Objective To review the advancement of heat shock protein 70(HSP70) vaccine in alimentary canal cancer.Methods Related articles were reviewed.Results HSP70 can integrate with tumor special antigen to form HSP70 polypeptide compound.To activate the special and nonspecial immune response of body,HSP70 can participate in the process of tumor immunity as a "molecular partner".Conclusion HSP70 has shown alluring perspective in the precaution and treatment of alimentary canal cancer.

Based on casting and solvent evaporation method, the degradable PLA/PVA blend film was prepared with polylactic acid (PLA) and polyvinyl alcohol (PVA) as raw material. The moisture absorbability, water absorbability and degradability of the polylactic acid/polyvinyl alcohol (PLA/PVA) blend film were studied; also the degradation mechanism of blend film was investigated. The results showed that the moisture absorption and water absorption of blend film decreased as the concentration of PLA increased. The degradation process of blend film in the normal saline is conducted by stepwise. At the forepart, the degradation of PLA played an important role, while PVA was the main degradation substance later. The solvent acidity could catalyze the degradation of PLA, and degradation of PLA was always turning from noncrystalline region to crystalline region. PVA had abilities to accelerate the degradation of PLA by increasing the hydrophilicity of the blend film and by breaking the crystallinity of PLA. Therefore, the hydrophilicity and degradability of PLA/PVA blend film can be controlled in a certain range by adjusting the proportion of PLA and PVA.
Biocompatible Materials ; chemistry ; Biodegradation, Environmental ; Hydrophobic and Hydrophilic Interactions ; Lactic Acid ; chemistry ; Polyesters ; chemistry ; Polymers ; chemistry ; Polyvinyl Alcohol ; chemistry ; Water ; chemistry

Objective:To study the clinical efficacy of nanocrystalline needles combined with 5% minoxidil tincture in the treatment of androgenetic alopecia of male.Methods:A total of 60 patients with androgenetic alopecia were randomly divided into treatment group and control group, with 30 patients in each group. The control group was treated with 5% minoxidil tincture 2 times a day. On the basis of the control group, the treatment group was treated with nanocrystalline needles combined with 5% minoxidil tincture for 10 minutes 2 times a week. The clinical effects of different treatments were compared after six months.Results:There was a significant difference in overall response rate between the treatment group and the control group (80.00% vs. 53.30%, P<0.05). The improvement of the each clinical features of image by dermoscopy in patients with hair loss disease included more than 20% of hair diameter diminish, vellus hair increased, partly acomia and yellow dot sign had a significant difference between the treatment group and the control group ( P<0.05). Conclusion:Nanocrystalline needles combined with 5% minoxidil tincture has a good clinical effect in the treatment of androgenetic alopecia.

Objective:To investigate the risk factors on androgenetic alopecia (AGA) of primary healthcare staffs.Methods:Primary healthcare staffs were investigated by a questionnaire.Results:A total of 934 healthcare staffs (550 males and 384 females) were surveyed, of which 238 cases were diagnosed as AGA. 68.8% of AGA patients had poor mental health self-assessment; 52.94% of AGA patients had a family history; the prevalence in the people who usually had the night shift was 26.03%, which was higher than that in the people who had no night shift.Conclusions:The prevalence of AGA in healthcare staffs is higher than the national average, which might be related to working pressure, mental status, night shifts, genetic and alcohol drinking.