1.The Influence of Family History on Stage and Survival of Gastric Cancer According to the
Hee Jin KIM ; Mingu KWON ; Nayoung KIM ; Jae Bong LEE ; Sungho WON
Gut and Liver 2020;14(1):79-88
Background/Aims: The survival rate of gastric cancer (GC) is known to be higher in patients with a family history (FH) of GC. There is an association between a polymorphism in the transforming growth factor-β1 (Methods: Results: The proportion of stage I–II GCs was significantly higher in patients with a FH than in those without a FH of GC (83.8 vs 74.9%, p=0.005). The association between a FH of GC and stage I–II GC was not significant in subgroups divided based on the Conclusions Patient with a FH of GC had lower cancer stage (I–II) at diagnosis than those without a FH of GC, but there was no significant difference in overall survival between the patients with and without a FH of GC. A FH did not influence the tumor stage or overall survival in patients stratified by the presence of the
2.A Case of Community-acquired Bacteremic Empyema Caused by Kocuria kristinae.
Ka Young KIM ; Jae Hyun CHO ; Chang Min YU ; Kyung Jin LEE ; Jae Min LEE ; Seokyoung KOH ; Mingu KWON ; Dasol JEONG
Infection and Chemotherapy 2018;50(2):144-148
Kocuria kristinae, part of the normal flora of the skin and oral mucosa, is seldom reported as a human pathogen; infection is mostly associated with immunocompromised patients in healthcare facilities. Here, we describe the first case of bacteremic empyema caused by K. kristinae acquired from the community. K. kristinae was isolated from pleural effusion and two sets of peripheral blood samples drawn from two different sites. The empyema resolved after the insertion of a chest tube and intravenous administration of piperacillin-tazobactam and levofloxacin.
Administration, Intravenous
;
Bacteremia
;
Chest Tubes
;
Community-Acquired Infections
;
Delivery of Health Care
;
Empyema*
;
Humans
;
Immunocompromised Host
;
Levofloxacin
;
Mouth Mucosa
;
Pleural Effusion
;
Skin
3.A Case of Community-acquired Bacteremic Empyema Caused by Kocuria kristinae.
Ka Young KIM ; Jae Hyun CHO ; Chang Min YU ; Kyung Jin LEE ; Jae Min LEE ; Seokyoung KOH ; Mingu KWON ; Dasol JEONG
Infection and Chemotherapy 2018;50(2):144-148
Kocuria kristinae, part of the normal flora of the skin and oral mucosa, is seldom reported as a human pathogen; infection is mostly associated with immunocompromised patients in healthcare facilities. Here, we describe the first case of bacteremic empyema caused by K. kristinae acquired from the community. K. kristinae was isolated from pleural effusion and two sets of peripheral blood samples drawn from two different sites. The empyema resolved after the insertion of a chest tube and intravenous administration of piperacillin-tazobactam and levofloxacin.
Administration, Intravenous
;
Bacteremia
;
Chest Tubes
;
Community-Acquired Infections
;
Delivery of Health Care
;
Empyema*
;
Humans
;
Immunocompromised Host
;
Levofloxacin
;
Mouth Mucosa
;
Pleural Effusion
;
Skin
4.Efficacy of and Resistance to Rifaximin-based Quadruple Therapy in Helicobacter pylori Eradication
Hyun Soo KIM ; Hyuk YOON ; Dong Woo SHIN ; Dong Jun OH ; Mingu KWON ; Yoon Jin CHOI ; Cheol Min SHIN ; Young Soo PARK ; Nayoung KIM ; Dong Ho LEE
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2020;20(3):218-224
Background/Aims:
The treatment options for Helicobacter pylori (H. pylori) infection are in a state of flux: traditional triple therapies have started to fail, and new treatments are unable to achieve optimal eradication rates. Rifaximin and rifabutin are new antibiotics. The aim of this study was to evaluate the efficacy and safety of adding rifaximin to the standard triple regimen and of a rifabutin-based triple regimen as a rescue therapy for H. pylori eradication.
Materials and Methods:
We enrolled 27 H. pylori-positive patients who were treated with a proton pump inhibitor, amoxicillin, clarithromycin, and rifaximin for 14 days. H. pylori eradication was assessed by a 13C-urea breath test performed 4 weeks after therapy completion. The efficacy of the therapy was based on intention-to-treat (ITT) and per-protocol (PP) analysis. We also investigated the resistance rate, compliance, and side effects associated with rifaximin therapy. Minimal inhibitory concentrations and resistance to rifabutin were evaluated using the agar dilution method.
Results:
Of the 27 patients, 22 completed the treatment protocol with 100% compliance; five patients withdrew. The ITT and PP eradication rates for the rifaximin-containing quadruple therapy were 70.4% (19/27) and 86.3% (19/22), respectively. Adverse events were observed in five of 22 patients (22.7%). The resistance rates to rifaximin and rifabutin were 66.7% (2/3) and 0% (0/3), respectively.
Conclusions
The findings of this study show the limitations of rifaximin-based quadruple therapy and suggest the benefits of a rifabutin-based rescue regimen in South Korea.
5.Case of Ischemic Colitis Associated with Pseudoephedrine.
Su Hyun YUN ; Seong O SUH ; Chae A PARK ; Bo Yoon CHOI ; Mingu KWON ; Min Ho JANG ; Jin Wuk GWAK ; Dasol JEONG ; Dong Hwan SHIN ; Sang Jae KWON ; Dawoori CHOI ; Je Seung LEE
Journal of the Korean Society of Emergency Medicine 2016;27(1):134-138
Ischemic colitis is the consequence of a sudden reduction in colon blood supply, which in turn results in ischemic injury. The splenic flexure and rectosigmoid junction are the areas most often affected. Ischemic colitis occurs with greater frequency in the elderly and is caused by various medications and procedures. Pseudoephedrine acts as a vasoconstrictor directly affecting adrenal receptors of nasal mucous membrane. Pseudoephedrine occasionally causes vascular insufficiency due to intense vasoconstriction, even at standard doses. Ischemic colitis associated with pseudoephedrine has been reported in other countries,, but it has never been reported in Korea. In this paper, we describe 3 cases of ischemic colitis that occurred after taking pseudoephedrine for nasal congestion.
Aged
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Colitis, Ischemic*
;
Colon
;
Colon, Transverse
;
Estrogens, Conjugated (USP)
;
Gastrointestinal Hemorrhage
;
Humans
;
Korea
;
Mucous Membrane
;
Pseudoephedrine*
;
Vasoconstriction