In order to evaluate how multitherapy affects on epidemiological picture of leprosy in Kh¸nh Hßa province, the authors have researched disease documents of 1.813 leprotic patients at Kh¸nh Hßa Provincial Dermatological Hospital from 1985 - 1999. They also carried out a sociological investigation from 2.847 normal people and 724 patients. Smear skins of 117 leprosy patients were collected randomly to find out ADN of Mycobacterium leprae by Polymerasa Chain Reaction (PCR) technique. Results showed: Using multitherapy with the combination of three drugs (Rifampicine, Clofazimine and Dapsone) have cut down leprosy incidence, detected new patients rate, under 15 year-old patients rate among new one yearly. It has increased the average age of detected new patients. It has also increased the rate of new patient register themselves in the past fifteen years. However, 5% PCRs of MB patients who stopped using multitherapy 5 years ago are still positive. This fact makes us to pay more attention on relapse of the disease, especially to whom with BI above 4+
Leprosy ; Leprostatic Agents ; epidemiology

The situation of the supplying curative and preventive medicine in Kh¸nh Hßa province was studied during 1993-1998: The average money for drug per capita, the network for drug selling in the local level, the activities of drug and treament commission in the district and provincial level and in some professional medical units, and the medical equipments are evaluated. From which, it should produce the orientations for strengthening national drug policy in locality
Pharmaceutical Preparations ; Public Policy

A new compound, 3β-acetoxylanosta-7,9(11),24-triene-26-al (3), and seven known compounds (1 – 2 and 4 – 8) were isolated from Ganoderma tropicum (Jung.) Bres. collected in Tay Nguyen, Vietnam. The structures of these compounds were determined by one- and two-dimensional nuclear magnetic resonance spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and high-resolution ESI-MS, and by comparison with literature data. All of the isolated compounds were tested for nitroblue tetrazolium (NBT) reduction activity in Saccharomyces cerevisiae-stimulated RAW 246.7 cells. Among them, compounds 2 – 4 and 6 – 8 enhanced the NBT reduction in a dose-dependent manner.

A new compound, 3β-acetoxylanosta-7,9(11),24-triene-26-al (3), and seven known compounds (1 – 2 and 4 – 8) were isolated from Ganoderma tropicum (Jung.) Bres. collected in Tay Nguyen, Vietnam. The structures of these compounds were determined by one- and two-dimensional nuclear magnetic resonance spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and high-resolution ESI-MS, and by comparison with literature data. All of the isolated compounds were tested for nitroblue tetrazolium (NBT) reduction activity in Saccharomyces cerevisiae-stimulated RAW 246.7 cells. Among them, compounds 2 – 4 and 6 – 8 enhanced the NBT reduction in a dose-dependent manner.