Objective To explore the effect of extended care on the quality of life of patients with permanent colostomy . Methods Clinical data of 268 patients with permanent colostomy were retrospectively analyzed. The patients were randomly divided into the experiment group (n=154) and control group (n=114). Two groups of patients after colostomy were given conventional nursing and telephone follow-up and the experiment group also received extended care such as home visits , seminars and fraternity care. Postoperative follow-up was done for 1 month, 3 months, 6 months, 9 months and 1 year. Core quality of life questionnaire (QLQ C30) was used to investigate the patients after 1 year intervention. Result Compared with the control group, patients′physical function, role function, emotional function, cognitive function, social function and health status rating were significantly improved in the experiment group (P<0.05). Conclusion Extended nursing can provide more comprehensive, systematic, professional nursing, improve the mastery of relevant knowledge and the skills and finally improve patients′quality of life.

Objective To investigate the incidence of white matter lesions(WML) in acute ischemic stroke ,and to analyze its the risk factors .Methods Totally 248 cases of acute ischemic stroke patients were selected ,patients′general information were in‐vestigated ,the WML severity with Fazekas rating scale were evaluated and patients were divided into severe group and no severe group according to the results ,the differences of general information between two groups were compared ,the severe WML was set as dependent variable ,the risk factors were ananlzed by multiariable Logistic regression analysis .Results There were 106 cases se‐vere WML patients among 248 cases acute ischemic stroke ,the incidence was 42 .74% ;single factor analysis found that the age in severe group was significantly higher than non severe group ,the incidence of hypertension ,diabetes in severe group was significantly higher than non severe group ,the difference was statistical significance (P<0 .05);multiariable Logistic regression analysis showed that age (OR=4 .116 ,95% CI:1 .816-6 .454 ,P=0 .000) ,hypertension (OR=1 .462 ,95% CI:0 .842-1 .946 ,P=0 .026) and dia‐betes (OR=1 .157 ,95% CI:0 .698-1 .673 ,P=0 .038)were the independent risk factors of severe WML in acute ischemic stroke . Conclusion The incidence of severe WML in acute ischemic stroke patients is high ,we need to targeted prevention measures on ol‐der age ,hypertension ,diabetes mellitus patients to reduce severe WM L occurred .