Objective To investigate the effects of obesity on functional residual capacity ( FRC ) , ventilatory function and gas exchange during and after cholecystectomy. Methods Twenty ASA Ⅰ or Ⅱ patients of both sex aged 26-58yr undergoing elective cholecystectomy were divided into 2 groups according to the body mass index (BMI): control group BMI 30 (n = 10) . The patients were premedicated with intramuscular luminal 1.0 g and atropine 0.5 mg. Anesthesia was induced with midazolam 2-3 mg, fentanyl 5?g?*kg-1, propofol 1.5-2.0 mg?kg and vecuronium 0.1 mg?kg-1 and maintained with infusion of propofol (at 8-10 mg?kg-1?h-1) and fentanyl (at 1-2 ?g?kg-1?h-1) and intermittent i.v. boluses of vecuronium after tracheal intubation. The patients were mechanically ventilated (VT 10ml?kg-1,I:E=1:2, FiO2 100%) and PETCO2 was maintained at 35-40 mm Hg by adjusting the respiratory rate. Pethidine 1 mg?kg-1 was given i.m. every 8 h after operation for analgesia. BP, HR, ECG, SpO2, PET CO2 , FiO2, VT , RR were monitored during anesthesia. Arterial blood samples were taken before anesthesia (T0, baseline), 15 min after induction of anesthesia (T1), 30 min after skin incision (T2) and 6, 24 h after operation (T3,4) for blood gas analysis. FRC (closed-circuit helium dilution method), forced vital capacity (FVC), forced expiratory volume at 1 second (FEV10) and maximal mid-expiratory flow volume (MMF) were measured before and 6 h and 24 h after operation.Results FRC was significantly decreased after induction of anesthesia, during and after operation compared with the baseline value (T0) in both groups and the decrease in FRC was significantly larger in obesity group than in control group (P

BACKGROUND: Pericytes and other perivascular stem cells are gaining increasing attention in bone tissue engineering. Pericytes have been long thought to regulate blood pressure and promote angiogenesis. However, it is now considered to have the characteristics of mesenchymal stem cells, including pluripotency, self-renewal, immune regulation, and tissue repair, showing strong regenerative potential in common orthopedic diseases such as fractures, nonunion, vertebral fusion, ligament rupture, and cartilage injury. OBJECTIVE: To summarize the related applications of pericytes in orthopedics, and to explore mechanisms, strengths and limitations.METHODS: With “pericytes, perivascular stem cells, repair, therapy, orthopedics” as Chinese and English retrieval terms, we systematically searched databases including PubMed, Web of Science, CNKI and WanFang, from inception to August 2019 for the articles concerning the treatment of orthopedic diseases with pericytes. A total of 112 related documents were retrieved. After reading the full text, 55 eligible documents were selected. RESULTS AND CONCLUSION: Pericytes are a kind of emerging stem cells that have been reported in many studies regarding the treatment of orthopedic diseases, and have a greatly therapeutic prospect. There are abundant pericytes in the body with no need for in vitro culture. The repair mechanism of pericytes is mainly related to paracrine mediation, with self-differentiation as a secondary mechanism. However, its specific mechanism remains unclear, which needs further investigations.

Objective: To test the relationship between duration of physical exercise and sadness of middle school students, so as to provide enlightenment for students to participate in physical exercise when they are faced with sadness. Methods: Through the methods of multiple linear regression and regulatory effect test, data of 8 146 middle school students from China Education Panel Survey 2014-2015 were analyzed. Results: A negative correlation was observed between physical exercise duration and sadness of middle school students (r=-0.08, P<0.01); physical exercise duration showed significant negative main effect on depressive mood of middle school students (β=-0.05,P<0.01); the square term of physical exercise students shows significant curve correlation with depressive mood of middle school students (β=-0.04, P<0.05); physical exercise students had significant negative main effect on depressive mood of urban and rural middle school students(β=-0.04,-0.05, P<0.01); the square term of physical exercise duration does not show significant curve correlation with depressive mood of rural middle school students (β=-0.01, P>0.05), but showed significant curve correlation with depressive mood of urban middle school students (β=-0.06, P<0.01). Conclusion Physical exercise duration has threshold effect on relieving middle school students’ Sadness, while the threshold effect of rural middle school students physical exercise time disappears. Attention should be paid to the understanding of the relationship between physical exercise duration and sadness of middle school students.

Objective To investigate the value of coronary CT angiography (CCTA) in the follow up observation of coronary heart disease in high-risk population.Methods Totally 80 coronary atherosclerotic plaque patients underwent CCTA.The fasting blood sugar,blood lipid (triglycerides,total cholesterol,high-density lipoprotein,low-density lipoprotein) and body mass index of all patients showed two or more abnormalities.After clinical intervention,CCTA examination,serum biochemical indexes and body mass index were tested again two years later.According to the degree of coronary artery stenosis quantitative assessment results,the patients were divided into stable group and progress group.All parameters before and after the two checks were statistically analyzed.Results According to the results of CCTA,stable group included 60 cases and progress group included 20 cases.The statistically significant difference was found between the first and second examination of high-density lipoprotein in the progress group were (t=2.64,P=0.02).The body mass index,blood glucose,triglyeerides,total cholesterol and low-density lipoprotein (LDL) of the second test in stable group were significantly lower than those of the first check (t=2.10,2.68,3.45,4.26,5.90,P=0.04,0.01,0.001,0.000 1,0.000 1),while triglyceride (t=2.39,P=0.02) and LDL in the second check in progress group were both higher than those of the second check in stable group (t=3.98,P＜0.000 1),and the rate of change of blood sugar in the progress group was higher than that in the stable group (t =-2.04,P=0.045).Conclusion CCTA plays positive role in the follow up observation of high-risk population of coronary heart disease.Guiding the active intervention of the risk factors and promoting the patients to change the bad habits can effectively delay or prevent the occurrence and development of coronary heart disease.