Objective To investigate the effecof Iκkinases(IKK) inhibitoIKK16 on the proliferation and apoptosiof hu-man glioblastomcell line U87 and itpossible mechanism .MethodHuman glioblastomcell line U87 wacultured in vitro and divided into 4 group:blank group(withouintervention treatmen) ,control group(1% dimethyl sulfoxide) ,low dose IKK group (70 nmol/L IKK16) and high dose IKK group(200 nmol/L IKK16) .The Mtassay waused to detecthe effecof IKK16 on the proliferation of U87 cellathe low concentration and the high concentration .Western blowaused to investigate the effecof IKK16 on the expression of p65 ,cyclinD1 ,caspase-3 and bcl-2 .ResultThe U87 proliferation rate had no statistical difference be-tween the blank group and the control group(P＞0 .05) .Compared with the control group ,IKK16 could significantly suppresthe proliferation of U87 cell(P＜0 .05) .Athe same time ,IKK16 significantly reduced the expression of p65 ,CyclinD1 and Bcl-2 ,and increased the expression of caspase-3(P＜0 .05) with dose-dependenmanne.Conclusion IKK16 could suppresthe proliferation of human glioblastomcell line U87 and promote the apoptosi.

Objective To analyze the curative effect of super-early keyhole surgery in treatment of hypertensive cerebral hemorrhage. Methods Clinical data of patients with hypertensive cerebral hemorrhage who received treatment in our hospital from April 2010 to October 2012 were retrospectively analyzed. Patients were divided into the observation group ( keyhole surgery group) and the control group ( routine group) by different therapeutic methods. The operation time, rate of hematoma clearance, postoperative complications, and recovery of neu-ral function of the two groups were compared. Results The observation group had a shorter operation time than the control group, and the difference was statistically significant(P<0. 001). There was no singnificant difference between the two groups in rate of hematoma clear-ance at the time of tube drawing(P>0. 05). The observation group had less postoperative complications than the control group, and the difference was statistically significant(P<0. 05). The observation group had a lower rate of metabolic disorders than the control group with a statistically significant difference(P<0. 05). Patients of the observation group had a higher scores of SSS than patients of the control group 28 days after operation, and the difference was statistically significant(P<0. 05). 6 months after operation, the observation group had a bet-ter ADL than the control group, and the difference was statistically significant(P<0. 05). Conclusion Super-early keyhole surgery which has less intraoperative injury, postoperative complication, and metabolic disorders, can achieve a better effect than routine operation. And it is of better neural functional recovery.

Objective:To investigate the effect of dynamic traction technique on postoperative complications, stress response and neurological function recovery in patients with petroclival meningioma undergoing microscopic resection.Methods:The clinical data of 80 patients with petroclival meningioma in Huanggang Central Hospital of Hubei Province from January 2017 to December 2019 were retrospectively analyzed. Among them, 38 cases were treated with automatic retractor technique (automatic traction group), and 42 cases were treated with dynamic traction technique (dynamic traction group). The operation time, postoperative hospital stay, postoperative complications of brain traction injury and the degree of Simpson tumor resection were compared between 2 groups. The levels of serum stress indexes before and after operation were detected, including C-reactive protein (CRP), interleukin-6 (IL-6) and white blood cell count (WBC). Karnofsky performance status (KPS) score was performed 6 months after operation, and the recovery rate of neurological function (KPS score≥80) and recurrence rate were counted.Results:There were no significant differences in operation time, postoperative hospital stay and the degree of Simpson tumor resection between 2 groups ( P>0.05). The incidence of postoperative complications of brain traction injury in dynamic traction group was significantly lower than that in automatic traction group: 4.76% (2/42) vs. 21.05% (8/38), the recovery rate of neurological function 6 months after operation was significantly higher than that in automatic traction group: 83.33% (35/42) vs. 39.47% (15/38), and there were statistical differences ( P<0.05 or<0.01). The serum CRP, IL-6 and WBC in dynamic traction group were significantly lower than those in automatic traction group: (24.11±5.86) mg/L vs. (28.42±5.94) mg/L, (10.52±2.29) pg/L vs. (12.45±2.46) pg/L and (9.24±2.43) ×10 9/L vs. (10.84±2.38) ×10 9/L, and there were statistical differences ( P<0.01). No recurrence was found in both groups. Conclusions:Dynamic traction technique in microscopic resection of petroclival meningioma can effectively reduce the postoperative complications of brain traction injury, reduce surgical stress, promote the recovery of neurological function, and improve the prognosis of patients.

Objective To evaluate the clinical efficacy of antibiotic -impregnated shunt catheters in hydrocephalus shunt. Methods A retrospective analysis of clinical data from patients with hydrocephalus shunt surgery in our hospital during the period from May 2011 to August 2016. Based on the types of catheters, patients were divided into common conduit (not AISCs group) and antibiotics infiltrating pipe groups (AISCs group). All patients were followed up for 6 months after shunt surgery. The diversion and infection was recorded. Results The data of 193 patients with hydrocephalus shunt were analyzed, including 124 cases of non-AISCs group and 69 cases of AISCs group. Compared with non-AISCs group,the incidence of postoperative infection of AISCs was significantly decreased(P<0.05). There was no significant difference in the incidence of shunt and reoperation between the two groups (P>0.05). In addition, there was no significant difference in the rupture, displacement and exposure of the two groups (P>0.05).Conclusion ASICs can effectively reduce the incidence of hydrocephalus shunt infection.