Allergy-related diseases are common and frequently-occurring in children. Its onset follows the sensitization transfer rule from skin allergy to respiratory allergy, which is called the natural process of allergic disease or atopic march. The relationship between intestinal microbiota and allergic diseases has been a hot topic in recent years. Immunoregulation and neuromodulation with the participation of intestinal microbiota are two important aspects that affect the development of allergic diseases. Therefore, in this paper, we systematically reviewed the interaction of bacteria-immune-neural network in atopic march from the perspective of multi-system sensitization, so as to open up new perspectives for the mechanism research and prevention of sensitization progress.