1.Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER
Keqi WANG ; Yongyan CHEN ; Shuo GAO ; Maosi WANG ; Mengmeng GE ; Qian YANG ; Mingkai LIAO ; Lin XU ; Junjie CHEN ; Zhiping ZENG ; Haifeng CHEN ; Xiao-Kun ZHANG ; Ting LIN ; Hu ZHOU
Acta Pharmaceutica Sinica B 2021;11(2):442-455
Although different types of drugs are available for postmenopausal osteoporosis, the limitations of the current therapies including drug resistances and adverse effects require identification of novel anti-osteoporosis agents. Here, we defined that norlichexanthone (NOR), a natural product, is a ligand of estrogen receptor-alpha (ER
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