Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.
Basophils ; Dendritic Cells* ; Helminths ; Humans ; Interleukin-4 ; Lymphocytes ; Th1 Cells ; Th17 Cells ; Th2 Cells*

BACKGROUND: The measurement of grip strength is a simple and inexpensive method to assess all-cause and cardiovascular mortality, as well as the risk of cardiovascular disease. We investigated the association between handgrip strength and the risk of cardiovascular disease in a nationally representative sample.METHODS: Using the Seventh Korea National Health and Nutrition Examination Survey 2016, we analyzed data obtained from 3,266 adults aged 40–79 years, without cardiovascular disease at their baseline examination (1,421 men and 1,845 women). Relative handgrip strength was used for analysis and was calculated as the sum of the maximal absolute handgrip strength of both hands divided by the body mass index. We performed multivariate linear regression analysis to assess the association between handgrip strength and the 10-year risk of cardiovascular disease. The 10-year risk of cardiovascular disease was calculated using the American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort atherosclerotic cardiovascular disease (ASCVD) Risk Estimator.RESULTS: Multivariate linear regression analysis showed a significant association between handgrip strength and the 10-year risk of cardiovascular disease (%). After adjusting for confounders, an inverse association was observed between handgrip strength and the 10-year risk of cardiovascular disease in adults of both sexes (men: −1.29, women: −0.58).CONCLUSION: This study investigated the association between relative handgrip strength and the risk of ASCVD using ACC/AHA guidelines. We observed that increased relative handgrip strength may be associated with a better cardiovascular disease risk profile and lower 10-year cardiovascular risk among Korean adults aged 40–79 years.
Adult ; Body Mass Index ; Cardiovascular Diseases ; Cohort Studies ; Female ; Hand Strength ; Hand ; Heart ; Humans ; Korea ; Linear Models ; Male ; Methods ; Mortality ; Nutrition Surveys ; Risk Assessment

Forehead flaps are widely used to reconstruct nasal defects. The authors report a case wherein a folded forehead flap was used to reconstruct a large nasal defect after wide excision of squamous cell carcinoma. A 65-year-old man was diagnosed with squamous cell carcinoma by a punch biopsy conducted at the dermatology department, and the mass was located in the left nasal vestibule. A forehead flap was planned to cover the full-thickness defect that occurred after wide excision. A flap with an extended transverse skin paddle was designed; thereafter, the distant part of the flap was folded up to the nasal lining inside the nose. The interpolation flap was properly maintained for 3 weeks, and flap division was performed. The reconstructed nose exhibited symmetry during a 5-month observation period. A folded forehead flap is a surgical option when considerable nasal restoration, including soft tissue and the internal lining, is necessary.

OBJECTIVE: To evaluate the feasibility of robot-assisted laparoscopic myomectomy in multiple myomas over 10. METHODS: A retrospective study was conducted for 662 patients who underwent robot-assisted laparoscopic myomectomy and open myomectomy by a single operator in a tertiary university hospital. RESULTS: A total of 30 women underwent removal of 10 or more uterine myomas by robotics and 13 patients were selected for this study. The average number of myomas removed was 13.7 (range 10–20). The maximum diameter of the myomas was 6.8 cm (range 5.0–10.0 cm). The sum of the diameters of each myoma was 34.7 cm (range 20.0–54.5 cm) and the mass of resected myomas for each case was 229.1 g (range 106.8–437.9 g). In no case was the robotic procedure converted into conventional laparoscopy or laparotomy, and all patients recovered without any major complications. In comparison with 13 cases of open myomectomy during the same period, robotic surgery took longer time than open surgery (360.5 vs. 183.8 minutes; P=0.001) but had shorter postoperative hospital days after surgery (mean 2.5 vs. 3.5 days; P=0.003). CONCLUSION: Robot-assisted laparoscopic myomectomy could be an alternative to laparotomic myomectomy for numerous myomas over 10 in number.
Female ; Humans ; Laparoscopy ; Laparotomy ; Leiomyoma ; Minimally Invasive Surgical Procedures ; Myoma ; Retrospective Studies ; Robotic Surgical Procedures ; Robotics ; Uterine Myomectomy

Angioleiomyoma is a rare type of leiomyoma variant and there are a few cases reported to date. Herein, we present a case of angioleiomyoma in a 36-year-old woman with lower abdominal pain, initially diagnosed by degenerated uterine leiomyoma. The transvaginal ultrasonogram showed an ovoid-shaped heterogeneously hyperechoic lesion in left cornual site of uterus and pelvic magnetic resonance image showed an about 5.1 cm sized heterogenous T2 intermediate high mass with poor enhancement. The patient underwent a robot-assisted laparoscopic myomectomy, and final histopathologic diagnosis revealed uterine angioleiomyoma. This case is the first case of angioleiomyoma resected by robotic surgery. The patient is on follow up for over 1 year and shows no evidence of recurrence until now.
Abdominal Pain ; Adult ; Angiomyoma* ; Diagnosis ; Female ; Follow-Up Studies ; Humans ; Leiomyoma ; Recurrence ; Robotic Surgical Procedures ; Ultrasonography ; Uterine Myomectomy ; Uterus