1.Mechanism and differential diagnosis of kyphosis and the latest research progress in orthopedics
Weiqiang XIE ; Dong GONG ; Mingxuan GAO ; Ping ZHEN
China Modern Doctor 2019;57(10):165-168
The various mechanisms of kyphosis of the spine and the differential diagnosis of related diseases to guide the selection of appropriate surgical timing, correct spinal osteotomy and reasonable surgical methods. The 24 patients with kyphosis from January 2016 to January 2018 were diagnosed. All patients underwent kyphosis orthopedics, mainly spinal wedge osteotomy, to obtain orbital purpose by wedge osteotomy. The indexes of the spine form, activity, and pain were observed after operation. Of the 24 patients with kyphosis, 5 patients were treated conservatively, and the symptoms of kyphosis were effectively relieved. 19 patients underwent kyphosis orthopedic surgery, and the anterior spine and posterior closed osteotomy. The patients recovered well after surgery and were followed up regularly. The treatment of high anterior spine and posterior closed osteotomy in patients with kyphosis has accurate surgery effect. There are no complications such as pain and internal fixation during the regular follow-up.
2.Association of genetic polymorphism in phenylethanolamine-N-methyl transferase with essential hypertension in Changsha Han people.
An CHEN ; Xiaoping CHEN ; Ruizheng SHI ; Yijie GUO ; Lujia CHEN ; Mingxuan XIE ; Tianlun YANG ; Guogang ZHANG
Journal of Central South University(Medical Sciences) 2009;34(11):1120-1125
OBJECTIVE:
To investigate the association of phenylethanolamine-N-methyl transferase (PNMT) G-390A genetic polymorphism with risk of essential hypertension (EH) in Changsha Han people.
METHODS:
A case-control association study was performed in 400 patients with essential hypertension (EH) and 388 normotensive subjects. PNMT G-390A was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-FRLP).
RESULTS:
The genotype frequencies for the -390 GG, GA, and AA were 39.3%,50.0%, and 10.8%, respectively in EH patients, and were 43.6%,45.6%, and 10.8%, in normal subjects. No significant difference in either genotypic frequency (P=0.433) or allele frequency (P=0.378) of PNMT G-390A between EH patients and normals was observed. When by gender, there was significant difference in genotypic frequency (P<0.05) and allele frequency (P=0.046) of G-390A polymorphism between EH patients and normals in the male, but not in the female (P>0.05).
CONCLUSION
PNMT G-390A polymorphism is possibly associated with EH risk in male Chinese Han population in Changsha.
Adult
;
Aged
;
Base Sequence
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Case-Control Studies
;
China
;
Female
;
Genetic Predisposition to Disease
;
genetics
;
Humans
;
Hypertension
;
enzymology
;
genetics
;
Male
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Middle Aged
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Molecular Sequence Data
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Phenylethanolamine N-Methyltransferase
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genetics
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Polymorphism, Genetic
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Sex Factors
3.Depression and perceived stress among the medical residents under the
Xiaoyan ZHU ; Mingxuan XIE ; Xiongbing ZU ; Dailin ZHANG ; Rong LI
Journal of Central South University(Medical Sciences) 2020;45(12):1450-1456
OBJECTIVES:
It is an important reform for medical education in China to combine professional postgraduate training with standardized resident training. This study aims to evaluate the depression and perceived stress in postgraduate students of clinical medicine and residents from society and to determine the relation between depression and perceived stress in medical residents.
METHODS:
Chinese Perceived Stress Scale (CPSS) and Self-Rating Depression Scale (SDS) were applied to 330 residents (including 235 postgraduate students of clinical medicine and 95 residents from society) from a Class-A Grade-3 genernal hospital in Hunan Province to evaluate and compare the depression and perceived stress in postgraduate students of clinical medicine and residents from society. Pearson correlation analysis was performed to assess the association between depression and perceived stress. Stress resources between 2 groups of residents were observed and compared.
RESULTS:
Of the 235 postgraduate students of clinical medicine, 148 (63.0%) showed depression and 162 (68.9%) showed elevated perceived stress. Main stress resources were academic pressure, scientific research pressure, and employment pressure. Of the 95 residents from society, 52 (54.7%) showed depression and 58 (61.1%) showed elevated perceived stress. Main stress resources were economic stress, employment pressure, and academic pressure. The scores of CPSS and SDS were significantly higher in postgraduate students of clinical medicine than those in residents from society (
CONCLUSIONS
Residents (including postgraduate students of clinical medicine and residents from society) possess depression and elevated perceived stress with positive correlation. The postgraduate students of clinical medicine show higher level of depression and perceived stress than the residents from society under the "unified double-track" training system.
China/epidemiology*
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Depression/epidemiology*
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Humans
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Internship and Residency
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Students, Medical
4.Internal fixation of lateral and medial borders for displaced scapular body fractures via minimally invasive approach:results of 23 cases
Mingxuan GAO ; Dejun NIE ; Yanfeng CHANG ; Weiqiang XIE ; Yue WANG ; Xingyu PU ; Wei ZHANG ; Wenyuan LUO
Journal of Zhejiang University. Medical sciences 2019;48(6):651-656
OBJECTIVE: To evaluate the efficacy of internal fixation of lateral and medial borders for displaced scapular body fractures via the minimally invasive approach. METHODS: The internal fixation of lateral and medial borders via minimally invasive approach was applied in surgical treatment of 23 patients with scapular body comminuted fractures from January 2014 to June 2018. The lateral approach was made straightly orienting over the lateral border of scapula. The dissection was taken down to the deltoid fascia. The deltoid was retracted cephalically, revealing the external rotators. Blunt dissection was used down to the lateral border between infraspinatus and teres minor, exposing the fracture site. The medial incision was done along the medial border of the scapula over site of the fracture. Dissections were taken down to the fascia and the periosteum. A subperiosteal dissection was then performed to elevate the infraspinatus to the degree necessary to visualize the fracture. The medial and lateral borders of scapula body were fixed with plates and screws in a frame-like way. RESULTS One patient developed the delayed healing of the incisions due to liquefactive fat necrosis. The other 22 patients showed no complications of the incisions. The glenopolar angle (GPA) of fractured scapula was increased from preoperative (25±12) degrees to postoperative (41±5) degrees (P<0.01). The healing time of fractures healed was 3-8 months, with an average time of (4.4±1.3) months. CONCLUSIONS The lateral-medial combined fixation through minimally invasive surgical approach for the scapula body fractures allows visualization of fracture reduction without extensive muscular or subcutaneous flaps, and is associated with successful fracture healing and high functional scores of the shoulder.