To evaluate the efficacy of intravenous administration of aminocaproic acid in pre-venting secondary hemorrhage after traumatic hyphemas. Methods: 60 patients with traumatic hyphemaswere random separated into two groups: (1 ) Routine treated group: 31 patients received intramuscular ad-ministration of adrenosin or dicynone and oral administration of steroids t (2) Arninocaproic acid treatedgroup: 29 patients received aminocaproic acid in an intravenous drip. Results: The incidence of secondaryhemorrhage in the amin0caproic acid treated group was much lower than that in the routine treated group(P

Objective To evaluate the application value of detachable balloon in today's interventional neuroradiology. Methods 38 cases with vascular lesion in the area of cranial cervical region ( 26 cases with CCF, 3 with giant aneurysm in the cavernous segment of internal carotid artery, one with fusiform aneurysm in internal carotid artery, and 8 with AVF in the area of cranial cervical) were treated by detachable balloon for embolizing the shunt or scrificing the lesion ipsilateral internal carotid artery. Results All 38 cases were cured without complication and sequeulae. Of them, anatomical cure was aquired in 21 cases, lesion cure in 17 cases. Conclusions Detachable balloon is still the first choice of embolization material in today's endovascular therapy of some vascular lesions in the area of cranial cervical region.

Objective:To study the relative bioavailability of sirolimus ( SRL) dropping pills in rats. Methods:PEG6000 as the base, SRL dropping pills were prepared using solvent-melting method. The SRL marketed tablets as the reference preparation and rats as the animals, the relative bioavailability of SRL dropping pills was studied to obtain the pharmaceutical parameters and bioequiavail-ability. Results:Compared with that of the reference preparation, tmax of SRL dropping pills was the same (1 h). There was no signifi-cant difference in Cmax between the dropping pills and the tablets (P>0. 05). AUC0-24 of the dropping pills was notably higher than that of the marketed tablets (P<0. 05) with the bioequiavailability of 121. 98%. Conclusion:SRL dropping pills with promising bioavail-ability are valuable to be studied further.

Objective: In T_(739) inbred line mice,bladder cancer model was established via tumor source transplant.In order to get insights of the biological effects of implanting ~(125)I seed to treat bladder cancer,the development and the pathological modality of tumor tissues were observed through the experiment of implanting ~(125) I seed.The experiment was to provide theoretical gist and practical guidance for clinical(utilization) of ~(125)I seed for brachytherapy of bladder cancer. Methods: 16 T_(739) inbred line mice were divided into two groups(A:experimental group,n=8;B:control group,n=8) in random;bladder cancer model was established via tumor source transplant.When the diameter of the transplanting tumor was about 0.7 cm,~(125)I seeds were implanted at the tumor of experimental group while the empty seed was penetrated into the control group at the same position as the experimental group and the experimental mice were executed after 24 days.The longest vertical diameters(a) and(b) of tumor body were observed every 3 days and the volume of tumor body(V=ab~(2)/2) was calculated.Combining with the weight of mouse(W) and the weight of tumor body after execution of mice(w),the growth curve of tumor was protracted and the colony redouble time and tumor suppression rate were calculated.After fixation of formaldehyde,the pathological modality of tumor tissues were observed with HE staining. Results: ① The transplantation was 100% successful and there was no natural fade-away phenomenon.②After implantation of seed,the weight of group A mice increased by(4.93?0.60)g,and group B increased by(13.60?1.15)g(P

The main complications of Kawasaki diseases(KD) is relative to cardiovascular,especially coronary artery.Coronary artery lesions can be showed as arteritis,artery dilatation,aneurysm,arterial stenosis and so on.As a noninvasive,convenient,fast and well reproducible inspection method,echocardiography can offer dynamically observa tion of the evolution process of coronary artery lesions in each stage,accurately measure the coronary artery diameter,evaluate heart function in children,find other cardiac complications and which has become a standard diagnosis technics.With upgrades and new technology,the echocardiography plays a more and more important role in the diagnosis of acute period of KD and observation of curative effect,prognosis and long-term follow-up of recovery period of KD.

To investigate the role of intercellular adhesion molecule 1(ICAM 1) in the pathogenesis of bacterial keratitis,22 rats were randomly divided into bacterial keratitis group and control group. A specific staining of corneal epithelial cells, stromal keratocytes and endothelial cells for ICAM 1 was carried out by using monoclonal antibody to ICAM 1 and immunohistochemical staining techniques. The results showed that ICAM 1 expressed a low level in the corneal epithelial cells, stromal keratocytes and endothelial cells in the control group(-~+), while its expression was strong in the keratitis group (~). The difference between two groups was statistically significant ( P

Objective To investigate the effects of acupuncture on gene expression profile of neurotrophin and its receptors in cerebral cortex of neonatal rats after cerebral hypoxic-isehemic injury,and to explore the molecu- lar mechanism of acupuncture in treatment of neonatal hypoxic-ischemic encephalopathy.Methods The model of cerebral hypoxic-ischemic injury was established with 10 neonatal Sprague-Dawley(SD)rats,who were subjected to acupuncture once daily for 14 days.The animals were sacrificed on the next day of the last acupuncture and their brain cortex was sampled for examination of gene expression,using GEArray Q series neurotrophin and receptors gene array.Results After 14 days of acupuncture,it was found that 48 genes(50% of total genes on the microarray) were expressed differently between the two groups,of which 40 genes(83.3% of differently expressed genes),such as those of the brain-derived neurotrophic factor(BDNF),ciliary neurotrophic factor(CNTF),ciliary neurotrophic factor receptor(CNTFR),basic fibroblast growth factor(bFGF)and fibroblast growth factor receptor type 1 (FGFR1)were up-regulated,and 8 genes(16.7% of differently expressed genes),such as genes of neuregulin-1 (Nrg1),neuregulin-4(Nrg4)and tyrosine kinase C(TrkC)were down-regulated.Conclusion Acupuncture can regulate the expression of various genes of neurotrophin and receptors in cerebral cortex of neonatal rats after cerebral hypoxic-ischemic injury,which might be the mechanism of acupuncture facilitating the recovery of the rats from hy- poxic-ischemic encephalopathy.

Objective: To evaluate the pharmacological actions on blood quickening and stasistransforming of Gongqing Granules (Herba Leonuri, Herba Portulacae, Pollen Typhae, etc).Methods:Fibrinolysin dissolving, blood stagnation model induced by adrenaline hydrochloride, natural bleeding, capillary coagulation.Results: Gongqing Granules could obviously increase whole blood and plasma viscosities and packed cell volume, and obviously shorten the time of fibrionolysin dissolving. It showed no evident effect on the time of bleeding in mice and could shorten the time of capllary blood coagulation in rats.Conclusion: Gongqing Granules has strong actions of blood quickening and stasis transforming.

Objective:To evaluate the cough-settling, phlegm-dispelling and panting-calming actions of Ginkgo Distillate. Methods: The cough-settling and phlegm-dispelling effects were observed on the ammonia water-induced cough model of mice and phenol red expectoration method. The panting-calming effect was observed by wheezing and panting incubation period and relaxation test of isolated tracheal smooth muscle. Results: Ginkgo Distillate could inhibit mouse cough induced by ammonia water, promote mouse tracheal expectoration induced by phenol red, remit the wheezing and panting induced by histamine phosphate, prolong the wheezing and panting incubation period. It also possessed the inhibition on guinea pig tracheal contraction induced by histamine phosphate. Conclusions: Ginkgo Distillate has the cough-settling, phlegm-dispelling and panting-calming actions.