Objective To analyze the features of adverse reactions of compatibility of 70 cases of TCM injections in Wuzhou Chinese Medicine Hospital;To provide references for reasonable medication.Methods Reports about adverse reaction caused by 70 cases of TCM injection compatibility in our hospital were under retrospective analysis, in order to summarize the features of adverse reactions and study coping strategies.Results The compatibility between TCM injections and transfusion, chemicals, TCM injections and biological medicine may cause adverse reactions. Among the 70 cases, the types of adverse reactions were 28 cases of skin system (40.00%), 18 cases of the digestive system (25.71%), 12 cases of central nervous system (17.14%), 4 cases of cardiovascular system (5.71%), the other 8 cases (11.43%). TCM injection with compatibility of adverse reactions were mainly compound Danshen Injection,Shenmai Injection,Tanreqing Injection,Qingkailling Injection,Danhong Injection andXuesaitong Injection.Conclusion The compatibility of TCM injections may cause unpredictable adverse reactions. Therefore, TCM injections should be used according to relevant regulations, with a purpose to ensure the security and effectiveness of TCM injections in clinic.

Objective To explore a novel long-circulating dual-receptor targeting and dual-modal molecular probe and investigate its physicochemical properties and targeting effect on breast cancer cells in vitro. Methods Dual-receptor targeting and dual-modal molecular probe RGD@BBN-lipo(QDs)-SPIO was synthesized in the following steps: long-circulating liposome was prepared by film dispersion method;water-soluble superparamagnetic iron oxide (SPIO) nanoparticles and Quantum dots (QDs) were loaded in the hydrophilic and hydrophobic layer of liposome, respectively;RGD and BBN polypeptides were coupled on the former functional magnetic/fluorescent liposomes. Stability of the probe in different physiological solutions was investigated. Transmission electron microscopy (TEM) and particle size analyzer were used to measure nanoparticle sizes and the Zeta potential. Characterization of RGD and BBN was investigated through 1H-NMR and elemental analysis. The MRI T2 relaxivities (1/T2) of RGD@BBN-lipo(QDs)-SPIO was measured through T2 map scanning on 3.0 T MR system. HUV-EC-C cells were used for assessment of cells viability by MTS assay. Prussian blue staining and fluorescence imaging were carried out to determine the targeted breast cellular uptake of RGD@BBN-lipo(QDs)-SPIO nanoparticles. Results The targeting magnetic/fluorescent dual-model molecular probes appeared spherical or para-spherical,with a mean diameter of(118.2±3.9)nm,Zeta potential of (-24.78±1.68) mV,MR T2 magnetic relaxation rate of 0.498 1× 106 M-1 · s-1.RGD and BBN polypeptides were successfully coupled on the former functionally magnetic/fluorescent liposomes with the bind rates of 33.05%and 45.06%, respectively. There was low cytotoxity of the molecular probe on human umbilical vein endothelical cells(HUV-EC-C)by MTS study. Prussian blue staining and fluorescence imaging studies showed that the RGD@BBN-lipo(QDs)-SPIO nanoparticles could target any αvβ3 or gastrin releasing peptide receptor overexpression breast cancer. Conclusions RGD@BBN-lipo(QDs)-SPIO is a novel long-circulating dual-receptor targeting and dual-modal molecular probe and has excellent physicochemical properties and stability, high T2 relaxivities and strong targeting effect on cancer cells and has laid a solid foundation for early diagnosis of breast cancer.