Objective To explore the clinical outcome of individuals with Clinical High Risk (CHR) for psychosis and its relationship with Theory of Mind (ToM) function.Methods The Structured Interview for Prodromal Symptoms/Scale of Prodromal Syndromes (SIPS/SOPS) was applied to assess prodromal psychosis.The Reading the mind in the Eyes and faux pas Task were conducted to assess the function of Theory of Mind among the individuals of clinical high risk of psychosis.All participants had completed the 2-year follow-up.Conversion was determined using the criteria of presence of psychotic symptoms (POPS).According to the outcome,CHR individuals were divided into conversion group (n=20) and no-conversion group (n=50).The baseline clinical symptom characteristics and Theory of Mind were compared between groups.Results There was no significant difference in clinical symptom characteristics among individuals with CHR (P＞0.05).In the faux pas text,there were significant differences in Faux Pas Detection (P=0.01),Faux Pas Understanding (P=0.01) and Faux Pas Total (P=0.02) but not in control stories and the Reading the Mind in the Eyes Test between convertors and non-convertors (P＞0.05).Conclusion The ToM disability in clinical high risk population increases risk for conversion to psychosis.

As one of special groups in social groups,vagrant psychiatric patients have uniqueness.There are many ethical issues in their diagnosis and treatment,such as voluntary principles and involuntary medical treatment,protective constraints,patient's privacy protection,personalized treatment,fairness and so on.Therefore,to protect the fights and interests of psychiatric patients,it should strictly follow the standard of involuntary hospitalization and four principles of medical ethics when they are admitted to hospital;it should give protective constraints and make the diagnosis of mental disorder when they exist impulses and negative risks involved themselves or others.Meanwhile,it should give psychological counseling,take minimum limit to patient as principle,develop personalized treatment plan,provide humanity service,pay attention to the protection of privacy rights and promote early recovery of patient.