401
The aim of this study was to examine the relationship between childhood trauma and psychotic symptoms in schizophrenic patients after controlling for the possible confounding factors, such as depression and dissociative symptoms. Ninety-eight schizophrenic inpatients participated. Childhood trauma was examined using the Childhood Trauma Questionnaires (CTQ), which consists of physical abuse (PA), sexual abuse (SA), emotional abuse (EA), physical neglect (PN), and emotional neglect (EN). Positive and Negative Syndrome Scale (PANSS), Dissociative Experience Scale (DES), and Beck's Depression Inventory (BDI) were also administered. Data were analyzed by partial correlation and general linear model. The total score of CTQ was positively correlated with positive, general, and total scores of PANSS. All five types of childhood trauma were associated with dissociative symptoms. EA and EN were positively correlated with depressive symptoms. Only SA significantly predicted positive symptoms of schizophrenia after controlling for age, sex, BDI, and DES scores, with a dose-response relationship between SA and positive symptoms.
Depression
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Humans
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Inpatients
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Linear Models
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Multivariate Analysis*
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Surveys and Questionnaires
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Schizophrenia*
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Sex Offenses
9.Mathematical Modeling of COVID-19 Transmission and Intervention in South Korea: A Review of Literature
Hyojung LEE ; Sol KIM ; Minyoung JEONG ; Eunseo CHOI ; Hyeonjeong AHN ; Jeehyun LEE
Yonsei Medical Journal 2023;64(1):1-10
South Korea implemented interventions to curb the spread of the novel coronavirus disease 2019 (COVID-19) pandemic with discovery of the first case in early 2020. Mathematical modeling designed to reflect the dynamics of disease transmission has been shown to be an important tool for responding to COVID-19. This study aimed to review publications on the structure, method, and role of mathematical models focusing on COVID-19 transmission dynamics in Korea. In total, 42 papers published between August 7, 2020 and August 21, 2022 were studied and reviewed. This study highlights the construction and utilization of mathematical models to help craft strategies for predicting the course of an epidemic and evaluating the effectiveness of control strategies. Despite the limitations caused by a lack of available epidemiological and surveillance data, modeling studies could contribute to providing scientific evidence for policymaking by simulating various scenarios.
10.Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead
Hwayoung LEE ; Minyoung LEE ; Hyung Ki KIM ; Young Ock KIM ; Jun Tack KWON ; Hak Jae KIM
The Korean Journal of Physiology and Pharmacology 2019;23(6):467-474
Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead acetate (0.2%) in drinking water during pregnancy and lactation causes behavioral impairment and affects the expression of proteins associated with neurodevelopment. Lead exposure altered several parameters in rat offspring compared with those unexposed in open-field, social interaction, and pre-pulse inhibition tests. These parameters were restored to normal levels after clozapine treatment. Western blot and immunohistochemical analyses of the hippocampus revealed that several neurodevelopmental proteins were downregulated in lead-exposed rats. The expression was normalized after clozapine treatment (5 mg/kg/day, postnatal day 35–56). These findings demonstrate that downregulation of several proteins in lead-exposed rats affected subsequent behavioral changes. Our results suggest that lead exposure in early life may induce psychiatric disorders and treatment with antipsychotics such as clozapine may reduce their incidence.
Animals
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Antipsychotic Agents
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Behavior Rating Scale
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Blotting, Western
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Clozapine
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Down-Regulation
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Drinking Water
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Female
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Hippocampus
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Incidence
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Interpersonal Relations
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Lactation
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Lead Poisoning
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Models, Animal
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Neurodevelopmental Disorders
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Pregnancy
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Rats
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Risk Factors