Objective To study the effect and reliability of venlafaxine on depression and anxiety symptoms in cervical cancer patient,and to assess the overall quality of life before and after treatment.Methods We treated 63 cervical cancer patients with depression by use of venlafaxine for 8 weeks,at the same time,evaluated their emotion state.change of quality of life and the adverse effect with HAMD,HAMA,TESS and laboratory tests.Results After 8 weeks.patients' scores of anxiety and depression decreased significantly from the baseline(P＜0.01),effective rates were 65%and 52%respectively.Three domains of quality of life(physiology,psychology and independence)became much better than those of baseline(P＜0.05).Conclusions This studyshows that venlafaxine can reduce the depression and anxiety symptoms in cervical cancer patients,and the react time is 2 to 4 weeks.Venlafaxine with the treatment of depression and enxiety can improve the quality 0f patients' life.