Objective:To explore the effect of rehabilitation nursing guided by precision nursing theory on the health belief and self-management behavior of patients with myocardial infarction after percutaneous coronary intervention (PCI) .Methods:Using the convenient sampling method, a total of 184 patients with myocardial infarction who received PCI treatment at Queshan County People's Hospital from January 2020 to January 2021 were selected as the research objects. According to the random number table method, they were divided into the observation group and the control group, with 92 cases in each group. The control group was given routine postoperative nursing, while the observation group was given rehabilitation nursing guided by precise nursing. Health Belief Scale and Self-management Scale were used to evaluate the effect of intervention.Results:Repeated measures analysis of variance showed that total scores of health beliefs and self-management behavior of patients in two groups existed time, the interaction effect between groups, time and between groups ( P<0.05) . Conclusions:Rehabilitation nursing guided by precision nursing theory can improve the health belief level and self-management behavior of patients with myocardial infarction after PCI.