Stomach-qi refers to, in a broad sense, the vital qi of human body, i.e. postnatal vigorous qi and, in a narrow sense, the physiological function of spleen and stomach. Digestive function of spleen and stomach and nutrition get from diet play a key role in keeping and maintaining life and health. Human rely on the qi of food and water they take in, and qi of spleen and stomach transports and transforms the food and water, so we say, “Stomach-qi is the root of human body”. Pathologically, the stomach qi strong or declin is one of the key factors results in diseases. One will be healthy or seldom affected by disease if his or her stomach qi is not damaged; even affected by severe disease, with undamaged stomach-qi and good appetite, one will have a favorable turn. On the contrary, once the stomach-qi is hurt, one will be easily affected by evils or state of the illness will aggravate. So, “If one wants to observe the state of an illness, he or she must observe stomach-qi first; if one wants to treat a patient, he or she must consider the stomach-qi. There would be no worries, if stomach-qi is fine.” Principles for protecting stomach-qi is to treat and regulate the diseases of spleen and stomach in time and to take care of spleen and stomach when one is treating disease of other viscera.

OBJECTIVE:To investigate the effects of anisodamine combined with oxytocin on labor process of lying-in women with prolonged active phase in the first labor process and related indicators of newborns. METHODS:216 lying-in women with pro-longed active phase in the first labor process were randomly divided into control group(108 cases)and observation group(108 cas-es). All lying-in women were artificially ruptured,based on it,control group was given 2.5 u Oxytocin for injection,adding into 500 ml 5% Glucose injection by intravenous infusion,the drip rate was appropriately adjusted based on contractions;observation group was additionally given 10 mg raceanisodamine hydrochloride,adding into 10 ml 5% Glucose injection by intravenous infu-sion by 5 min slow intravenous injection. The fetal heart was warded to closely observe the labor process during medication. The cervical maturity,labor process time,delivery mode and postpartum situation of lying-in women,Apgar score,body mass and inci-dence of adverse reactions of newborn in 2 groups were observed. RESULTS:The lying-in women cases with no less than 9 cervi-cal maturity,natural delivery rate and 5 min newborn Apgar score in observation group were significantly higher than control group, lying-in women cases with 7-9 scores and less than 7 scores,cesarean section rate,perineal/ straight cut rate and 24 h postpartum hemorrhage were significantly lower than control group,the second,the third and total labor process were significantly shorter than control group,the differences were statistically significant(P<0.05);there were no significant differences in the time of incubation period and active period,forceps delivery rate,body mass of newborn and incidence of adverse reactions in 2 groups (P>0.05). CONCLUSIONS:Anisodamine combined with oxytocin can accelerate the cervical dilation of lying-in women with pro-longed active phase,shorten labor process,reduce cesarean section rate and improve prognosis,it did not affect the body mass of newborns,with good safety.

Objective To explore the causes of short P R interval syndrome.Methods 15 patients of short P R interval syndrome were tested with transesophageal atrial pacing (TEAP),and then the results and the parameters of TEAP were analyzed.Results The detection rates of dual atrioventricular nodal pathways(DAVNP),L G L syndrome and latent preexcitation syndrome were 66.67%(10/15),26.67%(4/15)and 6.67%(1/15)respectively.Conclusion The most common causes of short P R interval syndrome are DAVNP and the L G L syndrome

Objective:To explore effects of Baoyuan Huoxue Granule on senile type 2 diabetes with Qi deficiency and blood stasis,and expression rates of membrane glucoprotein selectin P(CD62p)and fibrin receptor(PAC-1)in the granule of platelet.Methods:60 cases of senile type 2 diabetes with Qi-deficiency and blood stasis were randomly divided into two groups,a simple western medicine control group(n=30)and a test group(n=30)treated by routine western medicine and Baoyuan Huoxue Granule.The treatment was given 2 months.Their clinical therapeutic effects,and the expression rates of CD62p and PAC-1 before and after treatment were investigated.Results:In the test group,12 cases(40%)were markedly effective,15 cases(50%)effective,3 cases (10%)ineffective,with an effective rate of 90%;In the control group,3 cases(10%)were markedly effective,12(40%) effective,15(50%)ineffective.the effective rate being 50%,with significant difference between the two groups in total effective rate(P

Objective To observe the influence of emotional intervention on alcohol-induced mental disor-ders patients and provide guidance for health intervention.Methods 118 patients with alcohol -induced mental disorders were divided into emotional intervention group and conventional intervention group.After 4 weeks,the effect was evaluated by anxiety,depression,SDSS,BPRS,SCL-90.Results After 4 weeks intervention,the lost rate of follow up in the emotional intervention group was 3.57%,which in the conventional intervention group was 8.06%.In the emotional intervention group, the differential values before and after intervention of anxiety, depression, BPRS, SDSS,somatization,compulsion,interpersonal relationship sensitivity,depression dimension,anxiety dimension,rivalry, consternation,crankiness and spirit were (19.90 ±3.18),(23.02 ±4.26),(15.46 ±3.29),(1.89 ±0.91), (0.48 ±0.24),(0.29 ±0.22),(0.30 ±0.24),(0.26 ±0.24),(0.31 ±0.19),(0.16 ±0.17),(0.32 ±0.20), (0.36 ±0.29),(0.35 ±0.25) respectively.Compared with the conventional intervention group,the differential values were higher than conventional intervention group [(8.27 ±1.72),(12.31 ±2.64),(11.69 ±4.17), (1.52 ±0.84),(0.25 ±0.17),(0.12 ±0.14),(0.19 ±0.18),(0.18 ±0.16),(0.15 ±0.13),(0.09 ±0.07), (0.11 ±0.12),(0.17 ±0.14),(0.16 ±0.15)].There were significant differences between the two groups (anxiety:t=4.159,P=0.000;depression:t=16.013,P=0.000;BPRS:t=5.269,P=0.000;SDSS:t=2.227,P=0.028;somatization:t=5.851,P=0.000;compulsion:t=4.883,P=0.000;interpersonal relationship sensitivity:t=2.741,P=0.001;depression:t=2.076,P=0.004;anxiety:t=5.202,P=0.000;rivalry:t=2.864,P=0.005;consternation:t=6.749,P=0.000;crankiness:t=4.432,P=0.000;spirit:t =4.885,P=0.000).Conclusion Emotional intervention has positive effect on emotional states,somatic symptoms and quality of life,it is worthy of clin-ical promotion.

Objective To evaluate the prophylactic efficacy and safety of posaconazole against invasive fungal disease(IFD)in hematologic patients with neutropenia.Methods Medical records of 18 hematologic patients with neutropenia received posaconazole for preventing IFD in a Beijing hospital between 2014 and 2015,the efficacy and safety was evaluated.Results There was no clinical diagnosis or confirmed diagnosis of IFD among 18 patients during posaconazole prophylaxis period,none of patients stopped posaconazole due to severe adverse reaction.Two patients with acute myeloid leukemia(AML) died of pulmonary infection,1 of whom isolated Stenotrophomonas maltophilia from sputum culture on the 12th day of posaconazole prophylaxis,the other isolated Escherichia coli from sputum culture on the 14th day of posaconazole prophylaxis.Other patients all adherence to posaconazole prophylaxis until granulocyte count recovered,patients were followed up until 100 days medication,no death occurred.The lowest peripheral neutrophil count was(0.00-0.27) x 109/L during posaconazole prophylaxis period,with the median of 0.02 x 109/L;the duration of posaconazole prophylaxis was 8-27days,with the median of 16 days;among patients without IFD breakthrough or received systemic use of other antifungal agents,there were 2 (11.1％) all-cause death within 100 days;there were no adverse reaction,such as liver function abnormalities≥grade 2 and kidney function abnormalities≥grade 2,as well as QTc prolongation.Conclusion Posaconazole is effective for preventing IFD in hematologic patients with neutropenia,adverse reaction is rare.

To compare the anxiolytic effects of reduced metabolite of progesterone and benzodiazepine.Methods　The effects of allopregnanolone and diazepam on spontaneous locomotor activity and on exploration in the elevated plus-maze were studied in C57 mice 20 min after vehicle or drug intraperitoneal administration.Results Allopregnanolone (0.1 mg.kg-1,ip) elicited marked anxiolytic effects in terms of significantly reducing the latency to enter the open arm from (31.30±8.39)s to (8.80±6.00)s,(P<0.001),and significantly increasing both the number of open arm entries from 1.20 ± 0.42 to 4.80 ±1.75,(P<0.001) and the proportion of total time spent on the open arm from 7.13％ to 32.50％,(P<0.001).Meanwhile,the diazepam (0.25 mg·kg-1) produced a lower anxiolytic effect comparing to that of the allopregnanolone.Analysis of spontaneous locomotor activity showed while 0.5 mg·kg-1 of diazepam decreased the locomotor activity (P<0.01),neither 0.1 mg·kg-1 of allopregnanolone nor 0.25 mg·kg-1 of diazepam affect the locomotor activity score.Conclusion Together,these results provide evidence for differential behavioral actions of the neurosteroids and benzodiazepines.Since the allopregnanolone produce a selective anxiolytic effect without affecting the spontaneous locomotor activity,the allopregnanolone may be a better alternative for diazepam in treating anxiety.

Objective To discuss the diagnostic value of high frequency ultrasound on lesions of knee traumas.Methods Ninty-eight cases with post-traumatic knee injuries were examined by high frequency ultrasound,and the characteristics of changing ultrasonogram were observed and comparing with surgical results and MR.Results Of the 98 cases with post-traumatic knee injuries,there were 57 cases with effusion and hematocele in knee joint,among which there were 41 cases with collateral ligaments and meniscus injuries,the diagnostic coincidence rate was 93.3% in tendon tear and complete tendon fracture(compared with MR),91.7% in partial and complete muscle tear(compared with MR),67.7% and 71.4% in collateral ligaments and meniscus injuries(compared with surgical results).Conclusions High frequency ultrasound can be used as a conventional imaging examination method for post-traumatic knee injuries.

Objective To determin and compare the significance of the expression of chemotactic cytokines in pleural effusions monocyte chemoattractant protein-1(MCP-1)and regulated on activation,normal,T-cell expressed and secreted(RANTES)levels in tuberculous and malignant pleural effusions.Methods The effusion and serum levels of MCP-1 and RANTES were measured in 37 patients with tuberculous pleural effusion and 35 patients with malignant pleural effusion,and selected 20 healthy people acting as control group.Results The effusion and serum levds of MCP-1 and RANTES in tuberculous effusion patients was significantly higher than that in malignant group(P＜0.01);In tuberculous group,the content of MCP-1 in serum was higher than control group,the serum level of RANTES was no statistic significant difference between control group and tuberculous group.The contents of MCP-1 and RANTES were not correlated with pathologic type of lung.cancer.Conclusion MCP-1 and RANTES technique has an important clinical value in diagnosis and differential diagnosis of tuberculosis and malignant pleural effusion.

AIM: To investigate the effect of soybean isoflavones (SI) on ventricular remodeling induced by myocardial infarction (MI). METHODS: MI was induced by permanent ligation of the left anterior descending coronary artery (LAD) in male Sprague-Dawley (SD)rats. Rats were randomly divided into six groups: shamThree hours after the operation, the drugs or solvent were administrated ig qd for 35 d. Twenty-four hours after the last administration, heart rate (HR), left ventricular end-diastolic pressure (LVEDP), peak systolic left ventricular pressure (Peak), maximal rate of left ventricular pressure rising (+dp/dtmax), maximal rate of left ventricular pressure declining (-dp/dtmax) and myocardial maximal shortening velocity (Vmax) were measured. After above hemodynamic parameters were measured, hearts were extracted. The ratio of total ventricle weight to body weight(TVW/BW) was calculated. Myocardial collagen was shown with the collagen-specific picrosirius red stain,myocardial interstitial collagen volume fraction(ICVF), perivascular collagen volume fraction(PCVF), infarct size,septal thickness (ST) and left ventricular diameter (LVD) were measured by image analysis system. RESULTS:(31 ± 5) %, respectively, all of which were significantly smaller than that in MI group (( 38.9 ± 2.9) %, P ＜ 0.01 ).In MI group, TVW/BW, LVD, ICVF and PCVF were remarkably increased compared with those in sham group (P ＜ 0.01 ). The increased TVW/BW, LVD, ICVF and PCVF were significantly reduced by treatment with eaprats in MI group was significantly decreased than that in sham group (P ＜ 0.01 ). The reduced ST could be in-dp/dtmax and Vmax were decreased (P ＜ 0.01 ), while LVEDP was increased (P ＜ 0.01 ), significantly. The reSION: SI can improve cardiac function and ventricular remodeling induced by myocardial infarction in the rat.