This study was aimed to carry the post-marketing revaluation on classical Tibetan medicine of the Seven-ty-flavor Pearl Pill, which will help improve its scientificity, safety and standardization in order to promote its indus- trial development. Literature mining method was used to summarize research information of the Seventy-flavor Pearl Pill, such as the clinical pharmacy sorting. Meanwhile, the successful example of Padma-28 was referred in the analysis of deficiencies in the indications of Seventy-flavor Pearl Pill. The results showed the present situation of clinical combination therapy, pharmacology and toxicology study of Seventy-flavor Pearl Pill. It was concluded that the building of new model of post-marketing revaluation on the Seventy-flavor Pearl Pill can provide re-evaluation scientific basis for Tibetan medicine on its clinical effectiveness and safety.

Objective: To explore the mechanism of traditional Chinese medicine(TCM) combined with regular therapy in the treatment of pneumonia with systemic inflammatory response syndrome(SIRS) in(children).Methods: Sixty-four children with pneumonia including 51 cases with SIRS complication were(randomly) divided into three groups: treatment group(regular therapy+TCM,n=26),control group Ⅰ((regular)(therapy) only,n=25) and the control groups Ⅱ(13 pneumonia children without SIRS(receiving)(routine) treatment). The dynamic changes of tumor necrosis factor-?(TNF-?),interleukin-6(IL-6) and IL-8 were measured before and after treatment in all children.Serum Creactive protein(CRP) and total white blood cell(WBC) count were measured simultaneously.Clinical symptom and sign scores were(performed)(5 days) after treatment in children with pneumonia and SIRS complication.Results: Before(treatment),serum TNF-?,IL-6,IL-8 and CRP concentrations were significantly higher in treatment group and(control) group Ⅰ than(control) group Ⅱ(all P

OBJECTIVETo review 204 consecutive free flap transfers for head and neck reconstruction in the new microsurgery unit.

METHODSTwo hundred and four consecutive free flap transfers performed in 192 patients form May 1999 to March 2001 were reviewed. The clinical data included the surgery date, defect description and site, stage and histology of the tumor, type of the flap used and complications.

RESULTSThe free redial forearm flap was the most commonly used, followed by the free fibula flap, rectus abdominis flap, iliac crest flap, and latissimus dorsi flap. The overall success rate was 98.5%. The overall complication rate was 29.7%. The vessel thrombosis rate was 5.4%, and the flap salvage rate was 72.7%.

CONCLUSIONFree tissue transfer in the head and neck region is safe and reliable. It is superior to the conventional pedicle flap technique.

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Head and Neck Neoplasms ; surgery ; Humans ; Male ; Middle Aged ; Postoperative Complications ; Surgical Flaps

OBJEC TIVE To optimize the simultaneous extraction technology of dietary fiber （DF）and flavonoids from the peel of Prunus armeniaca . METHODS The content of DF was calculated with enzyme-gravimetric method ，and the content of flavonoids was determined by ultraviolet spectrophotometry. The orthogonal design and single factor test were used to optimize the extraction technology ，with the factors of liquid-solid ratio ，pH，papain concentration ，α-amylase concentration ，temperature of enzymatic hydrolysis and time of enzymatic hydrolysis as factors ，using the contents of DF and flavonoids as indexes. RESULTS The optimal extraction technology included the solid-liquid ratio of 1 ∶ 10（g/mL），pH5，0.5％ papain and 0.5％ α-amylase， enzymatic hydrolysis at 50 ℃ for 1 h. After three times of validation ，the average content of DF was 0.801 g/g（RSD＝1.95％）， and the average content of flavonoids was 2.135 mg/g（RSD＝2.44％）. The average comprehensive score was 0.988（RSD＝ 0.81％）. CONCLUSIONS The optimal extraction technology is stable and feasible.