BACKGROUND: At present, there are few reports on systematic evaluation/meta reevaluation of acupuncture for lumbar disc herniation through radar plot in and outside China, which are insufficient to provide references for clinical decision-making. OBJECTIVE: To evaluate systematic reviews/meta-analysis of acupuncture in the treatment of lumbar disc herniation qualitatively and quantitatively by using the multiple evaluation thinking of radar plot so as to provide visual and scientific decision-making means for clinical practice and medical research. METHODS: Computer retrieval was performed in eight Chinese and English databases to collect data of systematic reviews/meta-analysis of acupuncture in the treatment of lumbar disc herniation. The retrieval time was from database establishment to August 2019. Moreover, the multiple evaluations were carried out from six dimensions, including publiscation year, research type, A Measurement Tool to Assess systematic Reviews (AMSTAR) 2 methodological quality score, Preferred Reporting Items for Systematic Reviews and Meta-Analys is (PRISMA) quality score, homogeneous, and publication bias risk so as to calculate average rank score. The quality of all included outcome indicators was graded using GRADE evidence quality assessment tools. Excel 2013 was used to draw and optimize the radar plot for intuitive analysis. RESULTS AND CONCLUSION: A total of 11 qualified studies were included. According to data extraction, the radar plot showed that the included 11 articles scored 6.95 in the quality of the average rank. Some issues were found such as item registration, structured abstract, search strategy, exclusion literature list, and publication bias. Grading of recommendations assessment, development and evaluation (GRADE) evidence quality scores are low, with very low quality as the main reason. The literature quality of systematic reviews/meta-analysis of acupuncture in the treatment of lumbar disc herniation was not high. The methodological quality and reporting quality should be improved and continuously strengthened in order to further improve the quality of literature. As a visual and effective method of graphic evaluation, the radar plot can show the distribution of required data intuitively and concisely.

OBJECTIVE： To evaluate the literature quality of systematic reviews/Meta-analysis of oral administration of traditional Chinese medicine （TCM） in the treatment of lumbar disc herniation （LDH） using radar plot， and to provide scientific and effective evidence for clinical use of medicine. METHODS： Retrieving CNKI， VIP， Wanfang database， CBM， PubMed， Cochrane library and Embase during the establishement of database to Oct. 1st， 2018， the literatures about systematic reviews/Meta-analysis of oral administration of TCM in the treatment of LDH were collected. After data extraction of literatures met inclusion criteria， the quality literatures were evaluated from 6 aspects of radar plot （year of publication， design type， AMSTAR methodological quality evaluation， PRISMA reprot quality evaluation， homogeneous， publication bias risk）. The average score of rank number was calculated. Moreover， Excel 2010， Adobe Illustrator CC and other software were used to draw and optimize the radar plot. RESULTS： A total of 6 qualified literatures were included； average score of rank number of 6 aspects were 3.83， 4.67， 3.83， 3.67， 6.00， 4.67， scoring 4.56 in average. Multivariate evaluation of radar plot showed that 2 studies had higher qualities and only 1 study had lower qualities relatively. However， problems could be found such as information selection bias， inclusion and exclusion criteria， publication situation， limitations， project registration. CONCLUSIONS： The literature quality of systematic review/Meta-analysis of oral administration of TCM in the treatment of LDH need to be improved， starting with strengthening methodological quality and reporting quality. Radar plot is a visual and effective method of graphic evaluation， which is worth popularizing and applying in the future.

Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surface-enhanced Raman scattering (SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications. In this review we elaborate on recent progress in design strategies with emphasis on material properties, modifying factors, and structural parameters.