With the extensive use of information technology and the development of big data technology, the traditional treatment methods for cancer are not meeting our needs.The application of medical large data has now changed our tumor treatment model profoundly, but also brings a deeply cognition to the nature of malignant tumor.Development of medical big data analysis and management technologies are driving malignancy treatment model fromindividual treatment era into the precision medicine era, which allows us to change the prediction, diagnosis, treatment and monitor of malignancy.There are also a variety of challenges to resolve.

Objective To compare the precision and correlation of test parameters betwee the two types of automatic blood ana-lyzer,Sysmex XT-2000i and Mindray BC-5800.Methods We selected 60 cases of EDTA-K2 anticoagulant whole blood samples, correlation analysis was carried out on the two instrument parameters,and high,medium and low value samples were chosen for 10 times′precision analysis in the two instrument s respectively.Results The variation coefficient(CV)values of blood count parame-ters of Sysmex XT-2000i were 0.02%-5.70%,while the CV values of white blood cell classification parameters were 0.06%-1. 66%.The CV values of blood count parameters of Mindray BC-5800 were 0.02%-5.3%,white the CV values of white blood cell classification parameters were 0.09%-1.17%.The determination coefficient(r2 )of each parameter of the two instruments were 0. 185-0.995.Conclusion the correlation between the two instruments is good,and the two instruments′precisions were consistent with the design range.

Objective To investigate the correlations of serum calcium,25-hydroxyvitamin D and uric acid levels with benign paroxysmal positional vertigo(BPPV).Methods A total of 96 pa-tients with BPPV were enrolled in vertigo group and further divided into mild vertigo(30 cases),moderate vertigo(42 cases),and severe vertigo(24 cases)groups based on the severity of vertigo symptoms.Additionally,63 healthy people undergoing physical examination without BPPV were re-cruited as control group.Serum calcium,25-hydroxyvitamin D,and uric acid levels were compared among groups,and their correlations with the severity of vertigo in BPPV patients were analyzed.Fol-low-up was conducted for 3 months to record the recurrence rate of BPPV.Results The serum calci-um and 25-hydroxyvitamin D levels in the moderate and severe vertigo groups were significantly lower,while uric acid levels,total score of Dizziness Handicap Inventory(DHI)as well as functional,emo-tional,and physical scores were significantly higher than those in the mild vertigo group and control group(P＜0.05).Moreover,the severe vertigo group exhibited lower serum calcium and 25-hydroxyvitamin D levels and higher uric acid level,DHI total score and functional,emotional,as well as physical scores(P＜0.05).No significant differences were observed in serum calcium,25-hydroxyvitamin D,uric acid levels,or DHI scores between the mild vertigo group and the control group(P＞0.05).The severity of vertigo in BPPV patients was negatively correlated with serum calcium(r=-0.557,P＜0.05)and 25-hydroxyvitamin D levels(r=-0.467,P＜0.05),and positively correlated with uric acid levels(r=0.504,P＜0.05).The 3-month recurrence rate of BPPV was 8.33％(8/96).Compared to patients with serum calcium ≥2.11 mmol/L,25-hydroxyvitamin D ≥30 ng/mL,and uric acid ≤428 μmol/L,those with serum calcium＜2.11 mmol/L,25-hydroxyvitamin D＜30 ng/mL,and uric acid＞428 μmol/L had significantly higher BPPV recurrence rates(P＜0.05).Conclu-sion BPPV patients exhibit abnormally lower serum calcium and 25-hydroxyvitamin D levels and abnormally higher uric acid levels.The severity of vertigo in BPPV patients is negatively correlated with serum calcium and 25-hydroxyvitamin D levels and positively correlated with uric acid levels.

Objective To investigate the correlations of serum calcium,25-hydroxyvitamin D and uric acid levels with benign paroxysmal positional vertigo(BPPV).Methods A total of 96 pa-tients with BPPV were enrolled in vertigo group and further divided into mild vertigo(30 cases),moderate vertigo(42 cases),and severe vertigo(24 cases)groups based on the severity of vertigo symptoms.Additionally,63 healthy people undergoing physical examination without BPPV were re-cruited as control group.Serum calcium,25-hydroxyvitamin D,and uric acid levels were compared among groups,and their correlations with the severity of vertigo in BPPV patients were analyzed.Fol-low-up was conducted for 3 months to record the recurrence rate of BPPV.Results The serum calci-um and 25-hydroxyvitamin D levels in the moderate and severe vertigo groups were significantly lower,while uric acid levels,total score of Dizziness Handicap Inventory(DHI)as well as functional,emo-tional,and physical scores were significantly higher than those in the mild vertigo group and control group(P＜0.05).Moreover,the severe vertigo group exhibited lower serum calcium and 25-hydroxyvitamin D levels and higher uric acid level,DHI total score and functional,emotional,as well as physical scores(P＜0.05).No significant differences were observed in serum calcium,25-hydroxyvitamin D,uric acid levels,or DHI scores between the mild vertigo group and the control group(P＞0.05).The severity of vertigo in BPPV patients was negatively correlated with serum calcium(r=-0.557,P＜0.05)and 25-hydroxyvitamin D levels(r=-0.467,P＜0.05),and positively correlated with uric acid levels(r=0.504,P＜0.05).The 3-month recurrence rate of BPPV was 8.33％(8/96).Compared to patients with serum calcium ≥2.11 mmol/L,25-hydroxyvitamin D ≥30 ng/mL,and uric acid ≤428 μmol/L,those with serum calcium＜2.11 mmol/L,25-hydroxyvitamin D＜30 ng/mL,and uric acid＞428 μmol/L had significantly higher BPPV recurrence rates(P＜0.05).Conclu-sion BPPV patients exhibit abnormally lower serum calcium and 25-hydroxyvitamin D levels and abnormally higher uric acid levels.The severity of vertigo in BPPV patients is negatively correlated with serum calcium and 25-hydroxyvitamin D levels and positively correlated with uric acid levels.

Objective:To investigate the short-term clinical effect of using fibular flap with preserving the continuity of fibula in hip preservation surgery for femoral head necrosis.Methods:From September, 2017 to November, 2020, 13 cases of femoral head necrosis were repaired with fibular flap. The fibular flaps were cut with an improved method for preserving the continuity of the fibular cortex, and the donor sites were sutured directly. The fibuls were inserted into the femoral heads with single or double segment folding support. Autogenous iliac crest combined with platelet-rich plasma(PRP) was used for impaction of bone grafting in femoral head, and the fibular flaps were anastomosed with 1 artery and 2 veins. All follow-up data were obtained, including bone union by X-ray and CT as well as the functional recovery of the hip joint and donor site. Statistical analysis was performed. P<0.05 was considered statistically significant. Results:The followed-up time ranged from 6 to 23 months. The fibular bones were significantly thicker and the incisions healed well at the donor sites. There was neither abnormal sensation in toes, dorsal foot, and lateral of the leg, nor significant influence on foot function. The hip joint activities were normal. The outcome was proved to be remarkable according to the Harris score(from 58.9±10.6 points before surgery to 81.7±10.6 points after surgery), the difference was statistically significant ( P<0.05) . Conclusion:The method of the improved fibular flap in hip preservation surgery is beneficial to the repair and reconstruction of the necrotic femoral head since the donor area is less traumatic, and a satisfactory clinical effect can be obtained.