1.Combination of penetrating keratoplasty, cataract extraction and intraocular lenses implantation
Minjie SHENG ; Yiren ZHENG ; Anjuan LIN ; Ying CHEN ; Huixin CHEN ; Moqin WANG ; Chen QU ; Yufeng GUAN
Recent Advances in Ophthalmology 2000;20(6):407-409
Objective To observe the therapeutic effect of combination of penetrating keratoplasty, cataract extraction and intraocular lenses implantation.Methods Penetrating keratoplasty was performed simultaneously with cataract extraction and intraocular lenses implantation on 134 cases. Results One hundred and twenty cases were recorded after following up for 0.5~12 years. Ninety-nine cases (82.5%)of the corneas remained clear. Twenty-one cases (17.5%)of the corneas failed.Ninety-two cases (76.7%)achieved a better visual acuity postoperatively.Eighty-nine eyes(74.2%)were not blind any longer. Conclusion The combination of penetrating keratoplasty, cataract extraction and intraocular lenses implantation offers advantages of rapid and better rehabilitation of visual acuity with low complication rate.
2.The correlation of miR-100 expression with lymph node metastasis and FZD-8 protein expression in patients with breast cancer
Zhaojin YU ; Qian JIANG ; Li HAN ; Shu GUAN ; Yuanyuan YAN ; Minjie WEI ; Miao HE
Tianjin Medical Journal 2016;44(4):394-396
Objective To evaluate the expression and relationship of miR-100 and FZD-8, one of the major compo?nents of Wnt signaling pathway, and the correlation of their expressions with lymph node metastasis in patients with breast cancer. Methods The expression of miR-100 was determined in 50 samples of human breast cancer tissues and adjacent normal tissues by in situ hybridization. The correlation of miR-100 expression with lymph node metastasis was analyzed by Mann-Whitney U test. The expression of FZD-8 was measured in 50 samples of human breast cancer tissues and adjacent normal tissues by immunohistochemistry. The correlation of the miR-100 expression with the protein expression of FZD-8 was evaluated by Pearson rank analysis. Results The expression of miR-100 was significantly lower in human breast can?cer tissues than that in adjacent normal breast tissues [2.00 (1.00, 3.00) vs. 6.00 (3.50, 8.00)]. The miR-100 expression was lower in patients with lymph node metastasis than that in patients without lymph node metastasis [1.50 (1.00, 2.75) vs. 3.00 (2.00, 4.00)]. The expression of FZD-8 was significantly higher in human breast cancer tissues than that in adjacent normal breast tissues [8.00 (6.00, 9.00) vs. 6.00 (3.75, 9.00)]. The miR-100 expression was negatively correlated with the FZD-8 pro?tein expression in human breast cancer tissues (rs=-0.592, P<0.001). Conclusion The miR-100, as an anti-metastasis-miRNA, may involve in the metastasis of breast cancer, which may be related with the regulation of the expression of FZD-8.
3.Changes of pulmonary function after bone injury treated with polymethylme-thacrylic bone cement
Jikui GUAN ; Li ZHAO ; Yu JIANG ; Zebao LI ; Pengcheng CHAO ; Minjie WEI ; Hui WANG ; Jianguo LIU
Chinese Journal of Tissue Engineering Research 2013;(25):4727-4732
10.3969/j.issn.2095-4344.2013.25.023
4. Protective effects of N-acetyl-L-cysteine against binge drinking-induced fatty liver in mice
Mo XIAO ; Rui YANG ; Minjie GUAN ; Ning ZHAO ; Keqin XIE ; Tao ZENG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2018;36(3):169-173
Objective:
To investigate the roles of N-acetyl-L-cysteine (NAC) against binge drinking-induced fatty liver in mice.
Methods:
SPF male C57BL/6 mice were randomly divided into 3 groups, i.e. control group, model group, and NAC/ethanol group (