Objective To study the metastasis rule and influence factors of cervical central group (Ⅵ region) lymph node in patients with papillary thyroid microcarcinoma.Methods The clinical data of 195 patients with papillary thyroid microcarcinoma were analyzed retrospectively.All patients received bilateral thyroidectomy and bilateral cervical central group lymph node dissection.Results All patients died without surgery and hospitalization,the incidence of postoperative complications was 2.1％ (4/195).The total incidence of cervical central group lymph node metastasis was 35.4％ (69/195).Factors relating to cervical central group lymph node metastasis rate were:age (OR =0.924),gender (OR =0.213),the number of foci (OR =2.208) and the sum of the tumor diameters (OR =2.106).Conclusions Patients with papillary thyroid microcarcinoma may suffer from lymph node metastasis of the cervical central group,and lymph node metastasis rate increases significantly in young or male patients,and when the lesions are multifocal or the sum of the tumor diameter ＞ 0.5 cm.

Objective To compare the effects of ureteroscopic lithotripsy (URL), minimally invasive percutaneous nephrolithotomy ( MPCNL) , retroperitoneal laparoscopic ureterolithotomy ( RLU) and open ureterolithotomy (UL) for the treatment of complex upper ureteral calculi. Methods The data of 281 patients with complex upper ureteral calculi from January 2005 to January 2013 were retrospectively reviewed. 48 patients of them received treatment of URL, 113 patients received MPCNL, 67 patients received RLU and other 53 patients received UL. Results Success rates of treatment at the first time were:URL 62.5% (30/48), MPCNL 92.9%(105/113),RLU 100%(67/67) and UL 100%(53/53) . The mean blood losses during the operation were:URL (9.2 ± 1.4) mL,MPCNL (72.5 ± 5.8) mL,RLU (43.1 ± 8.5) mL and UL (100.5 ± 9.2) mL. The average operation time of URL group was shorter than three other groups, and the difference was statistically significant (P< 0.05) . The average hospital stay of URL group was also shorter than three other groups ( < 0.05) . The difference was not statistically significant in complications among four groups after operation ( >0.05) . Conclusion Clinical characteristics of patients and individual require ment should be considered comprehensively before an individual treatment choice is made for the treatment of complex upper ureteral calculi.

Objective In this study ,to explore the relationship between the renal blood flow PI ,and the AKI was caused by CPB .Methods 14 cases with heart disease were accepted .The renal aorta and renal segmental artery PI of all cases were monitored by the CDFI at the preoperative and postoperative 1 h ,2 h ,4 h ,8 h ,16 h ,24 h .The renal blood urea nitrogen (Urea) ,uric acid (UA) ,creatinine (Crea) ,were detected at the same time .All datas for statistical analysis .Results The renal aorta PI was higher at the postoperative 1 h ,2 h ,4 h ,8 h ,16 h than that at the preoperative .The renal segmental artery PI was higher at the postoperative 1 h ,2 h ,4 h ,16 h than that at the preoperative .The renal blood flow PI was positively correlated with Urea ,UA and Crea .Conclu-sion The renal aorta ,renal segmental artery PI was positively correlated with Urea ,UA and Crea after CPB .The PI may be seen as an evaluation index to assess AKI after CPB .

Objective:This study aimed to investigate the relationships between anthropometric parameters and carotid elasticity by real-time vascular quantification stiffness technique (R-VQS), and to identify the predictive value of anthropometric parameters for cardiovascular disease risk.Methods:A total of 563 adults were recruited for this study and were divided into two groups by gender. The anthropometric indices [body mass index (BMI), waist circumference (WC), a body shape index (ABSI), body round index (BRI), and visceral adiposity index (VAI)] were calculated. R-VQS technique was used to assess the parameters of carotid elasticity: pulse wave velocity (PWV). The correlations between the anthropometric indices and PWV were analyzed. Linear regression was used to analyze the predictive factors of PWV.Results:⑴ The BMI, WC, ABSI, BRI, VAI and PWV were higher in men than those in women ( P<0.05); ⑵ In men and women, all the anthropometric parameters positively correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TG), and negatively correlated with high-density lipoprotein (HDL) ( P<0.05); ⑶ diabetes mellitus (DM) and hypertension history were predictors of PWV in men ( β=0.110, 0.101, respectively, P<0.05); DM, hypertension history and smoking status were predictors of PWV in women ( β=0.061, 0.095, 0.067, respectively, P<0.05); ⑷ After adjusting for diabetes, hypertension and smoking, ABSI and VAI were predictors of PWV in men ( β=0.078, 0.068, P<0.05); BMI, WC, ABSI, BRI and VAI were predictive factors of carotid PWV in women ( β=0.131, 0.123, 0.204, 0.153, 0.196, P<0.05). Conclusions:Among the anthropometric indexes, ABSI and VAI have good correlations with carotid elasticity in wen and women, represented by PWV. These results suggest that ABSI and VAI may be convenient, highly cost-effective and simple parameters for obesity and are associated with cardiovascular disease (CVD) risk in clinical practice. R-VQS is a convenient, real-time and rapid technique for the early assessment of the carotid elasticity.

Interference with quorum sensing(QS)represents an antivirulence strategy with a significant promise for the treatment of bacterial infections and a new approach to restoring antibiotic tolerance.Over the past two decades,a novel series of studies have reported that quorum quenching approaches and the discovery of quorum sensing inhibitors(QSIs)have a strong impact on the discovery of anti-infective drugs against various types of bacteria.The discovery of QSI was demonstrated to be an appropriate strategy to expand the anti-infective therapeutic approaches to complement classical antibiotics and antimicrobial agents.For the discovery of QSIs,diverse approaches exist and develop in-step with the scale of screening as well as specific QS systems.This review highlights the latest findings in strategies and methodologies for QSI screening,involving activity-based screening with bioassays,chemical methods to seek bacterial QS pathways for QSI discovery,virtual screening for QSI screening,and other potential tools for interpreting QS signaling,which are innovative routes for future efforts to discover additional QSIs to combat bacterial infections.

In March 2019, a patient with advanced prostate cancer was diagnosed in Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, and the disease progressed to the stage of mCRPC after traditional endocrinotherapy. Serious adverse event occurred after 1 month of treatment with abiraterone, which result in drug withdrawal, and replaced therapy by enzalutamide, the effect was good.