Dopamine transporters (DAT) uptake neurotoxic substances such as 1-methyl-4-phenylpyridinium (MPP) in the dopaminergic nerve terminals and may confer susceptibility to cytotoxic effects of neurotoxic substance. The association of a variable number tandem repeat polymorphism in the DAT gene with Parkinson's disease (PD) in a Korean population was studied. The 10-copy allele was the most common, accounting for 77.2+ACU- and 81.6+ACU- of alleles in PD patients and control subjects, respectively. The rare 11-copy allele was more common in the patients (odds ratio +AD0- 2.5, 95+ACU- confidence interval +AD0- 1.1-5.7, p+ADw-0.02). It is suggested that the 11-copy allele of the DAT gene may confer susceptibility to PD for some patients in Korea.
Aged ; Alleles ; Carrier Proteins/genetics+ACo- ; Case-Control Studies ; Comparative Study ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Human ; Korea/epidemiology ; Male ; Middle Age ; Minisatellite Repeats+ACo- ; Odds Ratio ; Parkinson Disease/genetics+ACo- ; Parkinson Disease/epidemiology

Dopamine transporters (DAT) uptake neurotoxic substances such as 1-methyl-4-phenylpyridinium (MPP) in the dopaminergic nerve terminals and may confer susceptibility to cytotoxic effects of neurotoxic substance. The association of a variable number tandem repeat polymorphism in the DAT gene with Parkinson's disease (PD) in a Korean population was studied. The 10-copy allele was the most common, accounting for 77.2+ACU- and 81.6+ACU- of alleles in PD patients and control subjects, respectively. The rare 11-copy allele was more common in the patients (odds ratio +AD0- 2.5, 95+ACU- confidence interval +AD0- 1.1-5.7, p+ADw-0.02). It is suggested that the 11-copy allele of the DAT gene may confer susceptibility to PD for some patients in Korea.
Aged ; Alleles ; Carrier Proteins/genetics+ACo- ; Case-Control Studies ; Comparative Study ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Human ; Korea/epidemiology ; Male ; Middle Age ; Minisatellite Repeats+ACo- ; Odds Ratio ; Parkinson Disease/genetics+ACo- ; Parkinson Disease/epidemiology