Objective To evaluate the value of color flow angio(CFA)in judging the status of thyroid function by analyzing the ultrasonographic features and quantitatively measuring the blood flow signals in patients with thyroid diffuse lesions.Methods Totally 100 patients with thyroid diffuse lesions diagnosed by ultrasonography between Oct.2016 and Jun.2017 were divided into three groups:hyperthyroidism group(n=30),hypothyroidism group(n=34)and euthyroid group(n=36).Moreover,30 cases of healthy volunteers were chosen as control group.The blood flow index including vascularity index(VI)value and Vascularity value of region of interest from all cases was measured through CFA imaging technique.The differences of VI and Vascularity from above 4 groups were compared using one-way analysis of variance.Comparison among groups was carried out by SNK-q test.The subjects' work curves(ROC curves)were plotted and analyzed using clinical diagnosis as gold standard.At the same time,the correlation between VI and thyroid function in hyperthyroid group and hypothyroidism group was analyzed through Pearson correlation coefficient.Results The levels of VI and Vascularity in hyperthyroid group,hypothyroid group,euthyroid group and control group were decreased gradually with significant differences between every two groups.VI : control vs hyperthyroid,hypothyroid and euthyroid group: q=13.67,7.00 and 3.93,all P＜0.01.Euthyroid vs hyperthyroidism and hypothyroid group: q=10.35,P＜0.01 and q=3.27,P＜0.05.Hyperthyroidism vs hypothyroid group: q=7.09,P＜0.01.Vascularity: control vs hyperthyroid,hypothyroid and euthyroid group: q=15.23,10.16 and 6.58,all P＜0.01.Euthyroid vs hyperthyroidism and hypothyroid group: q=9.33 and 3.83,both P＜0.01.Hyperthyroidism vs hypothyroid group: q=5.55,P＜0.01.The area under the curve of hyperthyroidism group and hypothyroidism group was 0.733,with 9.526%as the diagnostic cutoff point.The sensitivity and specificity were 70.0%and 76.5%respectively.The area under the curve of the abnormal group and normal group was 0.768,with 7.404%as the diagnostic cutoff point.The sensitivity and specificity were 62.5%and 88.9%,respectively.The VI value of hyperthyroidism group was positively correlated with FT3 and FT4(r=0.584,0.499,both P＜0.05),and negatively correlated with TSH(r=-0.447,P＜0.05).The VI value of hypothyroidism group was negatively correlated with FT4(r=-0.342,P＜0.05),and had no significant correlation with FT3 and TSH(r=0.121,-0.007,P＞0.05).Conclusion CFA imaging technology can quantitatively measure the blood flow signals of thyroid parenchyma and evaluate the thyroid function in patients with thyroid diffuse lesions.

Objective To observe the value of multimodal ultrasound for dynamic evaluating the therapeutic effect of neoadjuvant chemotherapy(NACT)for breast cancer.Methods Data of 50 patients with single breast cancer who underwent complete NACT were retrospectively analyzed.The patients were divided into major histological response(MHR)group(n=26)and non-major histological response(NMHR)group(n=24)according to postoperative pathology.The changes of ultrasonic indicators of lesions before NACT and during the early,middle and late periods of NACT were comparatively observed between groups,so as the reduction rates of quantitative indicators during NACT between groups and within groups.Results After NACT,the maximum diameter of lesions,as well as the changes of lesions'maximum(Emax)and the mean(Emean)value of Young's modulus were significant different(all P＜0.05),while no significant difference of lesions'reduction modes nor blood flow classifications was found between groups(both P＞0.05).At early,middle and late periods of NACT,progressive reduction rate(PRR)of the maximum diameter of lesions in MHR group showed a decreasing trend,while showed decreasing trend at the middle but increasing trend at the later period of NACT in NMHR group.The total reduction rate(TRR)and PRR of lesions with the maximum diameter ≥2 cm(n=3,9)at all period of NACT were higher than those with the maximum diameter ＜2 cm in both groups(n=23,15,all P＜0.05).At early,middle and late periods of NACT,PRR of Emax and Emean within both groups showed gradually increasing trends,while TRR and PRR at all periods of NACT with Emax decreased ≥30％ lesions(n=14,5)were all higher than those with Emax decreased ＜30％ lesions(n=12,19),TRR and PRR at all periods of NACT of Emean decreased ≥30％ lesions(n=18,7)were all higher than those with Emean decreased ＜30％ lesions within both groups(n=8,17,all P＜0.05).Conclusion Multimodal ultrasound could be used to dynamically evaluate the efficacy of NACT for breast cancer,hence guiding the formulation of individualized treatment planning.