1.The research status and prospects of microRNA-glial regulatory network in radiation-induced brain injury
Mingqian OU ; Furong SUN ; Weihao FAN ; Lili CUI ; Minhua LI ; Meijun LIN ; Yangsheng YU ; Shiyun LIANG ; Haihong ZHOU
Chinese Journal of Radiological Medicine and Protection 2020;40(7):564-569
Radiation-induced brain injury (RBI) is the most serious complication of head and neck tumor after radiotherapy. The pathogenesis of RBI is complicated, and the clinical course is irreversible, while no effective treatment available. The activation of glial cells is one of the main theories of RBI, and the prevention and treatment of RBI by targeting glial cells is the focus of current research. As a post-transcriptional regulatory factor, microRNA (miRNA) has been confirmed to be involved in regulatingglial cell radiosensitivity, inflammation type transformation, autophagy, exosomatic, long non-coding RNA (lncRNA), circular RNA (circRNA) and other related pathways, thereby mediating the occurrence and development of cascade reaction of inflammatory injury and neurological function repair of central nervous system (CNS) disease. Therefore, the establishment of miRNA - glial regulatory network may provide a new strategy for the prevention and treatment of RBI.
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