The hormone ghrelin is secreted mainly by stomach ,and is the only nature ligand that had been found by now for growth hormone releasing hormone receptor. Although the action for stimulating the secretion of growth hormone is very strong, it's only one part of ghrelin's action. It has many other actions in pathology and physiology, some of which are independent of it's stimulation to growth hormone releasing, such as regulating appetite, maintaining the energy equilibrium etc. We can find ghrelin's action in many human disease. This article is a review for the study in these parts.

Objective:To explore the levels of serum leptin,adiponectin and resistin in simple obesity and also to investigate their roles in this disease. Methods:The serum adiponectin,resistin,leptin,anthropometric and biochemical measurements of fasting blood glucose,fasting insulin were detected in 31 simple obesity subjects and 30 normal subjects. Results:① The adiponectin level in obesity group was significantly lower than that in normal group,but levels of leptin and resistin were higher(P