Philosophy has exerted greatly influences on both western medicine and Chinese medicine,both medicines have quite distinctive and interesting recognitions on illness and human being which reflect their own cosmology and its evolutionary progress.A renown scholar ZHU Xi in the Song dynasty of China has reached the peak of neo-Confucianism and elaborated a lot of theories on Chinese cosmology by summarizing scientific achievements at that time;while Immanuel Kant has done very similar to the western world of cosmology.However,their theories make obvious different.As far as the evolution of humankind is concerned,Karl Popper has contributed his distinguished idea that the brain is the center for evolution.To this point,the theory of Chinese medicine,regarding the human-brain as the Ni Wan,ocean of the marrow.Furthermore,the system that the Ren Meridian and the Du Meridian corresponding to human upright vertebrae column in traditional Chinese medicine,makes an in-depth sense,too.

AIM: To establish a specific method for identifying Bailing Capsule(Synnematum sinense,Yin et shen sp.now).METHODS: Using fermented cordyceps powder(C_S-C-Q80),adenosine and uridine as reference standards,a HPLC fingerprint at 260 nm has been established for identification of Bailing Capsule,using Alltima C_(18)(250 mm?4.6 mm,5 ?m) column and acetonitrile-0.04 mol/L KH_2PO_4 in gradient elution as a mobile phase.The flow rate was 0.8 ml/min. RESULTS: The relative standard deviations of stability,precision and reproducibility was less than 3% respectively.The relative standard deviation of relative retention time was less than 5% compared with other HPLC apparatuses and different colunms. CONCLUSION: The method established in this paper has the exclusivity and can be used to identify the Bailing Capsule.

Animals ; Apoptosis ; Carcinoma, Hepatocellular ; pathology ; virology ; Cell Line, Tumor ; Cell Proliferation ; Hepatitis B virus ; Hepatocytes ; pathology ; virology ; Humans ; Liver Neoplasms ; pathology ; virology ; Trans-Activators ; genetics ; metabolism ; physiology

Animals ; Apoptosis ; Cell Cycle ; Cell Cycle Proteins ; genetics ; metabolism ; physiology ; DNA Repair ; Homeodomain Proteins ; genetics ; metabolism ; physiology ; Humans ; Inhibitor of Growth Protein 1 ; Intracellular Signaling Peptides and Proteins ; genetics ; metabolism ; physiology ; Neoplasm Metastasis ; Neoplasms ; metabolism ; pathology ; Neovascularization, Pathologic ; pathology ; Nuclear Proteins ; genetics ; metabolism ; physiology ; Prognosis ; Receptors, Cytoplasmic and Nuclear ; genetics ; metabolism ; physiology ; Signal Transduction ; Transcription Factors ; genetics ; metabolism ; physiology ; Tumor Suppressor Protein p53 ; metabolism ; Tumor Suppressor Proteins ; chemistry ; genetics ; metabolism ; physiology

Autopsy ; legislation & jurisprudence ; standards ; Cause of Death ; Dissent and Disputes ; Forensic Pathology ; Humans ; Malpractice ; legislation & jurisprudence ; Medical Errors ; legislation & jurisprudence

Angiomyolipoma ; pathology ; Bile Duct Neoplasms ; pathology ; virology ; Bile Ducts, Intrahepatic ; Carcinoma, Hepatocellular ; pathology ; virology ; Carcinosarcoma ; pathology ; Cholangiocarcinoma ; pathology ; virology ; Hepatitis B ; Hepatitis C ; Humans ; Liver Neoplasms ; pathology ; virology ; Pathology, Clinical ; trends

AlM:To observe and compare the influence of different incision cataract phacoemulsification on comprehensive state in patients. METHODS: Sixty patients with cataract who were treated with phacoemulsification in our hospital from November 2012 to May 2014 were selected as research object, and they were divided into group A ( corneal incision group) 30 cases and group B ( corneoscleral rim incision group) 30 cases according to the disease state. Epithelial and incision repair time, tear break-up time, tear secretion, corneal staining score and tear related indexes before and after the treatment of two groups were respectively analyzed and compared. RESULTS: The epithelial and incision repair time constitution of group B were better than those of group A, the incision repair time, tear break - up time, tear secretion, corneal staining score and tear related indexes at 1,7, 14 and 28d after the treatment were all significantly better than those of group A too, there were all significant differences (all P<0. 05).CONCLUSlON: The application value of corneoscleral rim incision in the patients with cataract phacoemulsification is relatively higher,and bad influence of this method for the patients is smaller, the postoperative recovery of comprehensive state are faster.

AIM: To investigate the effect and mechanism of Mingjing decoction combining with argon laser on the levels of plasma vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy(DR).
METHODS:The 66 patients(118 eyes)with DR at Ⅲ ~ Ⅴstage were randomly divided into two groups (treatment group and control group). The control group (33 patients with 56 eyes ) was treated with argon laser, and the treatment group (33 patients with 62 eyes) was treated with mingjing decoction combining with argon laser, and a blank group(30 eyes) was set up. The levels of plasma VEGF were detected by enzyme linked immunosorbent assay (ELISA). The results of best corrected visual acuity and fundus fluorescein angiography(FFA) were analyzed, as well as detected glycosylated hemoglobin ( HbA1c), blood coagulation function and the function of liver and kidney.
RESULTS: Patients with DR had significantly risen plasma VEGF before treatment when compared with blank control group ( P < 0. 05 ). After 3mo of combined treatment, the levels of plasma VEGF significantly reduced and HbA1c decreased in patients treated with mingjing decoction and argon laser, there were statistically significant difference compared to control group ( P < 0. 05 ). In the treatment group, the best corrected visual acuity and FFA were significantly improved in patients treated with mingjing decoction combining with argon laser compared to patients treated with argon laser alone after 3mo of combined treatment. CONCLUSION: Mingjing decoction combining with argon laser for DR can effectively reduce the level of plasma VEGF, stabilize blood sugar levels, improve the function of retina, and delay DR progresses.

Epilepsy is a chronic disorder of brain, whose pathogenesis is closely related to ion channel, heredity, neurotransmit-ters, cytokine, immunity and neuroglia cells, etc. Traditional Chinese medicines ( TCMs) have made achievements in the treatment of epilepsy in recent years. The paper systematically reviewed the research situations of TCM and the combination of TCM and western medicines for the prevention and therapy of epilepsy in recent ten years. The results indicated that TCMs showed notable curative effect on epilepsy, and the pathogenesis was closely related to neuroprotection, neurotransmitters, ion channel, and relevant gene regulation, etc. The combination of TCM and western medicines can enhance the efficacy and reduce the toxicity in the treatment of epilepsy.

Objective To investigate the distribution and drug resistance state of Pseudomonas aeruginosa, so as to offer reasonable experimental data for clinical therapy. Methods A statistic analy- sis for the specimen souree, distribution of infected departments and drug resistance state to 441 iso- lates was conducted in a retrospective way. Results Among 441 strains, 357 (80. 95%) were isolated from sputum species. The department with the highest isolating rate was ICU (26.5%), followed by department of respiratory disease (20. 63 %), department of neurosurgery (19.05 %) and department of geriatrics (17. 01%). The most sensitive antibiotic was Meropenem, which total drug resistance rate was 13. 61%; the most insensitive antibiotic was ampicillin-sulbactam, which total drug resistance rate was 91.38%. The drug resistance rate of P. Aeruginosa was increasing year by year. Conclusion Clinical isolates of P. Aeruginosa mostly come from sputum samples and ICU, and they are highly and multidrug resistant to various antibiotics.