2.Prospect for research on deregulation of cell proliferation and apoptosis in human gliomas.
Chinese Journal of Pathology 2005;34(9):547-549
Apoptosis
;
Brain Neoplasms
;
genetics
;
pathology
;
Cell Proliferation
;
Genes, Retinoblastoma
;
genetics
;
Genes, erbB-1
;
genetics
;
Genes, p53
;
genetics
;
Glioma
;
genetics
;
pathology
;
Humans
;
Inhibitor of Growth Protein 1
;
Intracellular Signaling Peptides and Proteins
;
genetics
;
Mutation
;
Nuclear Proteins
;
genetics
;
Tumor Suppressor Proteins
;
genetics
6.Safety of high-dose atorvast atin in Chinese patients:a Meta-analysisLI Xuan, CHEN
Ming ZHANG ; Xuan LI ; Hong CHEN ; Chunlai SHI ; Le YU
Chinese Journal of Interventional Cardiology 2016;24(2):88-95
Objective To systematically evaluate the safety of high dose atorvastatin (80 mg daily) in Chinese patients. Methods Randomized controlled trials (RCTs) investigating 80 mg/ d atorvastatin vs. low-dose atorvastatin or placebo or blank were electionically retrieved in date bases of EMbase, PubMed, the Cochrane Library, WanFang, CNKI and WeiPu. Meta-analysis was performed using RevMan 5. 2 and Stata 11. 0 software. Results A total of 20 RCTs involving 2282 cases were included. The results of meta-analysis showed no significant differences betweent the 80 mg/ d atorvastatin group and the control group in the incidence of gastrointestinal adverse events (RR 1. 53, 95% CI 0. 85-2. 76, P = 0. 16), hepatic adverse events (RR 1. 53, 95% CI 0. 99 - 2. 36, P = 0. 05), muscular adverse events (RR 1. 51, 95% CI 0. 92 -2. 49, P = 0. 10), serious hepatic injuries ( RR 2. 33,95% CI 0. 88 - 6. 20, P = 0. 09) and serious muscular myopathies (RR 1. 40, 95% CI 0. 46 - 4. 30, P = 0. 56). Subgroup analysis by type of cotrast media used and durations of taking 80 mg/ d atorvastatin showed there were higher risks of gastrointestinal adverse events in the 80 mg/ d group when compared to blank control ( RR 4. 22, 95% CI 1. 11 - 16. 04, P = 0. 03). Conclusions The current evidence shows that 80 mg / d atorvastatin may be relatively safe in terms of adverse events in gastrointestinal tract, liver and muscular system, and relatively has risk in causing severe liver injuries and myopathies. With limited quantity and quality from the RCTs available, more high quality RCTs are needed to verify the above conclusion.
7.Investigation on cancer related fatigues in oral cancer patients
Miaomiao YU ; Ming WANG ; Lixin SHI ; Xiaotong ZHANG
Modern Clinical Nursing 2013;(10):13-15
Objective To investigate the cancer-related fatigues in oral cancer patients.Methods One hundred oral cancer patients were involved in the survey with self-designed general information questionnaire,revised Piper fatigue correction scale(RPFS).Results Seventy six cases(76.00%)had different degree of fatigue.The total score of RPFS was(5.51+1.23)points. In the descending order of scores,the dimensions were body fatigue,emotional fatigue,behavioral fatigue and cognitive fatigue. Conclusions Oral cancer patients have cancer-related fatigue commonly,with body fatigue the most intense and emotional fatigue at a higher level.Therefore,medical staff should ensure patients intake of enough nutrients in order to reduce the body fatigue and meanwhile should instruct patients to handle their bad moods correctly so as to relieve their metal fatigue.
8.Clinical significance of detecting the expressions of cell phenotypes CD_8 and CD_(28) of peripheral blood lymphocytes in patients with colorectai cancer
Ming YU ; Jixian CHEN ; Zhengchao SHI ; Lingyun LIU ; Weili WU
Chinese Journal of Postgraduates of Medicine 2009;32(35):10-12
Objective To investigate the expressions of cell phenotypes CD_8 and CD_(28) of peripheral blood lymphocytes in patients with colorectal cancer. Method CD_8 and CD_(28) of cell phenotypes were measured by flow cytometry in 50 patients with colorectal cancer (cancer group) and 30 nontumorous patients (control group). Results The expression of CD_8 in cancer group was significantly higher than that in control group [(32.24±8.38)% vs (22.18±7.55)%](P < 0.01). CD_(28) and CD_8~+/CD_(28)~+ were much lower than those in control group [(52.03±10.94)% vs (60.60±7.98)%,12.18±4.28 vs 16.38±4.94](P<0.01). CD_8~+/CD_(28)~+ in Dukes D stage patients were significantly lower than that in Dukes B stage patients (P<0.05). CD_(28) and CD_8~+/CD_(28)~+ in lymph node metastasis patients were much lower than those in lymph node negative patients (P < 0.01). CD_(28) and CD_8~+/CD_(28)~+ in serosa involved patients were lower than those in no serosa involved patients (P < 0.01). Conclusions The expressions of cell phenotypes CD_8 and CD_(28) of peripheral blood lymphocytes in patients with colorectal cancer are closely related to biological characteristics of the tumor. The assays of cell phenotypes CD_8 and CD_(28) might be useful for evaluating the immunal statement and prognosis of patients with colorectal cancer.
10.Cardiac troponin I is increased after interventional closure of congenital heart diseases in children.
Yu-ming QIN ; Da-wei WANG ; Shi-wei YANG
Chinese Journal of Pediatrics 2005;43(12):935-936
Child
;
Child, Preschool
;
Female
;
Heart Defects, Congenital
;
metabolism
;
Humans
;
Male
;
Troponin I
;
metabolism