The article analyzes the TCM etiology, pathogenesis of geriatrics and pathological basis and clinical treatment medication of several common geriatrics. Chinese herb formula with function of invigorating the kidney and promoting blood circulation has the preferable curative effect on geriatrics, so we consider that kidney defi ciency and blood stasis is the main pathogenesis of geriatrics. Invigorating the kidney and promoting blood circulation is an important treatment of geriatrics, and should be followed through the whole therapeutic process.

Stomach-qi refers to, in a broad sense, the vital qi of human body, i.e. postnatal vigorous qi and, in a narrow sense, the physiological function of spleen and stomach. Digestive function of spleen and stomach and nutrition get from diet play a key role in keeping and maintaining life and health. Human rely on the qi of food and water they take in, and qi of spleen and stomach transports and transforms the food and water, so we say, “Stomach-qi is the root of human body”. Pathologically, the stomach qi strong or declin is one of the key factors results in diseases. One will be healthy or seldom affected by disease if his or her stomach qi is not damaged; even affected by severe disease, with undamaged stomach-qi and good appetite, one will have a favorable turn. On the contrary, once the stomach-qi is hurt, one will be easily affected by evils or state of the illness will aggravate. So, “If one wants to observe the state of an illness, he or she must observe stomach-qi first; if one wants to treat a patient, he or she must consider the stomach-qi. There would be no worries, if stomach-qi is fine.” Principles for protecting stomach-qi is to treat and regulate the diseases of spleen and stomach in time and to take care of spleen and stomach when one is treating disease of other viscera.

Objective: To explore the compatibility and application methods of clinical formulas.Methods: In the guidance of monarch,minister,assistant and guide theory, the constructions of prescription were divided into principal agents and lesser agents;500 prescriptions were from 1000 set prescriptions and empirical formulas recorded in pharmacology of traditional Chinese medical formulae teaching material and well-chosen efficacy nostrum written by national lever famous veteran teran doctors of TCM.Then they were analyzed to study the constituting formats of(clinical) formulas and the derivation methods of set prescriptions in clinical application.Results: Through analysis,we found the constituting formats of formulas in terms of single taste single group having principal agents but lesser agents(12.3%),multitude groups having principal agents but lesser agents(13.7%),single taste or single group principal agents with one group lesser agents(14.4%),multitude groups principal agents with one group lesser agents(17.7%),single taste or single group principal agents with multitude groups lesser agents(18.3%) and multitude groups principal agents with multitude groups lesser agents(23.6%) et al.From the 500 randomly extracted prescriptions,among 68.4% prescriptions were present derivation relationship,that is,for adapting new pathogenesis conditions,through methods in terms of replacing principal agents(10.2%),mild recipe lowering to lesser agents(17.0%),two formulas to put together(14.3%),expanding principal agents(16.4%),changing lesser agents(18.7%),principal agents pero-replacing(10.2%) and others(13.2%),changed constituted relation of principal agents or lesser agents,so to generate several formulas possessing new effect characteristics.Conclusion: The(divide) of principal agents and lesser agents has a universal applicability in analyzing the constitutions of formulas;the clinical application and derivation methods of set prescriptions revealed by this method have guide effect to initial(experiencing) clinical worker.

[Objective]On the origin and development of stroke research and interpretation. [Methods]Reading from pre-Qin period to the Ming and Qing dynasties in the ancient literature related to stroke the literature, according to the treatment of disease, etiology, pathogenesis, therapeutic principle, prevention and curing of Chinese medical induction, summary, combining the origin of stroke, analysis of pathogenesis and therapeutic principle of stroke, and it is filtered and classified the ancient literature and research, summarizes the extraction.[Methods]Reading and analyzing ancient documents related to the stroke.[Results]The termstrokeand theoretical source inNei Jing, the treatment based on syndrome differentiation is initiated Treatise on Febrile and Miscellaneous Diseases.Jin and Yuan dynasties developed stroke theory;modern perfect stroke syndrome differentiation system. Previously, during the Tang and Song dynasties, it is mainly based on the theories of vital Qi deficiency,pathogenic wind into the argument, treatment of strengthening the body and removal of scattered wind. After the Jin Yuan dynasties, they are internal injury based, wind from the endogenous theories. the treatment is mainly focused on internal injuries. [Conclusion]That ancient physicians paid attention to the etiology and treatment of stroke more, keeping in good health and prevention mentioned less, so we should pay attention to the prevention and recovery.

Objective To discuss the clinical effect of Xipayinguyinye on oral bacteria in vitro and gingivitis in vivo.Methods Took the method of agar dilution to measure the minimum inhibitory concentration (MIC) of Xipayinguyinye on Porphyromonas gingivalis ( P.gingivalis),Prevotella intermedia ( P.intermedia ) and Fusobacterium nucleatum( F.nucleatum)in vitro;choose 112 patients with simple gingivitis and they were randomly divided into the research group and control group.The research group(56 cases)received the treatment of Xipayiguyinye,while the control group(56 cases)received the treatment without effect components.Both groups received 7 days of treatment and then observed the changes of sulcus bleeding index ( SBI ) and plaque index ( PLI ) before and after the treatment.Results MICof Xipayiguyinye in vitro was 1.0g/L for P.gingivalis and F.nucleatum and 0.5g/L for P.intermedia.There was no statistifically significant difference in SBI and PLI between two groups before the treatment(P ＞0.05) ;there was significant difference in SBI and PLI of research group before and after the treatment ( P ＜ 0.05 ) ; there was no significant difference in SBI and PLI of control group before and after the treatment( P ＞ 0.05 ) ;there was significant difference in SBI and PLI in SBI and PLI between two groups after the treatment ( P ＜ 0.05 ).Conclusion Xipayiguyinye could prevent bacteriostasis well and decrease the accumulation of dental plaque,reduce SBI and improve the health of the gingiva in vivo.

Objective:To investigate the TCM pathogenesis of Parkinson’s disease(PD).Methods: Correlation of kidney deficiency and blood stasis and invasion of PD is analyzed based on such points as age of onset,symptoms,location,course of disease,mechanism of molecular biology and treatment.Results: It proved that deficiency of kidney and debility of marrow is the internal condition,and blood stasis is the necessary factor.Pathogenesis of PD includes the characteristic of kidney deficiency and blood stasis,deficiency correlated to stasis.In addition,Chinese herb formula with function of strengthening kidney and activating circulation shows the anti-brain-aging and neuroprotective effect to PD.Conclusion: Kidney deficiency and blood stasis is the fundamental pathogenesis of PD.

280r/40min). So the PD model was regarded eligible. In the site of lesion in SN, the number and volume of dobaminergic neurons were decreased, and the tissue structure of SN became indistinct, the levels of dopamine (DA), dihydroxyphenylaceticacid (DOPAC), homovanillicacid (HVA) 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleaceticacid (5-HIAA) were more conspicuously reduced than that in uninjured side. TH-immunoreactive cells of substantia nigra compact part were lessened obviously on injured side. The abnormal rotatory behavior of PD rats did not spontaneously disappear during 10 months of continuous observation. Conclusion The PD rat model, which is reproduced by injecting 6-OHDA to selectively destroy dopaminergic neurons in the substantia nigra of rat, is stable and reliable, and demonstrated similar primary pathological changes of PD.

Objective To explore the mechanism of therapeutic effect of Yichantang in the treatment of Parkinson′s disease (PD). Methods A rat model of PD was replicated. The experimental animals were divided into a normal control group,a normal saline control group and a Yichantang group. Changes in the rats' behavior pattern was obrerved. Using the technique of intracerebral dialysis,the content of catecholamine like substances in the nigral extracellular fluid(NECF)was measured by means of high performance liquid chromatography(HPLC). Changes in the affinity and quantity of M and DA receptors were determined too. Results Yichantang markedly improved the rats' rotation behavior,and enhanced the Bmax and KD of DA and M receptors in the brain tissues on the side of lesion. The levels of DOPAC,HVA,DA and 5-HT in the NECF of the side of lesion in the Yichantang group were significantly higher than that of the normal saline group ( P

10 mg?kg -1?d -1? 5 d. The inhibitory rate of ZD1694( 0.001- 1 000 mmol?L -1)on SGC-7901 cells were increased in concentration and time-dependent manner. The cell numbers in G_0-G_1 phase in SGC-7901 cells were raised by ZD1694 as well. CONCLUSION: ZD1694 can take obvious antitumor effects on S180-bearing mice. The antitumor rate of ZD1694 is in a dose-dependent manner, and it is higher when the total dosage is administered in one day than that the total dosage was divided into 5 consecutive days. ZD1694 can inhibit the growth of SGC-7901 cells and block the cells in G_1 phase in vitro.

Objective To discuss the influence of nursing intervention on psychological state and glu-cose control of patients with diabetes mellitns before and after intensive treatment of insulin pump. Methods 120 patients who were going to receive intensive treatment of insulin pump were divided into the control group and the observation group with 60 patients in each group by simple random method.The two groups both re-ceivecl routine nursing. The observation group was given psychological intervention along with health education by application of progressive dominant content education method. The psychological state and glucose control of the two groups were compared by χ2 test and t test. Results The score of health knowledge and satisfaction degree with health education in the observation group were higher than those of the control group.The score of anxiety and depression in the observation group decreased more significantly and satisfaction rate of glucose control was higher than that of the control group after 14 days of insulin pump treatment. Conclusions Health education to patients with intensive treatment of insulin pump by application of progressive dominant content education method can make patients to master health knowledge easily.Psychological intervention can alleviate the negative emotion of these patients and facilitate better effect of insulin pump treatment.