Objective:To observe the efficacy of enteral nutritional suspensions in the patients with severe stroke. Methods:To-tally 823 cases of severe stroke patients were divided into the observation group and the control group according to the visiting se-quence. The 423 cases in the observation group were treated with enteral nutritional suspensions, while another 400 patients in the con-trol group were given the home-made meals with nasal feeding, and relative routine treatment was given the patients according to the disease type in the two groups. Before and after the treatment, serum total protein ( TB) , hemoglobin ( HB) , serum albumin ( ALB) and TG of the two groups were recorded, neurological deficit scores ( NIHSS) , Barthel index, muscle recovery and complications were also studied and compared. Results:After the treatment, TB, HB, ALB and TG of the two groups were significantly decreased ( P<0. 05), while the nutritional indicators in the observation group were significantly higher than those in the control group (P<0. 05). After the treatment, NIHSS score of the two groups was significantly decreased (P<0. 01), Barthel index was significantly increased (P<0. 01), and those in the observation group were better than those in the control group (P<0. 05). The muscle recovery of the observation group was significantly higher than that of the control group (P<0. 05). There was no significant difference in the compli-cations between the two groups(P>0. 05). Conclusion: Enteral nutritional suspensions can improve the nutritional status of the pa-tients with severe stroke with fewer complications and better safety, which are worthy of clinical application.