Philosophy has exerted greatly influences on both western medicine and Chinese medicine,both medicines have quite distinctive and interesting recognitions on illness and human being which reflect their own cosmology and its evolutionary progress.A renown scholar ZHU Xi in the Song dynasty of China has reached the peak of neo-Confucianism and elaborated a lot of theories on Chinese cosmology by summarizing scientific achievements at that time;while Immanuel Kant has done very similar to the western world of cosmology.However,their theories make obvious different.As far as the evolution of humankind is concerned,Karl Popper has contributed his distinguished idea that the brain is the center for evolution.To this point,the theory of Chinese medicine,regarding the human-brain as the Ni Wan,ocean of the marrow.Furthermore,the system that the Ren Meridian and the Du Meridian corresponding to human upright vertebrae column in traditional Chinese medicine,makes an in-depth sense,too.

AIM: To establish a specific method for identifying Bailing Capsule(Synnematum sinense,Yin et shen sp.now).METHODS: Using fermented cordyceps powder(C_S-C-Q80),adenosine and uridine as reference standards,a HPLC fingerprint at 260 nm has been established for identification of Bailing Capsule,using Alltima C_(18)(250 mm?4.6 mm,5 ?m) column and acetonitrile-0.04 mol/L KH_2PO_4 in gradient elution as a mobile phase.The flow rate was 0.8 ml/min. RESULTS: The relative standard deviations of stability,precision and reproducibility was less than 3% respectively.The relative standard deviation of relative retention time was less than 5% compared with other HPLC apparatuses and different colunms. CONCLUSION: The method established in this paper has the exclusivity and can be used to identify the Bailing Capsule.

Animals ; Apoptosis ; Carcinoma, Hepatocellular ; pathology ; virology ; Cell Line, Tumor ; Cell Proliferation ; Hepatitis B virus ; Hepatocytes ; pathology ; virology ; Humans ; Liver Neoplasms ; pathology ; virology ; Trans-Activators ; genetics ; metabolism ; physiology

Animals ; Apoptosis ; Cell Cycle ; Cell Cycle Proteins ; genetics ; metabolism ; physiology ; DNA Repair ; Homeodomain Proteins ; genetics ; metabolism ; physiology ; Humans ; Inhibitor of Growth Protein 1 ; Intracellular Signaling Peptides and Proteins ; genetics ; metabolism ; physiology ; Neoplasm Metastasis ; Neoplasms ; metabolism ; pathology ; Neovascularization, Pathologic ; pathology ; Nuclear Proteins ; genetics ; metabolism ; physiology ; Prognosis ; Receptors, Cytoplasmic and Nuclear ; genetics ; metabolism ; physiology ; Signal Transduction ; Transcription Factors ; genetics ; metabolism ; physiology ; Tumor Suppressor Protein p53 ; metabolism ; Tumor Suppressor Proteins ; chemistry ; genetics ; metabolism ; physiology

Autopsy ; legislation & jurisprudence ; standards ; Cause of Death ; Dissent and Disputes ; Forensic Pathology ; Humans ; Malpractice ; legislation & jurisprudence ; Medical Errors ; legislation & jurisprudence

Cardiovascular System ; metabolism ; Humans ; Risk Assessment

Objective To observe and compare the recent objective response rate and adverse reaction of docetaxe and irinotecan combined with cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Sixty-five patients with advanced NSCLC were randomly divided into goup A consisted of 33 patients received docetaxe plus capecitabine and group B consisted of 32 patients received irinotecan plus capecitabine with a 21-day regimen. Two or more cycles of chemotherapy were completed in each group. Results Sixty-five patients were assessable for efficacy and toxicities. In group A, 2 patients achieved complete response, 13 patients partial response, overall response rate was 45.45 % and the median progression-free survival (PFS) was 10.1 months. In group B, 2 patients achieved complete response, 12 patients partial response, overall response rate was 43.75 %, and the median PFS was 10.2 months. The efficacy and PFS were not significantly different between the two groups(P ＞0.05). The most common adverse reactions were myelosuppression and gastrointestinal response in the two groups. The main adverse reactions is anemia in group A and diarrhoea in group B. Patients in group A experienced more anemia. On the contrary,the rate in group B was more increased. No chemotherapy-related death was observed. Conclusion The effects of docetaxe combined with cisplatin and irinotecan combined with cisplatin in the treatment of advanced NSCLC are comparable and equivalent, and the adverse reactions can be tolerated.

Objective To investigate the distribution and drug resistance state of Pseudomonas aeruginosa, so as to offer reasonable experimental data for clinical therapy. Methods A statistic analy- sis for the specimen souree, distribution of infected departments and drug resistance state to 441 iso- lates was conducted in a retrospective way. Results Among 441 strains, 357 (80. 95%) were isolated from sputum species. The department with the highest isolating rate was ICU (26.5%), followed by department of respiratory disease (20. 63 %), department of neurosurgery (19.05 %) and department of geriatrics (17. 01%). The most sensitive antibiotic was Meropenem, which total drug resistance rate was 13. 61%; the most insensitive antibiotic was ampicillin-sulbactam, which total drug resistance rate was 91.38%. The drug resistance rate of P. Aeruginosa was increasing year by year. Conclusion Clinical isolates of P. Aeruginosa mostly come from sputum samples and ICU, and they are highly and multidrug resistant to various antibiotics.

Human peripheral blood lymphocytes and sheep red blood cells(SRBC)were incubated together in Hanks solution containing Ca~(2+) and Mg~(2+) ion, causing SRBC destruction and release of hemoglobin, 500%hemolysis value was found to 6.1921?0.06. The destruction of SRBC by lymphocytes was inhibited by trypsinase, its 50% hemolysis value became 0.0348?0.03 (P

Objective To establish and verify the animal model of sclerotic skin induced by bleomycin(Blm).Methods To establish a mouse model for scleroderma in C3H/He mice by repeated local injection of100?L of Blm(200?g/mL)everyday for3weeks.Then,the specimens of skin,lung and serum were examined.Results After3week local Blm injections,an intense dermal sclerosis was shown in C3H/He mice.Compared with the control skin,increased dermal thickness and increased collagen histo-chemical index were found(P