Objective:To observe the curative effect of vinpocetine combined with Danhong injections in the treatment of posterior circulation ischemia syndrome. Methods:Totally 120 patients with posterior circulation ischemia syndrome were selected and randomly divided into the treatment group and the control group with 60 cases in each. Both groups were treated by the conventional therapy, meanwhile, the treatment group was given vinpocetine and Danhong injections, and the control group was given vinpocetine alone. The treatment course was 14 days. The curative effect was observed, blood rheology and hemodynamics were also studied. Results:The to-tal effective rate of the treatment group was 95. 0%, which was significantly higher than that of the control group (75. 0%) with statis-tically significant difference(P<0. 05). After the treatment, the blood rheology (viscosity, low shear viscosity, plasma viscosity and reduced viscosity) and TCD ( LVA, RVA, BA and PI) in the two groups were significantly improved, and the treatment group showed more significant improvement(P<0. 05). Conclusion:Vinpocetine combined with Danhong injections in the treatment of posterior cir-culation ischemia syndrome has significant effect in the effective improvement of blood rheology and hemodynamics, which is worthy of clinical promotion and application.

Purpose To observe therapeutic effect of electroacupuncture Neixiyan (Ex-LE 4 ) and Dubi (ST 35) in treating osteoarthritis of knee joint. Method All the 120 cases were randomly divided into electroacupuncture and control groups, 60 cases in each group,and they were given electroacupuncture and Ritalin slowreleased tablet respectively, and pain, mobility and swelling degree of knee joint were observed before and after treatments. Results In treatment group, the average score increased by 18, while in control group, it increased by 12.33 ( P < 0. 05 ) after treatment. Conclusion Therapeutic effect of electroacupuncture Neixiyan (Ex-LE 4) and Dubi (ST 35) in treating osteoarthritis of knee joint was better than that of administration of Ritalin slow-released tablet.

Objective　The study aims to explore the value of insulin resistance（IR）in predicting the occurrence of cerebral small vessel disease（CSVD）.Methods　A total of 172 patients were enrolled in the Affiliated Hospital of Jiaxing University from August 2019 to December 2020.HOMA-IR index was calculated according to the formula and the 3.0 value was the cut-off point of IR.All patients were divided into CSVD group and non-CSVD group or IR group and non-IR group.The total CSVD score was calculated according to the presence of each CSVD feature on MR from 0 to 4 using a recent described score rule.The relationship between CSVD and HOMA-IR was analyzed via the dichotomy logistic method.And the receiver operating characteristic curve (ROC curve) was used to evaluate the accuracy and specificity of HOMA-IR for predicting CSVD.Results　The results showed the IR ratio rises with the increase of CSVD score.We compared the difference in the proportion of IR between mild CSVD and moderate-to-severe CSVD with the result of 44.1% vs 66.1% (P<0.05).HOMA-IR in non-CSVD group was significantly lower than those in CSVD group 1.9 (IQR:1.0~4.2) compared with 3.7 (IQR:1.5~5.1)(P<0.05).The result of OR value for multiple logistic regression analysis was 1.18 (95%CI 1.01~1.38)(P<0.05).ROC curve shows the sensitivity and specificity of the optimal cut-off value,marked as 2.54,were 65.25% and 62.96% (P=0.004).Conclusion　IR has a certain predictive value in the diagnosis of CSVD.It is involved in the pathogenesis and progression of CSVD.