1.Current situation and control strategies of H9N2 avian influenza in South Korea
Mingeun SAGONG ; Kwang-Nyeong LEE ; Eun-Kyoung LEE ; Hyunmi KANG ; Young Ki CHOI ; Youn-Jeong LEE
Journal of Veterinary Science 2023;24(1):e5-
The H9N2 avian influenza (AI) has become endemic in poultry in many countries since the 1990s, which has caused considerable economic losses in the poultry industry. Considering the long history of the low pathogenicity H9N2 AI in many countries, once H9N2 AI is introduced, it is more difficult to eradicate than high pathogenicity AI. Various preventive measures and strategies, including vaccination and active national surveillance, have been used to control the Y439 lineage of H9N2 AI in South Korea, but it took a long time for the H9N2 virus to disappear from the fields. By contrast, the novel Y280 lineage of H9N2 AI was introduced in June 2020 and has spread nationwide. This study reviews the history, genetic and pathogenic characteristics, and control strategies for Korean H9N2 AI. This review may provide some clues for establishing control strategies for endemic AIV and a newly introduced Y280 lineage of H9N2 AI in South Korea.
2.Development and characterization of stable cell lines constitutively expressing the porcine reproductive and respiratory syndrome virus nucleocapsid protein.
Mingeun SAGONG ; Choi Kyu PARK ; Seong Hee KIM ; Sung Up MOON ; Seong Cheol CHO ; Changhee LEE
Journal of Veterinary Science 2010;11(2):169-171
Despite global efforts to control porcine reproductive and respiratory syndrome virus (PRRSV) infection, the virus continues to cause economic problems in the swine industry worldwide. In this study, we attempted to generate and characterize a panel of stable BHK cell lines that constitutively express the nucleocapsid (N) protein of type 1 or type 2 PRRSV. The established BHK cell lines were found to react well with N-specific antibodies as well as the hyperimmune serum of pigs raised against each genotype of PRRSV. Taken together, the data implicate a potential usefulness for the newly generated stable cell lines as a diagnostic reagent for PRRSV serology.
Animals
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Antibodies, Viral/analysis/immunology
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Blotting, Western/veterinary
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Cell Line
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Cricetinae
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Female
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Genotype
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Nucleocapsid Proteins/genetics/*immunology
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Porcine Reproductive and Respiratory Syndrome/diagnosis/*immunology
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Porcine respiratory and reproductive syndrome virus/genetics/*immunology
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Swine
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Transfection/veterinary
3.Genetic characterization of H9N2avian influenza virus previously unrecognized in Korea
Gyeong-Beom HEO ; Soo-Jeong KYE ; Mingeun SAGONG ; Eun-Kyoung LEE ; Kwang-Nyeong LEE ; Yu-Na LEE ; Kang-Seuk CHOI ; Myoung-Heon LEE ; Youn-Jeong LEE
Journal of Veterinary Science 2021;22(2):e21-
In this study, we describe the isolation and characterization of previously unreported Y280-lineage H9N2 viruses from two live bird markets in Korea in June 2020. Genetic analysis revealed that they were distinct from previous H9N2 viruses circulating in Korea and had highest homology to A/chicken/Shandong/1844/2019(H9N2) viruses. Their genetic constellation showed they belonged to genotype S, which is the predominant genotype in China since 2010, where genotype S viruses have infected humans and acted as internal gene donors to H5 and H7 zoonotic influenza viruses. Active surveillance and control measures need to be enhanced to protect the poultry industry and public health.
4.Genetic characterization of H9N2avian influenza virus previously unrecognized in Korea
Gyeong-Beom HEO ; Soo-Jeong KYE ; Mingeun SAGONG ; Eun-Kyoung LEE ; Kwang-Nyeong LEE ; Yu-Na LEE ; Kang-Seuk CHOI ; Myoung-Heon LEE ; Youn-Jeong LEE
Journal of Veterinary Science 2021;22(2):e21-
In this study, we describe the isolation and characterization of previously unreported Y280-lineage H9N2 viruses from two live bird markets in Korea in June 2020. Genetic analysis revealed that they were distinct from previous H9N2 viruses circulating in Korea and had highest homology to A/chicken/Shandong/1844/2019(H9N2) viruses. Their genetic constellation showed they belonged to genotype S, which is the predominant genotype in China since 2010, where genotype S viruses have infected humans and acted as internal gene donors to H5 and H7 zoonotic influenza viruses. Active surveillance and control measures need to be enhanced to protect the poultry industry and public health.
5.Novel reassortants of clade 2.3.4.4 H5N6 highly pathogenic avian influenza viruses possessing genetic heterogeneity in South Korea in late 2017
Yu Na LEE ; Sun Ha CHEON ; Soo Jeong KYE ; Eun Kyoung LEE ; Mingeun SAGONG ; Gyeong Beom HEO ; Yong Myung KANG ; Hyun Kyu CHO ; Yong Joo KIM ; Hyun Mi KANG ; Myoung Heon LEE ; Youn Jeong LEE
Journal of Veterinary Science 2018;19(6):850-854
Novel H5N6 highly pathogenic avian influenza viruses (HPAIVs) were isolated from duck farms and migratory bird habitats in South Korea in November to December 2017. Genetic analysis demonstrated that at least two genotypes of H5N6 were generated through reassortment between clade 2.3.4.4 H5N8 HPAIVs and Eurasian low pathogenic avian influenza virus in migratory birds in late 2017, suggesting frequent reassortment of clade 2.3.4.4 H5 HPAIVs and highlighting the need for systematic surveillance in Eurasian breeding grounds.
Agriculture
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Animals
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Birds
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Breeding
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Ducks
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Ecosystem
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Genetic Heterogeneity
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Genotype
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Influenza in Birds
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Korea