Objective To compare the analgesia effects of Oxycodone hydrochloride with Sufentanil in laparoscopic cholecystectomy (LC) anesthesia induction. Method Sixty patients scheduled for elective LC, ASAⅠ or Ⅱ , were randomly divided into two groups (30 in each): Oxycodone group (group O) and Sufentanil group (Group S). Induction of anesthesia: group O: Propofol 1.0 ~ 2.0 mg/kg, Oxycodone 0.3 mg/kg, Vecuronium 0.1 mg/kg. Group S: Propofol 1.0 ~ 2.0 mg/kg, Sufentanil 0.3 μg/kg and Vecuronium 0.1 mg/kg. The value of HR, SBP, DBP of the two groups were recorded in the operation room (T0), after anesthesia induction (T1), 1 min after insertion laryngeal mask (T2), the instant of pneumoperitoneum establishment (T3), separation of the gallbladder (T4), the time of wake up (T5), leave the recovery room (T6). The numeric pain rating scale (NRS) were recorded at T4, T5, 4 hours later (T7), 8 hours later (T8), one day later (T9). Then recorded the wake time and additional analgetic cases. Recorded the adverse reactions. Results The average HR, SBP and DBP fluctuations in the two groups were not more than 20.0 % of the basal values. There was no significant difference in wake time between the two groups. There were 11 cases of patients, the NRS>4, in Sufentanil group requires additional analgesics after they wake up, more than Oxycodone group (P = 0.040). The NRS score was lower in Oxycodone group than group S in T5, T7, T8, T9, but they had no statistically significant difference. There was no significant difference in adverse reactions between the two groups. Conclusion 0.3 mg/kg Oxycodone and 0.3 μg/kg Sufentanil for anesthesia induction of LC, the anesthesia and analgesia effect is good, can satisfy the clinical anesthesia and postoperative analgesic requirements. The analgesic effect of 0.3 mg/kg Oxycodone may be comparable or better than 0.3 μg/kg Sufentanil.

Objective To analyze the clinical value of 1. 5T dynamic enhanced MRI in the differential diagnosis of prostate cancer. Methods A total of 298 patients with prostate disease admitted to Zhejiang Quhua Hospital from January 2017 to December 2017 were enrolled. All subjects underwent MRI(including T2WI,DWI, DCE),and the results of all subjects were observed. The pathological biopsy was used as the gold standard for diagnosis. The possibility of prostate cancer was evaluated. Results Among the 298 patients with prostate disease,there were 136 cases of prostate cancer,including 84 cases of peripheral prostate cancer,the detection rates of T2WI,DWI and DCE were all 100. 00％,52 cases of central gland prostate cancer,the detection rates of T2WI,DWI and DCE were 100. 00％,98. 08％,and 98. 08％,respectively. Among 298 patients with prostate disease,there were 162 cases of pre-existing adenitis,including 64 cases of peripheral prostatitis. The detection rates of T2WI,DWI and DCE were 98. 44％,100. 00％,96. 88％,respectively,98 cases of central glandular gland inflammation,the detection rates of T2WI,DWI,DCE were 97. 96％,100. 00％,98. 98％,respectively. Conclusion 1. 5T dynamic enhanced MRI can correctly detect prostate diseases,especially prostate cancer.