1.Regulatory effects of PB on sleep and wakefulness
Minrui ZHAO ; Dianru WANG ; Jieren YANG ; Yiqun WANG
Chinese Pharmacological Bulletin 2016;32(6):764-767
The parabrachial nucleus (PB)is made up of gray matter around the Pons combination(BC),mainly consisting of glutamatergic,GABAergic and enkephalinergic neurons.PB is connected to hypothalamus and basal forebrain through a network of nerve fibers.Specific lesion of the entire parabrachial complex in animals leads to a deep coma.PB also projects to the non-rapid eye movement(NREM)-related regions including the ven-trolateral preoptic,and receives the projections from the parafa-cial zone.Activation of the GABAergic neurons in parafacial zone can promote NREM sleep,which indicates that PB partici-pates in NREM sleep.Furthermore,the lateral PB is actived when rapid eye movement(REM)sleep is deprived.In conclu-sion,PB participates in regulating wakefulness, NREM and REM sleep.This review summarizes the advances in the roles of PB in sleep-wake regulation.
2.Measurement and algorithm of healthy life expectancy: a scoping review
Wanqi WANG ; Jinghan QU ; Mengze LIU ; Minrui LI ; Boying ZANG ; Junwen ZHOU ; Houyu ZHAO ; Rui ZHANG ; Yunning LIU ; Lijun WANG ; Xia WAN ; Feng SUN ; Jing WU
Chinese Journal of Epidemiology 2022;43(12):1986-1994
Objective:Healthy life expectancy (HLE), which combines life expectancy with health, is an essential comprehensive measure of life length and quality. This article aimed to systematically review the methods for defining and measuring HLE and describe application studies published, providing a reference for decision makers to select and develop methods suitable for China's conditions to measure HLE.Methods:Seven Chinese and English literature databases were searched up to May 7, 2022, and several related reviews and bibliography were manually retrieved. Systematic reviews and empirical research were included concerning HLE indicators and measurement of HLE. Information including the study area, type of the study, study population, HLE index, measurement method, data sources, and results from application studies published in the last five years were extracted. The evolution of the definition of HLE, the scope of different indicators, the measurement scale of health, and measurement methods, were all collected. Results of the empirical research related to measurement methods of indicators were summarized. The study followed the scoping review framework and was written according to the PRISMA-ScR statement.Results:A total of 84 articles were included, including 13 reviews, 17 original studies related to HLE index definition, ten original studies related to index measurement, and 44 empirical studies conducted in the past five years. There were as many as 20 indicators related to HLE, and each scale had its emphasis. A total of ten methods measuring HLE were identified, which vary in the definition of health, whether using weight, and the data type. The most commonly used indicators in the past five years were disability-free life expectancy and HLE. For the method of HLE calculation, Sullivan's method was mainly used for cross-sectional data, and the multistate life table was mainly used for longitudinal data.Conclusions:There are various definitions and measurement methods of HLE, but none are suitable for all scenarios. To summarize the HLE concept, health evaluation techniques, measurement methods, and application studies published worldwide can provide a reference for the localization of HLE measurement in China.
3.Progress in research of specific antibody dynamic characteristics in patients with COVID-19
Hongting ZHAO ; Zhibin PENG ; Xiaokun YANG ; Zhili LI ; Minrui REN ; Ying QIN ; Xiaojin SUN ; Jianxing YU ; Zhijie AN ; Naiying MAO ; Wenbo XU ; Zhongjie LI
Chinese Journal of Epidemiology 2021;42(1):39-43
COVID-19 is an emerging infectious disease caused by SARS-CoV-2. After the infection of the virus, the host immune system is stimulated to produce multifarious specific antibodies to decrease or eliminate effects of the pathogen. Study of the specific antibodies dynamic characteristics in patients with COVID-19 is very important for the understanding and diagnosis of the disease, research and development of vaccine, and planning of prevention and control strategy. This paper reviews and summarizes the domestic and oversea research on dynamic characteristics of specific antibodies of COVID-19 patients, including the antibody producing, duration and level, and its possible influencing factors in order to improve the understanding of the immunological characteristics of COVID-19.
4.Clinical correlations with disease-associated auto-antibodies in a Chinese cohort with systemic sclerosis.
Sen YANG ; Minrui LIANG ; Chen CHEN ; Wenjing YE ; Xiaoxia ZHU ; Yu XUE ; Ning KONG ; Yiyun YU ; Dandan XUAN ; Shucong ZHENG ; Xue YANG ; Zaihua ZHU ; Tianyi ZHAO ; Weiguo WAN ; Hejian ZOU
Chinese Medical Journal 2022;135(15):1878-1880