1.Scoping review of research trends in genetic factors related to metabolic syndrome in Koreans: using the data from Korean Genome and Epidemiology Study (KoGES)
Minyeong KIM ; Subin KIM ; Dayeon SHIN
Journal of Nutrition and Health 2025;58(1):131-152
Purpose:
Metabolic syndrome (MetS) is a condition in which multiple risk factors interact in a complex manner. Considerable attention has been directed towards the potential genetic contributions to its diverse mechanisms. Understanding these contributions is essential for reducing MetS and other chronic diseases and developing effective prevention strategies.Therefore, this study analyzed the research trends in academic papers exploring genetic factors related to MetS and its components in Koreans and attempted to identify areas requiring additional research.
Methods:
The scoping review method was used to evaluate studies that utilized the secondary data sets comprising the Korean Genome and Epidemiology Study. Articles published over the past 15 years were identified using the Research Information Sharing Service, Korean Studies Information Service System, DBpia, PubMed, and ScienceDirect databases.
Results:
Forty-seven published articles from 2010 to 2024 were included in the review.Research on the genetic factors linked to MetS has expanded since 2019, indicating significant advances in the field. The research included 18 studies on the polygenic risk score (PRS)/genetic risk score (GRS), 17 studies on single nucleotide polymorphisms (SNPs), six studies on two or more genes, four studies on DNA methylation, and two studies on copy number variations (CNVs). In PRS/GRS research, seven studies focused on the genes related to diseases. In SNP research, four studies examined the FTO gene. Studies on two or more genes included two studies, each on the genes associated with diabetes and high-density lipoprotein cholesterol. For DNA methylation, three studies focused on the TXNIP gene. Finally, in CNV research, one study was conducted on the LEPR gene and one on genes for hypertension.
Conclusion
The relatively low proportion of studies on DNA methylation and CNV presents limitations in understanding their associations with MetS. Expanded research utilizing diverse approaches and genetic variables is needed to overcome these limitations.
2.Scoping review of research trends in genetic factors related to metabolic syndrome in Koreans: using the data from Korean Genome and Epidemiology Study (KoGES)
Minyeong KIM ; Subin KIM ; Dayeon SHIN
Journal of Nutrition and Health 2025;58(1):131-152
Purpose:
Metabolic syndrome (MetS) is a condition in which multiple risk factors interact in a complex manner. Considerable attention has been directed towards the potential genetic contributions to its diverse mechanisms. Understanding these contributions is essential for reducing MetS and other chronic diseases and developing effective prevention strategies.Therefore, this study analyzed the research trends in academic papers exploring genetic factors related to MetS and its components in Koreans and attempted to identify areas requiring additional research.
Methods:
The scoping review method was used to evaluate studies that utilized the secondary data sets comprising the Korean Genome and Epidemiology Study. Articles published over the past 15 years were identified using the Research Information Sharing Service, Korean Studies Information Service System, DBpia, PubMed, and ScienceDirect databases.
Results:
Forty-seven published articles from 2010 to 2024 were included in the review.Research on the genetic factors linked to MetS has expanded since 2019, indicating significant advances in the field. The research included 18 studies on the polygenic risk score (PRS)/genetic risk score (GRS), 17 studies on single nucleotide polymorphisms (SNPs), six studies on two or more genes, four studies on DNA methylation, and two studies on copy number variations (CNVs). In PRS/GRS research, seven studies focused on the genes related to diseases. In SNP research, four studies examined the FTO gene. Studies on two or more genes included two studies, each on the genes associated with diabetes and high-density lipoprotein cholesterol. For DNA methylation, three studies focused on the TXNIP gene. Finally, in CNV research, one study was conducted on the LEPR gene and one on genes for hypertension.
Conclusion
The relatively low proportion of studies on DNA methylation and CNV presents limitations in understanding their associations with MetS. Expanded research utilizing diverse approaches and genetic variables is needed to overcome these limitations.
3.Scoping review of research trends in genetic factors related to metabolic syndrome in Koreans: using the data from Korean Genome and Epidemiology Study (KoGES)
Minyeong KIM ; Subin KIM ; Dayeon SHIN
Journal of Nutrition and Health 2025;58(1):131-152
Purpose:
Metabolic syndrome (MetS) is a condition in which multiple risk factors interact in a complex manner. Considerable attention has been directed towards the potential genetic contributions to its diverse mechanisms. Understanding these contributions is essential for reducing MetS and other chronic diseases and developing effective prevention strategies.Therefore, this study analyzed the research trends in academic papers exploring genetic factors related to MetS and its components in Koreans and attempted to identify areas requiring additional research.
Methods:
The scoping review method was used to evaluate studies that utilized the secondary data sets comprising the Korean Genome and Epidemiology Study. Articles published over the past 15 years were identified using the Research Information Sharing Service, Korean Studies Information Service System, DBpia, PubMed, and ScienceDirect databases.
Results:
Forty-seven published articles from 2010 to 2024 were included in the review.Research on the genetic factors linked to MetS has expanded since 2019, indicating significant advances in the field. The research included 18 studies on the polygenic risk score (PRS)/genetic risk score (GRS), 17 studies on single nucleotide polymorphisms (SNPs), six studies on two or more genes, four studies on DNA methylation, and two studies on copy number variations (CNVs). In PRS/GRS research, seven studies focused on the genes related to diseases. In SNP research, four studies examined the FTO gene. Studies on two or more genes included two studies, each on the genes associated with diabetes and high-density lipoprotein cholesterol. For DNA methylation, three studies focused on the TXNIP gene. Finally, in CNV research, one study was conducted on the LEPR gene and one on genes for hypertension.
Conclusion
The relatively low proportion of studies on DNA methylation and CNV presents limitations in understanding their associations with MetS. Expanded research utilizing diverse approaches and genetic variables is needed to overcome these limitations.
4.A Concept Analysis of Spiritual Self-Care in Hospice Team Members by Hybrid Model
Sunhee JANG ; Sungju LEE ; Minyeong KIM
Journal of Korean Academy of Psychiatric and Mental Health Nursing 2023;32(4):501-513
Purpose:
The study aimed to clarify the concept of spiritual self-care in hospice team members.
Methods:
To analyze the concept of spiritual self-care of hospice care team, the study was carried out using Schwartz-Barcott and Kim's hybrid model including theoretical, fieldwork and final analytic stages. In the theoretical stage, 'spirituality', 'spiritual well-being', 'spiritual health', 'spiritual care', and 'self-care' were set as search terms, and the resulting 107 related works of domestic and international literature were analyzed. In the field survey stage, data were collected from nurses and spiritual experts with more than 5 years of experience in spiritual self-care.
Results:
The concept of spiritual self-care is to realize the meaning and purpose of life while constantly maintaining relationships with oneself, neighbors, communities, and the absolute, utilize transcendence and internal resources, strengthen professional competence, maintain work-life balance, and achieve spiritual well-being. It was identified as a dynamic state to realize. The quality attributes of the concept of spiritual self-care were found to have 5 attributes and 15 indicators.
Conclusion
The attributes and indicators derived through this study will be helpful in understanding the concept of hospice team members' spiritual self-care. In addition, as a way to continuously grow and train professional hospice team members, it can be used to develop a spiritual self-care assessment tool and an educational program to prevent burnout.
5.Clinical Course of Suspected Diagnosis of Pulmonary Tumor Thrombotic Microangiopathy: A 10-Year Experience of Rapid Progressive Right Ventricular Failure Syndrome in Advanced Cancer Patients
Minjung BAK ; Minyeong KIM ; Boram LEE ; Eun Kyoung KIM ; Taek Kyu PARK ; Jeong Hoon YANG ; Duk-Kyung KIM ; Sung-A CHANG
Korean Circulation Journal 2023;53(3):170-184
Background and Objectives:
Several cases involving severe right ventricular (RV) failure in advanced cancer patients have been found to be pulmonary tumor thrombotic microangiopathies (PTTMs). This study aimed to discover the nature of rapid RV failure syndrome with a suspected diagnosis of PTTM for better diagnosis, treatment, and prognosis prediction in clinical practice.
Methods:
From 2011 to 2021, all patients with clinically suspected PTTM were derived from the one tertiary cancer hospital with more than 2000 in-hospital bed.
Results:
A total of 28 cases of clinically suspected PTTM with one biopsy confirmed case were included. The most common cancer types were breast (9/28, 32%) and the most common tissue type was adenocarcinoma (22/26, 85%). The time interval from dyspnea New York Heart Association (NYHA) Grade 2, 3, 4 to death, thrombocytopenia to death, desaturation to death, admission to death, RV failure to death, cardiogenic shock to death were 33.5 days, 14.5 days, 7.4 days, 6.4 days, 6.1 days, 6.0 days, 3.8 days and 1.2 days, respectively. The NYHA Grade 4 to death time was 7 days longer in those who received chemotherapy (7.1 days vs.13.8 days, p value=0.030). However, anticoagulation, vasopressors or intensive care could not change clinical course.
Conclusions
Rapid RV failure syndrome with a suspected diagnosis of PTTM showed a rapid progressive course from symptom onset to death. Although chemotherapy was effective, increased life survival was negligible, and treatments other than chemotherapy did not help to improve the patient’s prognosis.
6.Asymptomatic Myxoma Originating from the Right Ventricular Outflow Tract.
Dong Hwi KIM ; Jeong Eun YI ; Hyun Ji IN ; Minyeong JEONG ; Moon Sung KIM ; Joune Seup LEE ; Jong Hoon LEE ; Borami KANG ; Hae Ok JUNG ; Ho Joong YOUN
Journal of Cardiovascular Ultrasound 2013;21(4):186-188
Asymptomatic right ventricular outflow tract (RVOT) myxoma is quite rare. We report an unusual case of asymptomatic myxoma arising from the RVOT which was successfully surgically removed.
Echocardiography
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Heart Ventricles
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Myxoma*