Objective:To explore the influence of health education based on Information-Motivation-Behavior Skills (IMB) model on the self-management of fistula in patients with autogenous arteriovenous fistula (AVF) plasty.Methods:A total of 112 patients undergoing AVF plasty from October 2020 to October 2021 were selected and divided into 2 equal group by the random number table method. The control group used usual care and health education. The observation group implemented a health education intervention based on the IMB model .Repeated-measures ANOVA were used to compare the difference of self-efficacy, self-management ability of AVF between before, 4, 8, and 12 weeks after intervention.Results:Before the intervention, there were no significant differences between the two groups about the scores of AVF scale and the general self-efficacy scale (all P>0.05). After 4 weeks, 8 weeks and 12 weeks of intervention, the total scores of Self-management ability of AVF were (56.27 ± 6.12), (64.51 ± 4.40) and (73.53 ± 3.60), which were significant higher than those of in the control group (49.38 ± 4.50), (57.93 ± 6.70) and (59.36 ± 5.28)( t=6.73, 6.06, 16.44, all P<0.05). Conclusion:Health education based on IMB model can improve the self-management ability and self-efficacy of patients undergoing AVF plasty with a more long-term impact on patients.