1.SWOT analysis on the development and utilization of Li medicine resources in Hainan Province
Duobo WU ; Fangyuan HU ; Lei ZHANG ; Minlin ZHAO ; Mingyu XU ; Linping XIONG
Journal of Pharmaceutical Practice 2017;35(5):433-437
Objective To study the development and utilization of Li medicine resources in Hainan Province, analyze the existing problems and present specific suggestions for the rational exploitation and utilization of Li medicine resources.Methods SWOT analysis was carried out on the development and utilization of Li medicine in Hainan by means of literature analysis and field survey.Results The advantage of Li medicine lies in its long history and sufficient resources.The complicated ethnic factors within Li nationality hindered the development of Li medicine and resulted in the lack of basic research.Although the relevant policies and market demands have brought opportunities for the development of Li medicine, the rapid development of society may pose a potential threat to the development and protection of Li medicine resources.Conclusion The unique advantages of Li medicine ought to be used to create Li medicine brand.While Hainan is building its international tourism island, the health benefits of Li medicine should be promoted.Through the creation of Li medicine schools or departments, new professionals need to be trained to continue the development and utilization of Li medicine.
2.Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy.
Minlin JIANG ; Keyi JIA ; Lei WANG ; Wei LI ; Bin CHEN ; Yu LIU ; Hao WANG ; Sha ZHAO ; Yayi HE ; Caicun ZHOU
Acta Pharmaceutica Sinica B 2021;11(10):2983-2994
Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-L1) and interact with signaling such as cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling. Here, we review the basic knowledge of DDR pathways, mechanisms of genomic instability induced by DDR alterations, impacts of DDR alterations on immune system, and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.