Incidence of Uveal melanoma (UM),is only secondary to cutaneous melanoma and is common primary intraocular malignant tumor of in adults.Recent studies suggest that its occurrence is related with gene mutation,chromosome aberrations and molecular pathway abnormalities.The mutations include GNAQ gene, GNA11 gene,microRNA (miRNA) (miR-34a, miR-182, miR-137).Mutations of GNAQ gene and GNA11 gene activate relevant pathways,such as MEK/ATK pathway,to promote UM metastasis, which makes the poor prognosis.Different miRNAs target the correspending genes and affect the prognosis.And the mutations of telomerase reverse transcriptase,all of them adjust the specific molecular pathways to affect tumor occurrence, development, metastasis and prognosis.Molecular genetic studies confirm that most patients with UM have chromosome 1,3,6,8,9 alterations,making the chromosome gain or less, leading to more susceptible invasion and metastasis and influencing prognosis.This paper reviewed the gene mutation and chromosome aberrations in order to provide new targets for the treatment of UM.

Objective To observe the influence of Wenxin Capsules on mean platelet volume (MPV) and platelet distribution width (PDW) in rats with coronary heart disease classified as heart-yang deficiency.Methods Rat model with coronary heart disease classified as heart-yang deficiency were established by gavage of high fat diet,subcutaneous injection of pitutrin and cold stimulation. Effects of Wenxin Capsules on the morphology of MPV and PDW were observed. Results MPV and PDW were decreased in Wenxin Capsules group (P

Objective To explore nursing for defecation of the patients with hip or knee replacement before and after arthroplasty.Methods 30 patients with selective bilateral hip or knee replacement were observed at different phases, including interval time, duration, score of oneself subject feeling, and rate of negative symptoms.Results ① Interval time and duration of defecation was longer after arthroplasty than before arthroplasty (P<0.05)；The index mentioned above of the second defecation was shorter than the first one(P<0.05). ②The score of oneself subject feeling and rate of negative symptoms were higher after arthroplasty than before arthroplasty(P<0.05); The index mentioned above of the second defecation was lower than the first one(P<0.05).Conclusion Difficult defecation happens to the patients with arthroplasty and the nurse should screen susceptible patients before operation, then highlight the key links and give nursing intervention in order to assist defecation.

The sub-health status is closely related to the functions and activities of heart in traditional Chinese medicine (TCM). The sub-health is commonly presented with a series of heart system symptoms such as palpitation, chest distress, shortness of breath, fatigue, fidgets and insomnia. It may also be accompanied with arrhythmia or blood pressure value between normal and high level. This heart system sub-health status can be transformed into re-lated heart system diseases with high possibility. This article made a review from aspects of theoretical literature, an-imal experiment, curative effect observation and clinical evaluation on the research progress of heart system sub-health status.

Objective: To research the effect of Wenyang Huoxue Compound Preparation on platelet receptor and signal transduction in coronary heart disease rats with yang deficiency and blood stasis of heart.Methods: The coronary heart disease rat models were established by administering high fat diet,subcutaneous injection with pituitrin and being stimulated by cold methods.Then,to observe the effect of Wenyang Huoxue Compound Preparation on platelet receptor and signal transduction.Results: Compared with model group,the concentration of plasma von Willebrand factor(vWF),the content of thromboxane B2(TXB2),the platelet aggregation rate,the molecular number of GPⅡb/Ⅲa and the content of platelet?granularmembrane protein(GMP 140) in Wenyang Huoxue Compound Preparation group decreased apparently(P

The scale and questionnaires were used to analyze the constituent ratio of symptoms at different stages. The relationship between the main syndrome and pathogenesis of coronary heart disease at different stages was analyzed by statistical methods and the medical principles analysis Thus the successive order of main symptoms and the transforming relations were ascertained. So basic pathogenesis and evolution rule of symptoms that penetrated the whole process of the disease were expounded: the dificiency of syndrome and emotinal factors were the key to the whole process of onset of coronary heart disease.

[Objective] To introduce the Chiari osteotomy combined with bone grafting shelf procedure and scew fixation for the treatment of acetabular dysplasia which was caused by all sorts of reasons.[Methods]Totally 56 patients(63 hips)with acetabular dysplasia were operated by Chiari osteotomy combined with bone grafting procedure and screw fixation from October 1982 to October 2001,the average age of the patients was 20.7 years(8~42 years).There were 7 males who didn 't have acetabular dysplasia of both hips,49 females in which 7 ones had acetabular dysplasia of both hips.The X-ray graphies before operation showed:average CE angle was 4?(-20?~ 18?),femoral head coveragement ratio was 60%(42%~75%).Sharp angle was 51?(40? ~58?),AC angle was 27?(20?~38?).All of the patients had subluxation of hip(broken Shentions line)of different degrees except two.[Results]Thirty-two patients(37 hips)had followed up results for average 45 months(6 months to 8 years).Thirty hips were obviously pain-free.The average CE angle was 44?(41? ~62?),Shape angle was 37?(30?~45?)AC angle was 12?(8? ~18?),Harris hip score was increased from 76.3(61~82)before operation to 89(76~95)after operation.Two hips had the complication of bone absorbtion after operation.[Conclusion]The Chiari osteotomy combined with bone grafting shelf procedure and stew fixation is a better procedure for the treatment of acetabular dysplasia,the main advantages of it are as following:(1)The injury during the operation is light without much blood lost,blood tranfusion is not needed.(2)It has the merits of Chiari osteotomy.(3)It can increase the femoral head coveragemean efficiently.The diameter of acetabular from anterior to posterior and the diameter form left to right can be increased.(4)It is not easy for the bone grafted to the absorbed.(5)It works in the case which can 't be absolved by only Chiari osteotomy.

Objective To explore the influence from I Ching perception of febrile disease theory to the syndrome differentiation and treatment of Viral myocarditis.Methods Documentary study.Results The febrile disease theory gained certain reference from simple ontology and motion concept in ancient Chinese philosophy.VMC was caused by disorder of five evolutive phases and six climatic factors,transition from Kan diagram to Li diagram,together with the mixture of pathogenic qi.Treatment should mainly focus on eliminating pathogen and nourishing yin to coordinate water and fire,conforming to universe rules,and smoothing Qi to reduce blockage.Conclusion The cognitive perception,pathogenesis and treatment of febrile disease theory are all deeply influenced by I Ching.Therefore,the combination of I Ching and febrile disease theory in diagnosis and treatment of VCM will improve clinical effects,as well as featuring the cultural nature of Traditional Chinese Medicine.

Objective To study the reliability and validity of clinical experts questionnaire of syndrome factors, characteristics and evolution of coronary heart disease. Methods The clinical expert questionnaire was sent to 305 clinical doctors of cardiovascular disease. The questionnaire of coronary heart disease was described through four phases data, and reliability and validity of each module and the total scale were tested. Results Cronbach's ? coefficient of the modules varies between 0.959 3～0.972 5 and higher than 0.8, the value of the scale was 0.990 3. Split-half reliability of the modules varies between 0.891 8～0.922 5, Cronbach's ? of split-half reliability of the total scale was 0.920 7. Factor analysis showed that each module was abstracted four factors and the total contribution rate was more than 50%, the result after varimax rotation was consistent with the theory. Conclusion The questionnaire can fully reflect symptoms and signs of patients with coronary heart disease, and can be used for syndrome studies of coronary heart disease.