3.Evaluation on Clinical Effects of Pumpkin Polysaccharide Granules for Diabetes Ⅱ
Xuemin XIONG ; Jue CAO ; Yang SHI ; Ming KANG ;
Chinese Traditional Patent Medicine 1992;0(07):-
Objective:To evaluate the clinical effects of Pumpkin Polysaccharide Granules for diabetes Ⅱ.Methods:The clinical effects were evaluated on the governing principle of clinical investigation of diabetes treatment with new Chinese medicinal. In experiment the clinical effects of Pumpkin Polysaccharide Granules (as a treatment group) were compared with that of Xiaoke pill (as a control group).Results:The total effective rate of treatment group was 87.13%, 10 cases of then marked effect, 16 cases effect, 4 cases no improvement. The total effective rate of control group was 70.00%. The treatment group was superior to the control group ( P
4.Percutaneous Closure of Patent Ductus Arteriosus on Plasma N-Terminal Brain Natriuretic Peptide Level and Left Ventricular Function
shi-wei, YANG ; yu-ming, QIN ; li-ming, CAO ; da-wei, WANG
Journal of Applied Clinical Pediatrics 2006;0(13):-
Objective To evaluate the effect of percutaneous closure of patent ductus arteriosus(PDA)on left ventricular size and function by measuring plasma N-terminal brain natriuretic peptide(NT-proBNP)level and using two-dimensional echocardiography.Methods According to the modified Ross score,55 children with PDA were divided into 3 groups,no congestive heart failure(CHF)group(31 cases),mild CHF group(14 cases)and moderate-severe CHF group(10 cases).Fifteen age-matched and weight-matched normal children were used as controls.Plasma NT-proBNP was measured using enzyme-linked immunosorbent assay(ELISA).All patients had complete echocardiographic study,including measurement of left ventricular end diastolic volume index(LVEDVI),left ventricular end systolic volume index(LVESVI),and left ventricular ejection fraction(LVEF),and left ventricular fractional shortening(LVFS).The correlation between plasma NT-proBNP level and echocardiographic cardiac functional indexes was determined.Results 1.Before operation LVEDVI and LVESVI in PDA patients were obviously higher than those in normal controls(Pa0.05).3.Three months after operation plasma NT-proBNP level,LVEDVI and LVESVI were significantly decreased(P
5.Effects of Plasmid Fibroblast Growth Factor-2 Magnetic Chitosan Gelatin Microspheres on Proliferation and Differentiation of Mesenchymal Stem Cells.
Xingpo DING ; Ming LI ; Yujiang CAO ; Qiong YANG ; Tongchuan HE ; Cong LUO ; Haibing LI ; Yang BI
Journal of Biomedical Engineering 2015;32(5):1083-1089
The purpose of this study is to investigate the effect of superparamagnetic chitosan FGF-2 gelatin microspheres (SPCFGM) on the proliferation and differentiation of mouse mesenchymal stem cells. The superparamagnetic iron oxide chitosan nanoparticles (SPIOCNs) were synthesized by means of chemical co-precipitation, combined with FGF-2. Then The SPCFGM and superparamagnetic chitosan gelatin microspheres (SPCGM) were prepared by means of crosslinking-emulsion. The properties of SPCFGM and SPIONs were measured by laser diffraction particle size analyser and transmisson electron microscopy. The SPCFGM were measured for drug loading capacity, encapsulation efficiency and release pharmaceutical properties in vitro. The C3H10 cells were grouped according to the different ingredients being added to the culture medium: SPCFGM group, SPCGM group and DMEM as control group. Cell apoptosis was analyzed by DAPI staining. The protein expression level of FGF-2 was determined by Western blot. The proliferation activity and cell cycle phase of C3H10 were examined by CCK8 and flow cytometry. The results demonstrated that both of the SPIOCNs and SPCFGM were exhibited structure of spherical crystallization with a diameter of (25 ± 9) nm and (140 ± 12) μm, respectively. There were no apoptosis cells in the three group cells. Both the protein expression level of FGF-2 and cell proliferation activity increased significantly in the SPCFGM group cells (P < 0.05). The SPCFGM is successfully constructed and it can controlled-release FGF-2, remained the biological activity of FGF-2, which can promote proliferation activity of C3H10 cells, and are non-toxic to the cell.
Animals
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Cell Differentiation
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Cell Line
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Cell Proliferation
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Chitosan
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Fibroblast Growth Factor 2
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pharmacology
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Gelatin
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Magnetite Nanoparticles
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Mesenchymal Stromal Cells
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drug effects
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Mice
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Microspheres
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Plasmids
6.Comparison of effectiveness between intra-arterial and intra-venous neoadjuvant chemotherapy in stage Ⅰb2-Ⅱ b cervical carcinoma
Dongyan CAO ; Jiaxin YANG ; Keng SHEN ; Yang XIANG ; Lingya PAN ; Jinghe LANG ; Ming WU ; Huifang HUANG
Chinese Journal of Obstetrics and Gynecology 2008;43(12):888-891
Objective To compare the effect between intra-arterial and intra-venous neoadjuvant chemotherapy(NACT)in stage Ⅰb2-Ⅱ b cervical carcinoma.Methods A retrospective analysis Was done on 52 cases of intra-venous NACT and 95 eases of intm-arterial NACT for stage Ⅰ b2-Ⅱ b cervical carcinoma treatad in Peking Union Medical College Hospital from 1999.ResulIs The response rate of intraveHous NACT and intra-arterial NACT was 88%(46/52)and 79%(75/95).and the operative rate after NACT Was 81%(42/52)and 72%(68/95)respectively(P>0.05).There were no significant differences in surgery time,blood loss and pest-operative morbidity between these two groups.Pathological parametrial positive rate after NACT in arterial group(6%)Was significantly lower than that of venous group (50%,P>0.05).The venous group had very similar recurrence rates(13%vs 17%)and death rates (9%VS 12%)when compared with the arterial group(P>0.05).Conclusions The intra-arterial and intra-venous NACT for stage Ⅰ b2-Ⅱb cervical carcinoma show similar response rate.operative rate and surgical difficulties.Arterial NACT shows a better effect on parametrial infiltration.
7.To provide safer and better emergency service for elderly patients
Jin FAN ; Ming YIN ; Lining XU ; Yang SONG ; Ruihua CAO ; Xue YANG
Chinese Journal of Geriatrics 2016;35(12):1263-1266
8.Oncologic and fertility outcomes of young patients with early stage of cervical cancer treated by vaginal radical trachelectomy
Dongyan CAO ; Jiaxin YANG ; Yang XIANG ; Ming WU ; Lingya PAN ; Huifang HUANG ; Jinghe LANG ; Keng SHEN
Chinese Journal of Obstetrics and Gynecology 2014;(4):249-253
Objective To evaluate the prognosis and fertility outcomes of patients with early stage of cervical cancer treated by vaginal radical trachelectomy ( VRT ) in combination with laparoscopic pelvic lymphadenectomy.Methods The surgical data , disease recurrences and fertility outcomes were analyzed retrospectively for 51 patients who received VRT in Peking Union Medical College Hospital from Dec.2003 to Nov.2013.Results Forty-eight patients succeeded in preserving fertility.The median age was 29 years.International Federation of Gynecology and Obstetrics ( FIGO ) stage: 5 cases Ⅰa1 with lymph vascular space invasion (LVSI),4 cases Ⅰa2 and 39 cases in stage Ⅰb1.Tumor size: 20 cases with no visible lesion, 20 cases with tumor size ≤2 cm, 8 cases with tumor size >2 cm.Histological type:42 cases with squamous carcinoma , 6 cases with adenocarcinoma or adeno-squamous carcinoma.The mean excised cervical length and parametrial width was ( 2.6 ±0.6 ) cm and ( 1.9 ±0.5 ) cm, respectively.Six recurrences ( 12%) were observed after following up for a mean duration of ( 35 ±21 ) months.The recurrent rate in patients with tumor size >2 cm was 3/8, which was significantly higher than that of the
patients with tumor size ≤2 cm (8%, 3/40;P<0.01).Of the 35 patients who desired to conceive after the surgery, 13 women had 17 pregnancies and the pregnant rate was 37% (13/35).Nine women obtained 10 healthy live birth babies.The fertility rate was 26%( 9/35 ).Conclusions VRT in combination with laparoscopic pelvic lymphadenectomy could preserve the fertility of patients with early stage of cervical cancer with acceptable oncologic and fertility outcomes.Tumor size ≤2 cm should be emphasized as the indication of VRT in considering of the higher recurrent rate in patients with tumor size >2 cm.
9.Comparison of the application of different version of diagnostic criteria for occupational noise-induced deafness
ZHANG Xiao xiao YANG Ai chu LIANG Xiao yang XIAO Ming hui CAO Dan yan
China Occupational Medicine 2022;49(06):626-630
Objective - ( )
To explore the influence on the diagnosis of occupational noise induced deafness ONID using three
, Methods
versions of diagnostic criteria in 2002 2007 and 2014. A total of 1 766 workers who asked for ONID diagnosis
were selected as the research subjects using judgment sampling method. The results of pure tone audiometry were collected.
GBZ 49-2002Diagnostic Criteria of Occupational Noise-inducedHearing Loss(
The ONID was diagnosed using hereinafter referred to as
GBZ 49-2002),GBZ 49-2007Diagnostic Criteria of Occupational Noise-induced Deafness( GBZ 49-2007)
hereinafter referred to as
GBZ 49-2014 Diagnostic of Occupational Noise-induced Deafness( GBZ 49-2014),
and hereinafter referred to as and the
Results - - , -
diagnostic results were compared. Compared with GBZ 49 2002 and GBZ 49 2007 diagnosis with GBZ 49 2014 had
( vs , vs , P ), ( vs ,
a higher rate of ONID 57.9% 66.0% 44.8% 66.0% both <0.01 and had a higher rate of mild ONID 47.3% 54.6%
vs , P ) - -
36.0% 54.6% both <0.01 . The diagnostic rate for ONID using GBZ 492014 was higher than those using GBZ 49 2002 and
- ( P )Conclusion -
GBZ 49 2007 in each age groups all <0.01 . GBZ 49 2014 improved the diagnostic rate of ONID compared
- -
with GBZ 49 2002 and GBZ 49 2007. The reason is related to the inclusion of 4 000 Hz hearing threshold with a weight of 0.1
-
as the diagnostic hearing threshold and the use of a new age and gender correction method in GBZ 49 2014.
10.Study tetrandrine defer extraceller matrix mechanism
Xing-Gang DONG ; Ming LU ; Hai-Chun YANG ; He-Xing CAO ; Dong-Sheng ZHU ; Chuan-Ji YE ; Ming-Hua XU ;
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(03):-
Aim The effect of tetrandrine on TGF-?1 mRNA expression in glomerulosclerosis rat was observed. Methods The rats were randomly divided into four groups, such as the normal control group (sham operative rat), glomerulosclerosis model group,tetrandrine group and amlodipine group. The expression of TGF-?1 mRNA was analyzed by Northern blot hybridization. Results The expressions of TGF-?1 mRNA in two treating groups were much lower than untreated model group. There were no difference between these two treating groups. Conclusion Tetrandrine can decrease the expression of TGF-?1 mRNA in glomerulosclerosis rat induced by unilateral renctomy plus adriamycin.