At the moment of its WTO accession, China also enters the stage of mass higher education. Mass higher education is an objective inevitability of the economic and social development. China's mass higher education lays a firm foundation for China to join the WTO and the WTO entry in turn brings considerable opportunities to it. It is expected that the WTO entry will promote the process of mass higher education of China.

OBJECTIVETo observe the effect of Oxymatrine on left cardiac function and ventricular remodeling in rabbits after acute myocardial infarction.

METHODSLigation of the left anterior descending artery was adopted to establish acute myocardial infarction model, forty eight rabbits were randomized into the sham operation group, model group and Oxymatrine group. Eight models were successfully established in each group. the sham operation group and model group were given conventional feed. Oxymatrine were gavage administration 0.5 ml/100 g, once a day, lasted for 4 weeks. Respectively in postoperative week, and three weeks, to observe the Oxymatrine on cardiac output (CO), left ventricular end systolic pressure (LVESP), left ventricular end-diastolic pressure (LVEDP), left indoor pressure change rate peak (dp/dtmax)), and left ventricular cavity internal diameter (D), ventricular weight index (VWI), ventricular weight (VW).

RESULTSLeft ventricular anterior wall was from red to deep purple, electrocardiogram showed II guide ST-segment camber up ≥ 0.25 mv. Postoperative week in Oxymatrine group compared with model group, LVESP increased significantly (P < 0.01), LVEDP decreased obviously (P < 0.01); After three weeks in Oxymatrine group compared with model group, VW, VWI decreased (P < 0.05), D significantly reduced (P < 0.01); LVESP increased significantly (P < 0.01), LVEDP decreased obviously (P <0.01); dp/dt(max), CO increased (P < 0.05).

CONCLUSIONAfter acute myocardial infarction in rabbit Oxymatrine can improve the left ventricular reconstruction parameters, increase cardiac output, and improve cardiac function.

Alkaloids ; pharmacology ; Animals ; Cardiac Output ; Heart ; drug effects ; Myocardial Infarction ; pathology ; Quinolizines ; pharmacology ; Rabbits ; Ventricular Remodeling ; drug effects

Objective To investigate the correlation of serum advanced glycation end products (AGEs) and the expression of receptor for AGE (RAGE) with mental disorders in senile people. Methods All the subjects aged 65～67 years were divided into 4 groups: healthy control (31 cases), Alzheimer's disease (AD) (36 eases), vascular dementia (VD) (20 cases) and mental disorder (MD) (28 cases). Fluorospectrophotometry was carried out to measure the AGEs levels in serum samples, and reverse transcription polymerase chain reaction (RT-PCR) was used to determine the mRNA levels of RAGE in white blood cells. Results AGEs levels were 477. 1±36.2, 512. 6±33.2 and 415.2±32.5 AU/ml in AD, VD and MD group, respectively, which were higher than that in healthy control group (357.4±28. 2) AU/ml (F=3.77,P<0. 05). The mRNA levels of RAGE(RAGE/b- actin) were found to be 1.12±0.34, 1.27±0.41 and 1.18±0.42 in AD, VD and MD group, respectively, which were also significantly higher than that in healthy control group(0. 92±0. 37, F= 4. 07,P<0. 01). However, no significant differences were found in RAGE mRNA levels among the three groups of AD,VD and MD (F=0. 979,P>0. 05). The mRNA levels of RAGE in WBCs were found to be positively correlated with the serum AGEs levels (r=0. 442, P<0. 01). Conclusions Compared with patients in healthy control group, the serum AGEs levels and RAGE mRNA levels are significantly increased in patients with AD, VD and MD. The interaction between AGEs and RAGE may be involved in the pathogenesis of mental disorders in senile people.

Humans ; Nasal Cavity ; injuries ; Paranasal Sinuses ; Pharynx ; injuries ; Wounds, Penetrating ; diagnosis ; therapy

[Objective]To evaluate the efficacy of nerve transfer for reconstructing the sensory function of the sole.[Method](1)Select saphenous nerve as donor nerve for the patients with the sensory loss beneath ankle level:dissect and cut off the saphenous nerve at the medialposterior aspect at upper-middle 1/3 of the leg and divide the gastrocnemius to expose the tibial nerve at the medialposterior aspect of the tibia, cut off partly nerve fibre of the tibial nerve and then end-to-end anastomose to the proximal end of the saphenous nerve. (2) Select sural nerve as donor nerve for the patients with sensory loss of sole only:dissect and cut off the sural nerve at the posterior aspect of the lateral malleolus, expose the tibial nerve at the posterior aspect of the medial malleolus and then cut off partly nerve fibre of the tibial nerve. The sural nerve was comdicted from the subcutaneous tunel at the anterior aspect of the Achilles's tendon to the posterior aspect of the medial malleolus and end-to-end anastomose to the partial nerve fibre of the tibial nerve. [Result]All the 9 cases were followed up from 1.5 to 2 years(mean 2 l months). The SCV(sensory conduction velocity) of the tibial nerve was ranged from 36.1 to 41.2 m/s, mean 38.3 m/s and the amplitude of wave (peak-to-peak amplitude) was a range from 7 to 15.3?V, mean 11.2 ?V by orthodromic electrophysiologic techniques. All 9 cases regained the sense of pain and touch of the sole.Three cases restored their sense of two point discrimination. All the patients expressed their satisfaction with their ability of walk and no muscles atrophy of the foot. The sensory loss in donor region was oberserved only lateral part of the foot beneath the lateral malleolus (sural nerve as donor nerve) and a small part of the anterior aspect of the ankle(saphenous nerve as donor nerve).[Conclusion]Nerve transfer can reconstruct the sensory function of the sole effectively.

[Objective]To evaluate the clinical outcome of the Ribbed anatomic cementless prosthesis.[Method]A total of 1436 hips in 956 patients undergone THR with Ribbed anatomic cementless prosthesis were reviewed.Between March 1997 and September 2005,1 249 hips in 832 patients were available for clinical and radiological follow-up.The mean follow-up period was 6.7 years with a minimum of 2 and a maximum of 10.5 years.The patients were evaluated with Harris Hip Score and radiographic analysis.[Result]The mean Harris Hip Score increased from 34.7 preoperatively to 91.5 postoperatively.Excellent and good functional improvement was seen in 96.3% of the operated patients.There was neither periprosthetic osteolysis nor evidence of loosening on follow-up radiographs.[Conclusion]Ribbed anatomic cementless prosthesis is found to be performing well with good clinical and radiological result.

BACKGROUND: Wound healing is a complex biological process regulated temporally and spatially by many repair factors. Studies have showed the predominant expression of cytokines in wound healing process, which is a kind of molecular vital reaction, and may be a new reference index in wound age estimation. But the precise relation of the expressions of cytokines and distribution to wound age is not clear.OBJECTIVE: To probe into the relation of the expressions of cytokines and distribution to wound age in the healing process of the mouse skin wounds.DESIGN: A randomized controlled confirmation study based on the experimental animalsSETTING: Department of Pathology of the First Military University of Chinese PLA, which is a key laboratory of molecule oncology of Chinese PLA.MATERIALS: The study was completed in the Key Laboratory of Molecule Oncdogy of Chinese PLA from July to September in 2003. Sixty-five Kunming mice of either gender, weighing 25 - 28 g, were involved.INTERVENTIONS: The mice were randomly divided into the experimental and the control group. The mice in the experimental group were divided into 12 subgroups according to the different times of trauma. The mice were killed at the following time intervals: 15 minutes, 30 minutes, 1 hour, 3 hours, 6hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week or 2 weeks after wound and the wounded skin was excised( n = 5 each). As a control, 5mice without wounding were examined.MAIN OUTCOME MEASURES: The amount and distribution of staining positive inflammation and repair cells in skin wound tissues.RESULTS: Persistent positive expression of vascular endothelial growth factor(VEGF) was seen in the epidermal cells and sebaceous gland cells. The expressions of transforming growth factor β1(TGF-β1) and basic fibroblast growth factor (bFGF) in the epidermal cells were increased at 3 hours after incision and lasted till 12 hours and 48 hours respectively. There was a similar distribution in the positive amount of inflammation and repair cells among VEGF, TGF-β1 and bFGF. Six hours after injury, some of neutrophils showed positive reactions. After 12 hours, macrophages and fibroblasts were mainly positive cells. The number of the positive cells was increased with wound age,and the peak occurred at 96 hours. There were still some positive macrophages and fibroblasts at week 1 and week 2 after the incision.CONCLUSION: There was a time-related expression of TGF-β1 and bFGF in the epidermal cells in mouse skin wounds. The amount and distribution of inflammation and repair cells that express VEGF, TGF-β1 and bFGF were changed in a time-related manner in the healing process of mouse skin wounds.

13.1mmol/L were treated by 2 weeks short-term intensive insulin treatment. FBS, Fasting blood insulin(FINS), glycosylated hemoglobin A1c (HbA1c), 2 hours postprandial blood sugar(PBS 2), Homa ? and Homa IR were measured and compared between pre-treatment and post-treatment. Results After 2 weeks short-term intensive insulin treatment, the excellent control of FBS, PBS 2 in 23 out of 27 patients were achieved respectively in (5.6?2.3)days and (8.5?3.5)days. Homa ? significantly increased, and HbA1c and Homa IR decreased comared with pre-treatment. Conclusions The excellent glycemia control and improvement of ?-cell function can be induced by short-term intensive insulin treatment in newly diagnosed type 2 diabetic patients with severe hyperglycemia.

Cerebrovascular reserve is an important parameter for evaluating cerebrovascular disease,and it has great clinical significance.There are a number of determination methods for cerebrovascular reserve,such as position emission tomography(PET),single photon emission computed tomography(SPECT),Xenon-133 inhalation technique,Xenon CT,perfusion CT, magnetic resonance imaging(MRI),transcranial Doppler(TCD),transcranial harmonic perfusion imaging(HPI),near infrared spectroscopy(NIR),and Laser Doppler vibrometry(LDV), however,there have been no unified criteria up to now.The provocation test that makes cerebral blood flow increase includes CO_2 inhalation test,breath holding test,and acetazolamide test,etc. The article focuses the discussion on the advantages and disadvantages of the above determination methods.