Objective To study the application effect of comprehensive nursing intervention in elderly intestinal polyps enucleation. Methods A total of 78 elderly patients with intestinal polyps enucleation were randomly divided into con-trol group(n=39) and observation group (n=39), two groups were given routine nursing,observation group was given com-prehensive nursing intervention based on routine nursing. Results SAS and SDS scores of the observation group after nursing intervention were (37.43±5.63)scores and (48.82±7.46)scores, those were lower than (52.16±8.37)scores and (52.16±8.31)scores of the control group (P<0.05). Intestinal polyps knowledge awareness and nursing satisfaction of ob-servation group were 94.87%and 97.44%, higher than 79.49% and 82.05% of the control group (P<0.05). Conclusion Comprehensive nursing intervention in elderly patients with intestinal polyps enucleation during perioperative can effec-tively relieve patients' anxiety and depression, and improve the recognition of intestinal polyps and nursing quality.