Objective To explore the effect of individualized multiple-nutritional evaluation for patients with bone cancer. Methods Totals of 94 cases with bone cancer were divided into the control group and observation group(with 47 patients in each group) from January 2012 to December 2013. The control group received conventional nursing during chemotherapy, while the observation group was given individualized multiple-nutritional evaluation. The differences in serum albumin, level of dietary knowledge and the postoperative complications were compared at different periods of time. Results In the observation group, the serum albumin at admission and 1 week after admission were not significantly different (P >0. 05). After 4 weeks, the serum albumin of observation group was (33. 41 ± 1. 31) g/L, which was significantly different with the control group (t=5. 117,P<0. 05). In the observation group, the dietary knowledge at admission was not significantly different (P>0. 05). After 1 and 2 weeks, the dietary knowledge of observation group were (10.47 ±1. 33) and (9.56 ±1.28), which were significantly different with the control group (t =2. 935, 3. 297,respectively;P<0. 05). The complication of abdominal pain, diarrhea, abdominal distension and nausea and vomiting in the observation group were significantly lower than those of the control group (χ2 =6. 351, 4. 039,4. 663,4. 417,respectively;P<0. 05). Conclusions The individualized multiple-nutritional evaluation cannot only effectively improve the nutritional status of patients with bone cancer, but also reduce incidence of gastrointestinal complications.