Purpose: We report a case of ocular toxoplasmosis that caused bilateral optic atrophy secondary to papillitis.Case summary: A 52-year-old male with no history of systemic disease was referred to our clinic because of visual field blurring in the left eye for four weeks. The visual acuity was 20/20 in the right eye and 20/25 in the left eye. A relative afferent pupillary defect and diffuse field loss were noted in the left eye. On fundus examination, left-side blurring of the disc margin and a peripapillary hemorrhage were evident, but there was no sign of inflammation in the right fundus. Systemic evaluation, including brain magnetic resonance imaging, was performed for differential diagnosis of left papillitis. Immunoserologically, he was positive for toxoplasma immunoglobulin (Ig)M and IgG. We diagnosed ocular toxoplasmosis presenting as left papillitis, and systemic antibiotics and a steroid were started. After six weeks, the left disc swelling was reduced but disc pallor was evident and his visual acuity decreased to 20/40. A new inflammatory lesion of the right optic disc developed two weeks after the medication was stopped, so the treatment was applied for a further two months. However, bilateral optic atrophy developed. Conclusions Bilateral papillitis caused by ocular toxoplasmosis may trigger optic atrophy secondary to optic nerve involvement.When a patient presents with disc swelling suggestive of papillitis caused by ocular toxoplasmosis, rapid and aggressive antitoxoplasma treatment is essential to avoid a poor visual outcome.

No abstract available.

Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca 2+ -permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease.

Background: With the increase in the number of single-person households, the number of people eating alone is increasing, and several previous studies have been published that this eating culture affects health, including the latest data on the risk of metabolic syndrome caused by eating alone. Methods: Of the 24,229 people who participated in the 2017-2019 National Health and Nutrition Survey, a cross-sectional study was conducted on 10,717 adults under the age of 65 who responded to questions to determine whether they ate together and metabolic syndrome for 1 year. Results: It was found that the risk of metabolic syndrome increased when eating alone, and further analysis by gender showed that the risk of metabolic syndrome increased in women as they ate alone (odds ratio, 1.46; 95% confidence interval, 1.210-1.771). As a result of dividing the metabolic syndrome indicators, it was found that men showed significant differences only in neutral fat levels, while women showed significant differences in all indicators. Conclusions According to the results of this study, it is found that eating alone affects the risk of metabolic syndrome in adults under the age of 65, especially women, so it is considered necessary to prevent and manage metabolic syndrome in the population of eating alone in the future.

OBJECTIVE: Self-esteem and self-consciousness are important determinants of behaviors. This study aimed to explore the relationship between self-esteem and self-consciousness in adolescents using the eye-tracking measurement. METHODS: Fifty-five adolescents with high self-esteem and 58 adolescents with low self-esteem participated in self-consciousness-related eye-tracking experiments of selecting happy, disgusted, and angry facial emotions while recognizing one's own usual expressions and the others' usual expressions toward oneself. RESULTS: When recognizing one's own, adolescents with high self-esteem showed significantly more selection counts and longer fixation time for ‘happy’ than adolescents with low self-esteem. When recognizing the others', adolescents with low self-esteem showed significantly more selection counts and longer fixation time for ‘disgusted’ and ‘angry’ than adolescents with high self-esteem. CONCLUSION: These suggest higher self-esteem is connected to more positive identification of one's usual expressions and others' usual expressions toward oneself. There is a close relationship among low self-esteem, suppressing positive emotions, decreased psychological adjustment, and increased negative emotions.
Adolescent ; Emotional Adjustment ; Humans

No abstract available.
Apraxias* ; Ataxia*

Unfortunately, the original version of this article contained an error in the nomenclature of a variant which was shown in an electropherogram in the Figure 1.

No abstract available.
Neurilemmoma* ; Thyroid Gland* ; Thyroid Nodule*

Background and Objectives: Proximal submandibular stone is not a rare disease. The aim of this study is to evaluate the surgical outcomes of 3 different ways to treat proximal submandibular stone: intraoral removal of stone (IORS) with sublingual gland (SLG) resection, IORS without SLG resection and submandibular gland (SMG) resection. Subjects and Methods: We prospectively reviewed the surgical outcomes of IORS with SLG resection group (22 patients), IORS without SLG resection group (35 patients) and SMG resection group (22 patients). To evaluate the surgical outcomes, we analyzed the location and size of stones, mean operation time, mean hospital stay, mean postoperative degree of pain based on a visual analog scale (0–10), and incidence of complications. Results: There were no significant differences between the mean diameter of stones and lengthfrom the hilum to stones. The mean operation time was shorter in the IORS without SLG re-section group than that in IORS without SLG resection group, and was significantly shorter than that of the SMG resection group. The mean hospital stay of the IORS without SLG resection group was also shorter than that of IORS with SLG resection group, and was significantly short-er than the SMG resection group. IORS without SLG resection group felt less pain than IORS with SLG resection group and SMG resection group. Four patients who underwent IORS without SLG resection experienced transient and mild SMG swelling, and mild paresthesia was noted on the same side. All patients recovered within 3 months. Intraoral removal of proximal SMG stones exhibited several advantages over SMG resection in terms of hospital stay, mean operation, time and postoperative pain. Conclusion Based on our results, we suggest that IORS without SLG resection be selected as the primary procedure for the removal of proximal submandibular stones rather than SMG resection.

BACKGROUND: It is recommended to use aerosolized (AS) colistin in patients undergoing mechanical ventilation therapy as an adjunctive in the latest guidelines, in spite of high nephrotoxicity and limited studies. In this study, systematic reviews and metaanalyzes were conducted to evaluate the safety and efficacy of AS colistin in patients with ventilator-associated pneumonia. METHODS: Two authors independently searched related literature published from Pubmed and EMBASE until July 2016 and included a study comparing adjunctive AS colistin with intravenous (IV) colistin monotherapy. The primary outcome was the clinical response rate, the secondary outcome was the overall mortality, and nephrotoxicity. The publication bias was evaluated using the Egger's test. RESULTS: Of the total 279 articles, nine were finally included in the final analysis. There was a significant difference between the adjunctive AS colistin group and the IV colistin monotherapy group for the treatment-response rate (odds ratio (OR), 1.56; 95% CI, 1.14–2.14; p = 0.005; I² = 36%), although there was no significant difference in overall mortality (OR, 0.77; 95% CI, 0.57–1.04; p = 0.09; I² = 20%). However, there was no significant difference between the two groups in nephrotoxicity (OR, 1.13; 95% CI, 0.74–1.74; p = 0.57; I² = 4%). CONCLUSION: The addition of aerosolized colistin to IV colistin monotherapy showed better results in terms of efficacy than IV colistin monotherapy and did not show any significant difference in terms of total mortality and nephrotoxicity. Additional large-scale studies of this need to be verified.