OBJECTIVE:To study the protective effects of Mongolian medicine Lomatogonium rotatum water extract against acute liver injury in mice caused by D-GlaN and CCl4. METHODS:60 mice were randomly divided into normal group(normal sa-line),D-GlaN model group(normal saline),positive control group(Kuihua hugan tablet,0.56 g/kg)and L. rotatum water extract high-dose,medium-dose and low-dose groups [3,1.5,0.75 g(crude drug)/kg] 10 rats in each group. They were given relevant medicine intragastrically once a day for consecutive 23 days. 30 min after last administration,those group were given D-GlaN ip to induce acute liver injury model except normal group. The activity of AST,ALT,ALP,and acetylcholinesterase(CHE)content in serum were detected,and liver index was calculated. Liver histopathology was observed and scored. Other 60 mice were selected, and then grouped,given medicine and detected in lab index with same method with above group,except for modeling method(ig, 0.1% CCl4). RESULTS:Compared with normal group,necrosis or degeneration of liver cells were obvious in 2 model groups, pathological score,the activity of AST,ALT and ALP increased while CHE content decreased;liver index of D-GlaN model group increased while that of CCl4 model group decreased (P<0.05). Compared with D-GlaN model group,the activity of AST,ALT and ALP and liver index decreased in L. rotatum water extract groups,while CHE content increased(P<0.05);pathological mor-phology had been improved,and pathological score decreased. Compared with CCl4 model group,ALT activity decreased in L. rota-tum water extract low-dose group,while CHE content and liver index increased;CHE content of L. rotatum water extract medi-um-dose group decreased,while liver index increased;the activity of AST,ALT and ALP decreased in L. rotatum water extract high-dose group,while CHE content increased(P<0.05). Pathological morphology of L. rotatum water extract groups had been im-proved to certain extent,and pathological score decreased. CONCLUSIONS:L. rotatum water extract could protect acute liver inju-ry in mice induced by D-GlaN and CCl4.

Objective To investigate the prevalence of workplace violence and explore the relationship between workplace violence and emotional intelligence among psychiatric nurses Methods Totally 453 nurses were enrolled from five psychiatric hospitals via regional stratification and clustersampling in Shandong province. The workplace violence frequency scale, emotional intelligence scale were administered. Results The average workplace violence score among psychiatric nurses was (6.64 ± 3.56) points, while the emotional intelligence average score was (3.79 ± 0.37) points. The each dimensions of emotional intelligence were negatively correlated with workplace violence and types of workplace violence among psychiatric nurses(r=-0.496--0.214, P<0.01). Results of hierarchical liner regression showed that self-emotion management, type of ward, emotional awareness, hospital degree, gender could negatively predict workplace violence of psychiatric nurses (R2=0.333,F=44.636, P=0.000). Conclusions Workplace violence is prevalent among psychiatric nurses, and emotional intelligence might have influence on workplace violence.