ObjectiveTo compare the effect of psychological treatment only and psychological combined with fluoxetine treatment in reducing symptom of depression, anxiety and in improving of cognitive and daily living abilities for post-stroke depression patients.MethodsAll patients with post-stroke enrolled in hospital between 1996 and 2001 and were evaluated by using of the Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS), Scale of Elderly Cognitive Function (SECF), and Ability of Daily Living (ADL). SDS score was equal or greater than 50 points (SDS≥50) selected as subjects for this study. A total of 115 patients were randomized divided into psychological with fluoxetine treatment group (Group A,54 patients) and psychological treatment group (Group B,61 patients). There is no significant difference between two groups in age, education, and left or right side of hemiplegics. Statistical analysis was performed by using Chi test and t test to compare the 2 groups at day 0 (baseline) and after 2 months.ResultsThe level of depression and anxiety reduced significantly in both Group A and Group B from baseline to end of treatment (P<0.001). Both groups had significant improvement in daily living ability (P<0.001).There was no significant improvement in cognitive ability (P>0.5). There was no significant differences on SDS, SAS, SECF, and ADL scores from baseline to end of treatment (P>0.5).Conclusions There were similar effect of psychological with fluoxetine treatment and of psychological treatment only on post-stroke depression.

ObjectiveTo analyze the relationship among depression and anxiety and other possible factors in post-stroke patients.Methods510 hospitalized stroke patients from 1997 to 2004 were evaluated with the Scale of Elderly Cognitive Function (SECF), Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), and Activities of Daily Living (ADL) in 7 days after admission and re-examined after two months.ResultsThe depression group exhibited the longer course of disease, a high ratio of hemiplegia in left side, lower ADL scores and higher SAS scores at time of admission. There were significant differences between depression and non-depression group. However, there was no significant difference between the depression and cognitive function. There were also significant differences between anxiety group and non-anxiety group. Patients with anxiety displayed symptoms of low ADL scores and higher SDS scores at time of admission, and ADL scores increased after treatment. Additionally, the course of disease was longer and reduction of anxiety level was lower. The levels of depression and anxiety significantly reduced in depression group and anxiety group when compared to the control group.ConclusionEarly rehabilitation can help to reduce depression level. Modest anxiety may help stroke patients to improve their ADL. There is close relationship between depression and anxiety.

Objective To analyze the injury mechanism and distribution of the motor vehicle engine shake shaft caused injuries (MVESSCI) in North Henan province. Methods A follow up was done on 520 patients with the motor vehicle engine shaft injuries treated in our hospital from January 1998 to May 2002. The epidemiological features were analyzed concerning gender, age, injury time and injury sites. Results There were 300 males and 220 females (age range of 9-53 years, mean 31 years) with ratio 1.36 ∶1 of male to female. The MVESSCI were dominated by Colles fractures and distal fractures of ulna and radius, accounting for 73.8% (384/520). The traffic accidents occurred most in May, June, September and October, which accounted for 85.0% (442/520). Conclusions (1) The vehicle engine shake shaft causes the injuries mainly at the distal part of the right forearm, mainly the Colles fracture and the distal fractures of ulna and radius. (2) The injury is mainly due to improper operation in busy farming seasons. (3) The countermeasures to reduce wounds and injuries are to pay much more attention to prevention, strengthen the safety awareness of individuals, improve the structures of motor vehicles and avoid improper manipulation of the vehicles by children.

During the past 30 years, Alzheimer's disease (AD) drug R&D aiming at a variety of potential targets has undergone tremendous setback although a large amount of resources have been invested by pharmaceutical companies, governments, academic institutions and venture capitals globally. There is no doubt that uneasy early diagnosis, unsatisfying therapeutic strategies and genetic polymorphism of AD patients bringing variety of responses to the drugs contribute to the failure of AD drug therapy, but the most important reason might be that people have insufficient understanding of the very complex diseases including AD. Continuing to make efforts in the previous way to find AD drugs might not be a good way. Development of systems biomedicine opens an avenue to understand the disease networks and pursue multi-target drugs R&D based on systems pharmacology theory; neural stem cell transplantation, and neurogenesis affected by small molecules might bring new hope for AD therapy; discovery of new biomarkers of AD will help the study of the pathogenesis and diagnosis of the disease and finally the discovery of new types of AD drugs.
Alzheimer Disease ; drug therapy ; Biomedical Research ; trends ; Humans

Adult ; Aged ; Digoxin ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Heart Failure ; drug therapy ; Humans ; Male ; Middle Aged ; Phytotherapy

Humans ; Purpura, Thrombocytopenic, Idiopathic

Molecular transport controls the efficiency of complex biological network systems such as cellular signaling system and cascade biomedical reaction. However, device fabrication for molecular sensing is often restricted by a low transport effciency and complicated processing. Here, we report a molecular threading dependent transport system using three-dimensional (3D) paper origami enabling the directional transport of biomolecules. We demonstrate that framework nucleic acid based interface engineering allows orthogonal molecular recognition and enzymatic reaction with programmed order on site. We thus develop a single-step electrochemical DNA sensor for quantitative analysis with 1 picomolar sensitivity within 60 min. Our sensor can discriminate a mismatched target at the level of a single base mismatch. Our study shows a great potential toward the development of a biomimetic molecular transport system for point-of-care and precision diagnosis.

Rat acute pancreatitis was induced by the injection of dog bile into a closed duodenal loop. It was found that lung index and extravascular lung water were significantly increased 6 h after the induction of pancreatitis. Histological examination revealed pulmonary congestion, edema, and atelecta-sis. There was a strong correlation between pancreatic and pulmonary injury. Increased serum and lung lipid peroxide (LPO) was parallel to the degree of pancreatic and lung injury. The results indicate that increase in LPO may be a result of pancreatitis-induced lung injury.

OBJECTIVE:To provide a reference for further strengthening the supervision and administration of the management and use of Papaver somniferum. METHODS:The general information,clinical application and toxic reactions of P. somniferum were briefly described by reference to relevant literatures and on the basis of the actual work. According to current laws and regula-tions,the existing problems about the clinical application and management of P. somniferum were revealed,and relevant counter-measures and suggestions were put forward. RESULTS&CONCLUSIONS:Both toxic and addictive,P. somniferum is the only tra-ditional Chinese herbal medicine covered by narcotic drug management. It is mainly used in clinical practice to relieve cough,diar-rhea and pain,etc. Although relevant laws and regulations have provided the specific requirements for the production,purchase, use and research & development of P. somniferum,slack enforcement of the laws and regulations,irrational use and abuse still ex-ist. It is suggested that State Food and Drug Administration and health administrative departments should constantly improve rele-vant law and regulation system and detailed regulations,strengthen supervision and administration,and strictly enforce relevant laws and regulations at the units engaged in the production,management and use of P. somniferum. Meanwhile,competent authori-ties should strengthen publicity and training.

OBJECTIVE:To explore the characteristics and rules of adverse drug reactions (ADR) of ciprofloxacin,and pro-vide reference for clinical rational drug use. METHODS:Usingciprofloxacinandadverse drug reactionsas key words,the lit-eratures reported in Wanfang database in 1998-2015 were retrieved,the gender,age,route of administration,the original disease, ADR occurrence time,ADR involving organs/systems,the main clinical manifestations,allergies,prognosis and outcome were sta-tistically analyzed. RESULTS:Totally 181 valid literatures were retrieved,involving 213 patients. Male was more than female (57.28% vs. 42.72%);it mainly occurred in the first day(130 cases,61.03%);intravenous injection(179 cases,84.04%)was the main administration route;the main ADR involving organs/systems were systemic damage(71 cases,33.33%)and nervous sys-tem damage(50 cases,23.47%);the main clinical manifestations were anaphylactic shock(65 cases,30.52%),severe cases can cause death (3 cases,1.41%). CONCLUSIONS:The clinic should strictly master the ciprofloxacin indications,use rationally, give close observation to the course of medication,alert the incidence of ADR.