Folium Perillae (FP) is a traditional Chinese materia medica, which has been used for treating inflammatory diseases. In order to clarify the material basis of FP' s pharmacological activity and anti-inflammatory mechanism, we presented a review about some of the primary chemical components in FP, such as volatile oils, flavonoids, anthocyanins, phenolic acids, glycosides, triterpenes and steroids, and about the anti-inflammatory activity of FP extract and its major mechanism, such as regulating the viability and function of innate immune cells, controlling the balance of helper T cells, based on related research in recent years. This study aims to provide reference for further research and development of new drugs based on FP.

Objective To explore the volume size of mastoid pneumatization in normal adults and the relation‐ship with a history of recurrent otitis media in childhood .Methods A total of in 40 adults (80 ears) ,based on with or without otitis media in childhood ,were divided into the study group (n= 20) and the control group (n=20) . The volume sizes of mastoid pneumatization were measured by temporal bone CT scanning of three-dimensional re‐construction ,and the relationship with the history of childhood ear infections was studied .Results The average vol‐ume of pneumatization in all 80 temporal bones was 10 .4 ± 1 .8 ml .The average volume of pneumatization in sub‐jects without otitis media history (48 ears) and subjects with a history of otitis media (32 ears) were 9 .7 ± 2 .2 ml and 6 .3 ± 1 .7 ml ,respectively .The difference was statistically significant (P<0 .05) .For the subjects with single ear disease in the study group ,the average volume of pneumatization in subjects without otitis media history(8 ears) and subjects with a history of otitis media(8 ears) were 9 .2 ± 1 .3 ml and 5 .8 ± 3 .6 ml ,respectively ,and there were statistically significant differences(P<0 .05) .The average volume of pneumatization in the control group (40 ears) was 10 .1 ± 4 .4 ml .Comparing with the subjects with out otitis media history(8 ears) in the study group ,there was no statistically significant difference (P>0 .05) .Conclusion The volumes of mastoid pneumatization in normal ears have a wide range .The subjects with a history of recurrent otitis media in childhood may be the cause of the volume decrease of mastoid pneumatization in adulthood .

AIM:To explore the effects of confluent endothelial progenitor cells (EPCs) derived from young and aged rats on the phenotype conversion, proliferation and migration of vascular smooth muscle cells ( SMCs) .METH-ODS:Mononuclear cells were obtained from the bone marrow of young (1~2 month old) and aged (19 to 26 month old) Sprague-Dawley rats and cultured with medium DMEM/F12 ( containing 15% fetal bovine serum, endothelial cell growth supplements (ECGs) 100 g/L, 1 ×105 units/L of penicillin and streptomycin, respectively).EPCs were characterized as double positive for DiI-Ac-LDL uptake and lectin binding.Abdominal aorta was obtained from 1 to 2 month old Sprague-Dawley rats.Vascular SMCs were cultured by tissue explant method and identified byα-SM-actin immunofluorescence.In transwell co-culture system, the confluent EPCs located in the upper chamber and SMCs were seeded on the lower cham-ber.The experiments were divided into passage 3 SMCs group (P3), passage 4 SMCs group (P4), passage 4 SMCs co-culture with EPCs derived from young rats group (P4YE) and passage 4 SMCs co-culture with EPCs derived from aged rats group (P4AE).The protein expression ofα-SM-actin and osteopontin was detected by Western blotting.[3H]-TdR incor-poration assay was used to determine the proliferation.SMC migration was analyzed by scratch wound healing assay.RE-SULTS:Compared with P3 group,α-SM-actin expression in P4 group significantly decreased and osteopontin protein ex-pression obviously increased, whereas no significant change was found in P4YE group.Compared with P4 group, confluent EPCs derived from young and aged rats both markedly increased α-SM-actin and decreased osteopontin expression in P4 SMCs.Compared with aged rat-derived EPCs, young rat-derived EPCs were more effectively to induce a delayed SMC phe-notype transition (from contractile phenotype to a synthetic phenotype), and to inhibit SMC proliferation and migration. CONCLUSION:Co-culture of confluent EPC induces a delayed vascular SMC phenotype transition and inhibits SMCs pro-liferation and migration.Young rat derived EPCs are more effective to induce a delayed vascular SMC phenotype transition and has stronger inhibitory effects on SMCs proliferation and migration compared with that derived from aged rats.

OBJECTIVE: To sum up the diagnosis and treatment experience of the cervical vertigo after operation of middle ear. METHOD: The clinical data on 4 patients with cervical vertigo after operation of middle ear were analyzed retrospectively. RESULT: Four patients had vertigo closely related to rotation of the head and neck after general anesthesia sober,and had swelling and pain of the neck- occipital and lateral neck. Neck rotation induced test of four cases were positive. Four cases treated with oral difenidol tablets and intravenous Salvia and energy mixture, and the vertigo was cured during 5-7 days. CONCLUSION The key of the diagnosis for the cervical vertigo is pain of the neck and vertigo closely related with rotation of the head and neck. The cause of the cervical vertigo after operation of middle ear is excessive deviation of the head position during operation. Anti-vertigo and vasodilators treatment for the cervical vertigo after operation of middle ear are effective and the prognosis is good. Identification with vertigo caused by the damage of the labyrinthine has important clinical significance.
Adult ; Aged ; Cervical Vertebrae ; Ear, Middle ; surgery ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications ; etiology ; Retrospective Studies ; Vertigo ; diagnosis ; etiology ; therapy

OBJECTIVE: To sum up the diagnosis and treatment experience of the nasal-cardiac reflex initiated by postoperative nasal packing. METHOD: The clinical data of 3 cases with nasal-cardiac reflex initiated by postoperative nasal packing were analyzed retrospectively. RESULT: In the period of postoperative nasal packing, 3 patients had abruptly drops in heart rate and blood pressure associated with symptoms of autonomic dysfunction such as flustered, chest tightness, tachypnea, body sweating et al. There are no positive signs of pathological significance in the cardiovascular and respiratory system. The reflex had spontaneously to be offset with oxygen, comfort touch therapy, pull out the stuffing, no other special treatment for all cases. CONCLUSION The key of the diagnosis for nasal-cardiac reflex is a drop in mean arterial blood pressure (MABP) and the heart rate (HR) more than 20% above the baseline values. The cause of nasal-cardiac reflex initiated by postoperative nasal packing is long-term mechanical pressure on the nasal mucosa and mental factors. Comfort touch therapy and pull out the nasal packing material is effective method to terminate the reflex and the prognosis is good. Correct understanding of the characteristics of the reflex and preventing the occurrence of its adverse consequences have important clinical significance.
Adolescent ; Adult ; Blood Pressure ; Female ; Heart Rate ; Humans ; Male ; Nasal Cavity ; surgery ; Postoperative Period ; Reflex, Abnormal ; Retrospective Studies ; Tachypnea ; etiology ; Trigeminal Nerve ; physiopathology ; Young Adult